Phenotypes associated with this allele

• Allele Symbol: Vsx2^or
• Allele Name: ocular retardation
• Allele ID: MGI:1856111
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsx2^or/Vsx2^or	involves: C57BL/Gr	MGI:4358055
cx2	Fign^fi/Fign^fi Vsx2^or/Vsx2^or	involves: C57BL/Gr	MGI:5637751

Genotype
MGI:4358055

hm1

• Allelic Composition: Vsx2^or/Vsx2^or
• Genetic Background: involves: C57BL/Gr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

lacrimal gland hypertrophy ( J:307 )

• glands located between the eyeball and the orbit are hypertrophied

abnormal optic nerve morphology ( J:307 )

• the nerves start to develop but do not penetrate through the outer pigmented layer

absent optic chiasm ( J:307 )

absent optic nerve ( J:307 )

• absent in the adult

abnormal lens morphology ( J:307 )

• distorted shape and non-crystalline

abnormal eye development ( J:307 )

• eye size and proportions are normal until E11

• eye size decreases after E11 due to failure of the central artery and vein to establish a pathway along the choroid fissure

abnormal optic stalk morphology ( J:307 )

• degenerates and missing in the adult

microphthalmia ( J:307 )

• a reduction in primary blood supply results in severely retarded eye development

• evident at birth

nervous system

abnormal optic nerve morphology ( J:307 )

• the nerves start to develop but do not penetrate through the outer pigmented layer

absent optic chiasm ( J:307 )

absent optic nerve ( J:307 )

• absent in the adult

endocrine/exocrine glands

lacrimal gland hypertrophy ( J:307 )

• glands located between the eyeball and the orbit are hypertrophied

Harderian gland hypertrophy ( J:307 )

• glands located between the eyeball and the orbit are hypertrophied

cellular

abnormal cell cycle checkpoint function ( J:5575 )

• G1 is prolonged in E12 retina anlange

Genotype
MGI:5637751

cx2

• Allelic Composition: Fign^fi/Fign^fi; Vsx2^or/Vsx2^or
• Genetic Background: involves: C57BL/Gr

cellular

abnormal cell cycle checkpoint function ( J:5575 )

• tritium labelling shows that DNA synthesis is stopped in retinal anlage of E12 mutant mice of this doubly homozygous genotype whereas G1 is prolonged in the retina anlage of E12 mutant mice homozygous for individual genotypes