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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MitfMi-b
microphthalmia brownish
MGI:1856086
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		MitfMi-b/MitfMi-b involves: 101/Rl * C3H/Rl MGI:3526549
ht2
 		MitfMi-b/Mitf+ involves: 101/Rl * C3H/Rl MGI:3526551
ht3
 		MitfMi-b/MitfMi-wh involves: 101/Rl * C3H/Rl MGI:4410316
ht4
 		MitfMi-b/MitfMi-Or involves: 101/Rl * C3H/Rl MGI:4410317


Genotype
MGI:3526549
hm1
Allelic
Composition		 MitfMi-b/MitfMi-b
Genetic
Background		 involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-b mutation (2 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal Harderian gland pigmentation ( J:37067 )
• pigment granules are absent
absent coat pigmentation ( J:37067 )
• the coat is completely white
abnormal choroid pigmentation ( J:37067 )
• no pigmentation is found in the choroid
abnormal retina pigment epithelium morphology ( J:37067 )
• pigment granules are sparse

endocrine/exocrine glands
abnormal Harderian gland pigmentation ( J:37067 )
• pigment granules are absent

vision/eye
abnormal choroid pigmentation ( J:37067 )
• no pigmentation is found in the choroid
abnormal ciliary process morphology ( J:37067 )
• fewer than normal ciliary processes
abnormal retina morphology ( J:37067 )
• ciliary bodies have fewer processes than wild-type or heterozygous mice
• pigment greatly reduced in ciliary body and inner layer of iris
• there is a single pigmented epithelial layer rather than normal stratified layer
abnormal retina pigment epithelium morphology ( J:37067 )
• pigment granules are sparse
increased susceptibility to age-related retinal degeneration ( J:37067 )
• reduction in photoreceptor outer segment length begins as early as 19 days of age; inner and outer nuclear layers are normal
• by 3 months of age inner and outer nuclear layers as well as the ganglion layers are reduced significantly

integument
absent coat pigmentation ( J:37067 )
• the coat is completely white




Genotype
MGI:3526551
ht2
Allelic
Composition		 MitfMi-b/Mitf+
Genetic
Background		 involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-b mutation (2 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
decreased ear pigmentation ( J:37067 )
• ears are pale
abnormal Harderian gland pigmentation ( J:37067 )
• pigment granules are absent
diluted coat color ( J:37067 )
• diluted pigmentation with brownish cast
abnormal eye pigmentation ( J:37067 )
• extreme reduction in choroid layer
abnormal choroid pigmentation ( J:37067 )
• only a few foci of pigment are found

endocrine/exocrine glands
abnormal Harderian gland pigmentation ( J:37067 )
• pigment granules are absent

hearing/vestibular/ear
decreased ear pigmentation ( J:37067 )
• ears are pale

limbs/digits/tail

vision/eye
abnormal eye pigmentation ( J:37067 )
• extreme reduction in choroid layer
abnormal choroid pigmentation ( J:37067 )
• only a few foci of pigment are found

craniofacial
decreased ear pigmentation ( J:37067 )
• ears are pale

integument
decreased ear pigmentation ( J:37067 )
• ears are pale
diluted coat color ( J:37067 )
• diluted pigmentation with brownish cast

growth/size/body
decreased ear pigmentation ( J:37067 )
• ears are pale




Genotype
MGI:4410316
ht3
Allelic
Composition		 MitfMi-b/MitfMi-wh
Genetic
Background		 involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-b mutation (2 available); any Mitf mutation (74 available)
MitfMi-wh mutation (8 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:15061 )
• agouti mice are light cream with white spots
decreased eye pigmentation ( J:15061 )
• eyes appear ruby

vision/eye
decreased eye pigmentation ( J:15061 )
• eyes appear ruby

integument
abnormal coat/hair pigmentation ( J:15061 )
• agouti mice are light cream with white spots




Genotype
MGI:4410317
ht4
Allelic
Composition		 MitfMi-b/MitfMi-Or
Genetic
Background		 involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-b mutation (2 available); any Mitf mutation (74 available)
MitfMi-Or mutation (2 available); any Mitf mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
absent coat pigmentation ( J:15061 )
• mice are white, indistinguishable from mice homozygous for Mitf

vision/eye

integument
absent coat pigmentation ( J:15061 )
• mice are white, indistinguishable from mice homozygous for Mitf




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory