Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ap3d1mh-2J mocha 2 Jackson MGI:1856084 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the degree of dilution is less severe than in mocha homozygotes
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• the degree of dilution is less severe than in mocha homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mocha 2 Jackson homozygotes do not display the hypersynchronized EEG or head tilt seen in mocha homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• hearing is normal, even up to ages 1.5 years, with ABR readings normal at frequencies of 4,000, 10,000, and 20,000
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• at least as severe as that seen in mocha homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• The S1 response, but not the S2 response, is greater than in controls and the resulting auditory gating has a trend toward enhanced gating relative to controls but it does not reach statistical significance in this study
• this phenotype is less severe in the mh-2J homozygotes than in mh homozygotes
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• spike discharge episodes of .25-1 mV amplitude and approximately 0.5-2 seconds duration observed for 4 of 7 homozygotes, less frequently than in mocha homozygotes
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• spike discharge episodes of .25-1 mV amplitude and approximately 0.5-2 seconds duration observed for 4 of 7 homozygotes, less frequently than in mocha homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Ap3d1mh-2J/Ap3d1mh-2J coat color dilution is attenuated in Ap3d1mh-2J/Ap3d1mh-2J Nxf1Mvb1/Nxf1Mvb1 mice
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• normalization of pigmentation relative to Ap3d1mh-2J single homozygotes
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• normalization of pigmentation relative to Ap3d1mh-2J single homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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