Phenotypes associated with this allele

• Allele Symbol: Mitf^mi-di
• Allele Name: microphthalmia defective iris
• Allele ID: MGI:1856090
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mitf^mi-di/Mitf^mi-di	(PT x C3H/HeH)F1	MGI:3522321

Genotype
MGI:3522321

hm1

• Allelic Composition: Mitf^mi-di/Mitf^mi-di
• Genetic Background: (PT x C3H/HeH)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

absent coat pigmentation ( J:8196 )

• coats are white

decreased eye pigmentation ( J:8196 )

• pigment restricted to ring of iris pigment around the pupil

hematopoietic system

abnormal spleen morphology ( J:8196 )

abnormal spleen red pulp morphology ( J:8196 )

• showed broad bands of myeloid tissue not found in background stock

abnormal spleen white pulp morphology ( J:8196 )

abnormal spleen germinal center morphology ( J:8196 )

• Malpighian bodies more abundant than normal, many with germinal centers rarely seen in background stock

immune system

abnormal spleen morphology ( J:8196 )

abnormal spleen red pulp morphology ( J:8196 )

• showed broad bands of myeloid tissue not found in background stock

abnormal spleen white pulp morphology ( J:8196 )

abnormal spleen germinal center morphology ( J:8196 )

• Malpighian bodies more abundant than normal, many with germinal centers rarely seen in background stock

skeleton

osteopetrosis ( J:8196 )

• mildly defective bone resorption in active bone growth areas

vision/eye

abnormal retina photoreceptor morphology ( J:8196 )

abnormal photoreceptor inner segment morphology ( J:8196 )

• inner segments of the photoreceptors are poorly developed

absent photoreceptor outer segment ( J:8196 )

• outer segments are absent

decreased eye pigmentation ( J:8196 )

• pigment restricted to ring of iris pigment around the pupil

abnormal retina development ( J:8196 )

• retinal lamination is highly distorted with rosetting of the outer nuclear layer

• ganglion layer varies in thickness

• inner nuclear layer is abnormally thick; the outer nuclear layer is abnormally thin

• retinal epithelium varies randomly in cell thickness

microphthalmia ( J:8196 )

• 60% normal size

abnormal vitreous body morphology ( J:8196 )

• vitreous body is absent

nervous system

abnormal retina photoreceptor morphology ( J:8196 )

abnormal photoreceptor inner segment morphology ( J:8196 )

• inner segments of the photoreceptors are poorly developed

absent photoreceptor outer segment ( J:8196 )

• outer segments are absent

integument

absent coat pigmentation ( J:8196 )

• coats are white