All Phenotypes Vsx2<or-J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vsx2^or-J
ocular retardation Jackson
MGI:1856112

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsx2^or-J/Vsx2^or-J	129S1/Sv	MGI:3765059
hm2	Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv	MGI:5449361
ht3	Vsx2^or-J/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ	MGI:5449362
ht4	Vsx2^or-J/Vsx2^or-2J	involves: 129S1/Sv * NOR2/LtDn	MGI:3799539
cx5	Mitf^Mi/Mitf⁺ Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv * 129X1/SvJ	MGI:5449363
cx6	Vsx2^or-J/Vsx2^or-J Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:3052551
cx7	Vsx2^or-J/Vsx2^or-J Modor3^CASA/Rk/?	involves: 129S1/Sv * CASA/Rk	MGI:3656511
cx8	Vsx2^or-J/Vsx2^or-J Modor2^CASA/Rk/?	involves: 129S1/Sv * CASA/Rk	MGI:3656510
cx9	Vsx2^or-J/Vsx2⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129/Sv * C57BL/6 * FVB/N * SJL	MGI:3052553
cx10	Vsx2^or-J/Vsx2^or-J Modor1^CASA/Rk/?	involves: 129X1/SvJ * CASA/Rk	MGI:3656509

Allelic Composition	Vsx2^or-J/Vsx2^or-J
Genetic Background	129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:5966 )

• at E12.5 there is no evidence of expected ganglion cell differentiation

absent optic nerve ( J:5767 )

• at weaning, mice have a layer of connective tissue in place of the optic nerve

decreased eye pigmentation ( J:5767 )

small lens ( J:5767 )

• lens is reduced in size and fills most of eyecup

abnormal eye development ( J:5767 )

• in comparison to wild-type only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk

abnormal hyaloid artery morphology ( J:5767 )

• hyaloid artery is reduced in homozygotes at E11.5

abnormal lens development ( J:5767 )

• homozygotes exhibit delayed lens formation

abnormal optic cup morphology ( J:5767 )

abnormal optic fissure morphology ( J:5767 )

• by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material

abnormal optic stalk morphology ( J:5767 , J:5966 )

• stalk is reduced in size or absent by E13 (J:5767)

• formation of the optic stalk fissure is delayed and remained abnormal (J:5966)

abnormal retina progenitor cell morphology ( J:5767 )

microphthalmia ( J:5767 )

• small eyes are observed by E12

eyelids fail to open ( J:5767 )

disorganized retina layers ( J:5767 )

• retinal layers are uneven and normal cell layers are missing

nervous system

abnormal retina ganglion cell morphology ( J:5966 )

• at E12.5 there is no evidence of expected ganglion cell differentiation

absent optic nerve ( J:5767 )

• at weaning, mice have a layer of connective tissue in place of the optic nerve

pigmentation

decreased eye pigmentation ( J:5767 )

cellular

abnormal cell death ( J:5966 )

• at E10.5 the retinas of mutant mice show no evidence of cell death compared with retinas of normal mice where zones of cell necrosis are obvious

• at E12.5 necrotic foci in mutant retinas far exceed the number found in wild-type mice

cardiovascular system

abnormal hyaloid artery morphology ( J:5767 )

• hyaloid artery is reduced in homozygotes at E11.5

Allelic Composition	Vsx2^or-J/Vsx2^or-J
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Small eyes in various Vsx2 homozygous mutants

vision/eye

small lens ( J:190452 )

microphthalmia ( J:190452 )

• by E11.5

• becomes progressively more severe with age

abnormal retina morphology ( J:190452 )

abnormal retina pigment epithelium morphology ( J:190452 )

• thickened

abnormal retina pigmentation ( J:190452 )

• ectopic pigmentation of the retina

abnormal retina development ( J:190452 )

• onset of neurogenesis is delayed by 1-2 days in the retina

decreased total retina thickness ( J:190452 )

pigmentation

abnormal retina pigment epithelium morphology ( J:190452 )

• thickened

abnormal retina pigmentation ( J:190452 )

• ectopic pigmentation of the retina

Allelic Composition	Vsx2^or-J/Vsx2^tm1.1Eml
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)
Vsx2^tm1.1Eml mutation (0 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Eye circumference of various Vsx2 mutants

vision/eye

microphthalmia ( J:190452 )

• phenotype is intermediate between mice homozygous for either allele

Allelic Composition	Vsx2^or-J/Vsx2^or-2J
Genetic Background	involves: 129S1/Sv * NOR2/LtDn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-2J mutation (1 available); any Vsx2 mutation (23 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:30714 )

N	• Background Sensitivity: although ocular retardation 2 Jackson homozygotes are infertile, compound heterozygotes of both sexes are fertile

Allelic Composition	Mitf^Mi/Mitf⁺ Vsx2^or-J/Vsx2^or-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi mutation (3 available); any Mitf mutation (74 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The dominant negative Mitf^Mi allele restores retinal development in the Vsx2 mutants

vision/eye

abnormal eye morphology ( J:190452 )

• substantial improvements in eye size, tissue histology and retinal neurogenesis compared to mice homozygous for Vsx2^or-J alone

abnormal eye size ( J:190452 )

• substantial improvements in eye size compared to mice homozygous for Vsx2^or-J alone

Allelic Composition	Vsx2^or-J/Vsx2^or-J Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina rod cell number ( J:91498 )

• only 10 - 25% of cells in dissociated retinal cell counts are rods compared to over 70% in wild-type mice

microphthalmia ( J:91498 )

• at E11.5 eyes are noticeably smaller compared to heterozygous littermates

disorganized retina layers ( J:91498 )

• lamination of the retina is severely reduced or absent

nervous system

decreased retina rod cell number ( J:91498 )

• only 10 - 25% of cells in dissociated retinal cell counts are rods compared to over 70% in wild-type mice

Allelic Composition	Vsx2^or-J/Vsx2^or-J Modor3^CASA/Rk/?
Genetic Background	involves: 129S1/Sv * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Modor3^CASA/Rk mutation (0 available); any Modor3 mutation (0 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye size ( J:109796 )

• increased eye weight

• milder presentation of blindness and microphthalmia phenotype typical of Chx10^or-J mutation

Allelic Composition	Vsx2^or-J/Vsx2^or-J Modor2^CASA/Rk/?
Genetic Background	involves: 129S1/Sv * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Modor2^CASA/Rk mutation (0 available); any Modor2 mutation (0 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye size ( J:109796 )

• increased eye weight

• milder presentation of blindness and microphthalmia phenotype typical of Chx10^or-J mutation

Allelic Composition	Vsx2^or-J/Vsx2⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal Muller cell morphology ( J:91498 )

• more Muller cells are observed in the retina

nervous system

abnormal Muller cell morphology ( J:91498 )

• more Muller cells are observed in the retina

Allelic Composition	Vsx2^or-J/Vsx2^or-J Modor1^CASA/Rk/?
Genetic Background	involves: 129X1/SvJ * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Modor1^CASA/Rk mutation (0 available); any Modor1 mutation (0 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye size ( J:109796 )

• increased eye weight

• milder presentation of blindness and microphthalmia phenotype typical of Chx10^or-J mutation

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