All Phenotypes Atp7a<Mo-ms> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp7a^Mo-ms
mottled mosaic
MGI:1856100

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Atp7a^Mo-ms/Atp7a⁺	Not Specified	MGI:4940053
ot2	Atp7a^Mo-ms/Y	involves: CBA	MGI:4940052
ot3	Atp7a^Mo-ms/Y	involves: CBA/Kw	MGI:4940054
ot4	Atp7a^Mo-ms/Y	Not Specified	MGI:4940051

Allelic Composition	Atp7a^Mo-ms/Atp7a⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-ms mutation (0 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/ hair morphology ( J:15062 )

• mice exhibit mutant hair arranged in an irregular pattern of transverse bars compared with wild-type mice

• however, coat color is normal

curly vibrissae ( J:15062 )

• postnatally, but straightened in adults

Allelic Composition	Atp7a^Mo-ms/Y
Genetic Background	involves: CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-ms mutation (0 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased kidney copper level ( J:80157 )

renal/urinary system

increased kidney copper level ( J:80157 )

decreased renal glomerulus number ( J:80157 )

decreased kidney weight ( J:80157 )

abnormal renal tubule morphology ( J:80157 )

Allelic Composition	Atp7a^Mo-ms/Y
Genetic Background	involves: CBA/Kw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-ms mutation (0 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:14875 )

• average life span is 16 days

• life span is influenced by genetic background of fostering dam

homeostasis/metabolism

decreased circulating ceruloplasmin level ( J:14875 )

• mice exhibit reduced ceruloplasmin serum levels

abnormal copper homeostasis ( J:14875 )

• mice exhibit poor copper absorption from the intestine compared with wild-type mice

• mice exhibit reduced ceruloplasmin serum levels and low o-diphenol oxidase activity in the eyeball compared with wild-type mice

increased intestine copper level ( J:14875 )

decreased brain copper level ( J:14875 )

• copper levels in the brain are less than in wild-type mice

decreased liver copper level ( J:14875 )

integument

abnormal awl hair morphology ( J:14875 )

abnormal zigzag hair morphology ( J:14875 )

curly vibrissae ( J:14875 )

behavior/neurological

hindlimb paresis ( J:14875 )

• paresis in the hindlimb beginning at day 8

growth/size/body

weight loss ( J:14875 )

• at P8

liver/biliary system

decreased liver copper level ( J:14875 )

nervous system

decreased brain copper level ( J:14875 )

• copper levels in the brain are less than in wild-type mice

digestive/alimentary system

increased intestine copper level ( J:14875 )

Allelic Composition	Atp7a^Mo-ms/Y
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^Mo-ms mutation (0 available); any Atp7a mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:168658 )

ataxia ( J:168658 )

hindlimb paralysis ( J:168658 )

homeostasis/metabolism

abnormal copper level ( J:168658 )

• mice exhibit increased copper levels in the kidney but decreased copper levels in the brain and liver compared with wild-type mice

decreased brain copper level ( J:168658 )

increased kidney copper level ( J:168658 )

decreased liver copper level ( J:168658 )

integument

diluted coat color ( J:15062 )

abnormal vibrissa morphology ( J:15062 )

• mice exhibit abnormal pigmentation and hair structure of the vibrissae compared with wild-type mice

curly vibrissae ( J:15062 )

liver/biliary system

decreased liver copper level ( J:168658 )

mortality/aging

postnatal lethality, complete penetrance ( J:15062 )

• mice die between 2 and 3 weeks of age

nervous system

increased neuron apoptosis ( J:157286 )

• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice

decreased brain copper level ( J:168658 )

pigmentation

diluted coat color ( J:15062 )

cellular

increased neuron apoptosis ( J:157286 )

• arcuate nucleus growth hormone-releasing hormone (GHRH) neurons exhibit morphological changes associated with apoptosis unlike in wild-type mice

renal/urinary system

increased kidney copper level ( J:168658 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Menkes disease		DOID:1838	OMIM:309400	J:168658

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24