All Phenotypes Mitf<Mi-wh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mitf^Mi-wh
white
MGI:1856088

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mitf^Mi-wh/Mitf^Mi-wh	B6.Cg-Mitf^Mi-wh	MGI:3762342
hm2	Mitf^Mi-wh/Mitf^Mi-wh	involves: C57BL * C57BL/6J * DBA	MGI:4455019
hm3	Mitf^Mi-wh/Mitf^Mi-wh	involves: C57BL * DBA	MGI:3044413
ht4	Mitf^Mi-wh/Mitf⁺	involves: C57BL * DBA	MGI:3044414
ht5	Mitf^Mi-wh/Mitf^mi-sp	B6.Cg-Mitf^Mi-wh/Mitf^mi-sp/J	MGI:3821718
ht6	Mitf^Mi-b/Mitf^Mi-wh	involves: 101/Rl * C3H/Rl	MGI:4410316
ht7	Mitf^tm4.1Arnh/Mitf^Mi-wh	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316634
ht8	Mitf^tm5.1Arnh/Mitf^Mi-wh	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316609
ht9	Mitf^tm6.1Arnh/Mitf^Mi-wh	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316621
ht10	Mitf^tm7Arnh/Mitf^Mi-wh	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316601
ht11	Mitf^tm4Arnh/Mitf^Mi-wh	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316596
ht12	Mitf^tm7.1Arnh/Mitf^Mi-wh	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316616
ht13	Mitf^tm5Arnh/Mitf^Mi-wh	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316597
ht14	Mitf^tm6Arnh/Mitf^Mi-wh	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316599
ht15	Mitf^Mi-wh/Mitf^mi-x	involves: NZB/Mac	MGI:2663064
cx16	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:3044424
cx17	Mitf^Mi-wh/Mitf^Mi-wh Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:3044429
cx18	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:4455023
cx19	Mitf^Mi-wh/Mitf^Mi-wh Tfeb^tm1Est/Tfeb⁺	involves: 129S1/Sv * C57BL * C57BL/6J * DBA	MGI:4455024
cx20	Mitf^Mi-wh/Mitf⁺ Myo5a^d/Myo5a^d	involves: C57BL * DBA	MGI:3762341

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh
Genetic Background	B6.Cg-Mitf^Mi-wh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal retina pigment epithelium morphology ( J:5046 )

• pigment granules are absent at E11

• at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region

• after E12 in some area the cells are columnar rather than cuboidal

• at all stages the number of mitoses is increased compared to control pigment layers

abnormal retina pigmentation ( J:5046 )

• pigment granules are absent from the pigment layer at E11

• after E12, a few pigment granules may be found in the front edge of the pigment layer

• at birth a few pigment granules are present near the iris

vision/eye

abnormal optic cup morphology ( J:5046 )

• slightly reduced in size from E13 onwards

• irregularly formed surrounding less than half of the spherical lens

abnormal optic fissure closure ( J:5046 )

• at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close

• in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure

abnormal optic stalk morphology ( J:5046 )

• slight increase in diameter at E11

• shorter and somewhat greater in diameter at E11.5 and E12

microphthalmia ( J:5046 )

• slightly smaller at birth

abnormal posterior eye segment morphology ( J:5046 )

• the lens fills the space normally occupied by the vitreous body

abnormal retina pigment epithelium morphology ( J:5046 )

• pigment granules are absent at E11

• at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region

• after E12 in some area the cells are columnar rather than cuboidal

• at all stages the number of mitoses is increased compared to control pigment layers

abnormal retina pigmentation ( J:5046 )

• pigment granules are absent from the pigment layer at E11

• after E12, a few pigment granules may be found in the front edge of the pigment layer

• at birth a few pigment granules are present near the iris

abnormal retina neuronal layer morphology ( J:5046 )

• at birth, the layers are less clearly defined

abnormal optic choroid morphology ( J:5046 )

• at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup

• in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure

skeleton

skeleton phenotype ( J:5046 )

N	• unlike Mitf^Mi homozygotes no skeletal abnormalities are seen

homeostasis/metabolism

decreased bleeding time ( J:7327 )

• bleed time of only 1 minute after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh
Genetic Background	involves: C57BL * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

decreased eye pigmentation ( J:89821 )

• eyes are slightly pigmented

skeleton

skeleton phenotype ( J:89821 )

N	• normal bone development and mice do not develop osteopetrosis

vision/eye

decreased eye pigmentation ( J:89821 )

• eyes are slightly pigmented

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh
Genetic Background	involves: C57BL * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mitf^Mi-wh/+ and Mitf^Mi-wh/Mitf^Mi-wh and control

pigmentation

absent coat pigmentation ( J:13058 , J:125080 )

• coat color is indistinguishable from that of Tyr^c homozygotes (J:13058)

• the coat is entirely lacking pigment (J:125080)

ocular albinism ( J:13058 )

• eyes are pink and pigmentless

decreased eye pigmentation ( J:125080 )

• little or no pigment in the iris

vision/eye

ocular albinism ( J:13058 )

• eyes are pink and pigmentless

decreased eye pigmentation ( J:125080 )

• little or no pigment in the iris

microphthalmia ( J:13058 , J:125080 )

• eye size appears reduced compared to f Tyr^c homozygotes (J:13058)

• the eyes are only mildly reduced in size (J:125080)

growth/size/body

decreased body size ( J:13058 )

• reduced body size compared to f Tyr^c homozygotes

reproductive system

reduced fertility ( J:125080 )

decreased litter size ( J:13058 )

• litter size is reduced in homozygous female to homozygous male crosses

hearing/vestibular/ear

abnormal cochlea morphology ( J:125080 )

• no section of the cochlear duct was ever found to be normal

abnormal cochlear hair cell morphology ( J:125080 )

abnormal stria vascularis morphology ( J:125080 )

• abnormal in its entirety

abnormal vestibular saccule morphology ( J:125080 )

• the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

nervous system

abnormal cochlear hair cell morphology ( J:125080 )

integument

absent coat pigmentation ( J:13058 , J:125080 )

• coat color is indistinguishable from that of Tyr^c homozygotes (J:13058)

• the coat is entirely lacking pigment (J:125080)

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
ocular albinism with sensorineural deafness	DOID:0090100		J:13058
Tietz syndrome	DOID:0090002	OMIM:103500	J:13058
Waardenburg syndrome type 2A	DOID:0110950	OMIM:193510	J:13058

Allelic Composition	Mitf^Mi-wh/Mitf⁺
Genetic Background	involves: C57BL * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mitf^Mi-wh/+

pigmentation

diluted coat color ( J:13058 , J:125080 )

• coat color is gray and somewhat lighter than that of Myo5a^d homozygotes (J:13058)

• coat color darkens slightly with age (J:13058)

white spotting ( J:125080 )

• small spots may occur on the back, but spotting is not found on the head

abnormal foot pigmentation ( J:13058 )

• reduced foot pigmentation

decreased tail pigmentation ( J:13058 )

• reduced tail pigmentation

abnormal iris pigmentation ( J:125080 )

• moderate dilution of the iris pigmentation

decreased eye pigmentation ( J:13058 )

• eyes are a very dark ruby color

limbs/digits/tail

decreased tail pigmentation ( J:13058 )

• reduced tail pigmentation

vision/eye

abnormal iris pigmentation ( J:125080 )

• moderate dilution of the iris pigmentation

decreased eye pigmentation ( J:13058 )

• eyes are a very dark ruby color

integument

diluted coat color ( J:13058 , J:125080 )

• coat color is gray and somewhat lighter than that of Myo5a^d homozygotes (J:13058)

• coat color darkens slightly with age (J:13058)

white spotting ( J:125080 )

• small spots may occur on the back, but spotting is not found on the head

abnormal foot pigmentation ( J:13058 )

• reduced foot pigmentation

decreased tail pigmentation ( J:13058 )

• reduced tail pigmentation

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
ocular albinism with sensorineural deafness	DOID:0090100		J:13058
Tietz syndrome	DOID:0090002	OMIM:103500	J:13058
Waardenburg syndrome type 2A	DOID:0110950	OMIM:193510	J:13058

Allelic Composition	Mitf^Mi-wh/Mitf^mi-sp
Genetic Background	B6.Cg-Mitf^Mi-wh/Mitf^mi-sp/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-sp mutation (10 available); any Mitf mutation (74 available)
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:12946 , J:35685 )

• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum (J:12946)

• at the first moult the hairs that had initially been pale yellow become sooty in color (J:12946)

yellow coat color ( J:12946 )

abnormal hair shaft melanin granule morphology ( J:12946 )

• medullary granules vary greatly in size and shape and are less dense than wild-type

diluted coat color ( J:12946 )

white spotting ( J:12946 )

abnormal foot pigmentation ( J:12946 )

• the tail, feet, and ears are largely unpigmented although the eyes have pigment

hypopigmentation ( J:12946 )

decreased ear pigmentation ( J:12946 )

decreased tail pigmentation ( J:12946 )

craniofacial

decreased ear pigmentation ( J:12946 )

hearing/vestibular/ear

decreased ear pigmentation ( J:12946 )

limbs/digits/tail

decreased tail pigmentation ( J:12946 )

integument

decreased ear pigmentation ( J:12946 )

abnormal coat/hair pigmentation ( J:12946 , J:35685 )

• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum (J:12946)

• at the first moult the hairs that had initially been pale yellow become sooty in color (J:12946)

yellow coat color ( J:12946 )

abnormal hair shaft melanin granule morphology ( J:12946 )

• medullary granules vary greatly in size and shape and are less dense than wild-type

diluted coat color ( J:12946 )

white spotting ( J:12946 )

abnormal foot pigmentation ( J:12946 )

• the tail, feet, and ears are largely unpigmented although the eyes have pigment

decreased tail pigmentation ( J:12946 )

growth/size/body

decreased ear pigmentation ( J:12946 )

Allelic Composition	Mitf^Mi-b/Mitf^Mi-wh
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-b mutation (2 available); any Mitf mutation (74 available)
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:15061 )

• agouti mice are light cream with white spots

variable body spotting ( J:15061 )

decreased eye pigmentation ( J:15061 )

• eyes appear ruby

vision/eye

decreased eye pigmentation ( J:15061 )

• eyes appear ruby

integument

abnormal coat/hair pigmentation ( J:15061 )

• agouti mice are light cream with white spots

variable body spotting ( J:15061 )

Allelic Composition	Mitf^tm4.1Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm4.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:182722 )

• gray, darkening somewhat with age

white spotting ( J:182722 )

• small spots may occur on the body, but spotting is not found on the head

integument

diluted coat color ( J:182722 )

• gray, darkening somewhat with age

white spotting ( J:182722 )

• small spots may occur on the body, but spotting is not found on the head

Allelic Composition	Mitf^tm5.1Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm5.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

darkened coat color ( J:182722 )

• considerably darkened compared to heterozygous Mitf^Mi-wh/Mitf⁺ mice

belly spot ( J:182722 )

pigmentation

darkened coat color ( J:182722 )

• considerably darkened compared to heterozygous Mitf^Mi-wh/Mitf⁺ mice

belly spot ( J:182722 )

Allelic Composition	Mitf^tm6.1Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm6.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

darkened coat color ( J:182722 )

• slightly darker coat color

integument

darkened coat color ( J:182722 )

• slightly darker coat color

Allelic Composition	Mitf^tm7Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm7Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

integument

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

Allelic Composition	Mitf^tm4Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm4Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

integument

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

Allelic Composition	Mitf^tm7.1Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm7.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

darkened coat color ( J:182722 )

• considerably darkened

belly spot ( J:182722 )

integument

darkened coat color ( J:182722 )

• considerably darkened

belly spot ( J:182722 )

Allelic Composition	Mitf^tm5Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm5Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

integument

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

Allelic Composition	Mitf^tm6Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm6Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

integument

diluted coat color ( J:182722 )

• fawn coat color

white spotting ( J:182722 )

Allelic Composition	Mitf^Mi-wh/Mitf^mi-x
Genetic Background	involves: NZB/Mac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^mi-x mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:83501 )

• reduced eye size

abnormal eyelid morphology ( J:83501 )

• eyelid closure is of variable extent

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
ocular albinism with sensorineural deafness	DOID:0090100		J:83501
Tietz syndrome	DOID:0090002	OMIM:103500	J:83501
Waardenburg syndrome type 2A	DOID:0110950	OMIM:193510	J:83501

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:89821 )

• most die at 3-4 weeks of age, although some survive to adulthood

pigmentation

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^Mi-wh/Mi-wh mice

growth/size/body

decreased body weight ( J:89821 )

• smaller and more runted than single homozygotes

skeleton

osteopetrosis ( J:89821 )

• bones show signs of osteopetrosis with intermediate extensions of bony trabeculae; less severe than in homozygous Tcfe3^tm1Est mice with other Mitf mutations

vision/eye

microphthalmia ( J:89821 )

• similar to Mitf^Mi-wh/Mi-wh mice

integument

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^Mi-wh/Mi-wh mice

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

skeleton

skeleton phenotype ( J:89821 )

N	• osteopetrosis is not observed amd bone development appears normal

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

osteopetrosis ( J:89821 )

• mice develop osteopetrosis similar to that observed in double Mitf^Mi-wh and Tcfe3^tm1Est mutants

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfeb^tm1Est/Tfeb⁺
Genetic Background	involves: 129S1/Sv * C57BL * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

skeleton phenotype ( J:89821 )

N	• mutants do not develop osteopetrosis

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^Mi-wh/Mitf⁺ Myo5a^d/Myo5a^d
Genetic Background	involves: C57BL * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Myo5a^d mutation (105 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:13058 )

• coat color is pastel gray or silver

decreased eye pigmentation ( J:13058 )

• eyes are red

vision/eye

decreased eye pigmentation ( J:13058 )

• eyes are red

integument

diluted coat color ( J:13058 )

• coat color is pastel gray or silver

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