All Phenotypes Vsx2<or-J> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vsx2^or-J
ocular retardation Jackson
MGI:1856112

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsx2^or-J/Vsx2^or-J	129S1/Sv	MGI:3765059
hm2	Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv	MGI:5449361
ht3	Vsx2^or-J/Vsx2^tm1.1Eml	involves: 129S1/Sv * 129X1/SvJ	MGI:5449362
ht4	Vsx2^or-J/Vsx2^or-2J	involves: 129S1/Sv * NOR2/LtDn	MGI:3799539
cx5	Mitf^Mi/Mitf⁺ Vsx2^or-J/Vsx2^or-J	involves: 129S1/Sv * 129X1/SvJ	MGI:5449363
cx6	Vsx2^or-J/Vsx2^or-J Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:3052551
cx7	Vsx2^or-J/Vsx2^or-J Modor3^CASA/Rk/?	involves: 129S1/Sv * CASA/Rk	MGI:3656511
cx8	Vsx2^or-J/Vsx2^or-J Modor2^CASA/Rk/?	involves: 129S1/Sv * CASA/Rk	MGI:3656510
cx9	Vsx2^or-J/Vsx2⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129/Sv * C57BL/6 * FVB/N * SJL	MGI:3052553
cx10	Vsx2^or-J/Vsx2^or-J Modor1^CASA/Rk/?	involves: 129X1/SvJ * CASA/Rk	MGI:3656509

Allelic Composition	Vsx2^or-J/Vsx2^or-J
Genetic Background	129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:5966 )

• at E12.5 there is no evidence of expected ganglion cell differentiation

absent optic nerve ( J:5767 )

• at weaning, mice have a layer of connective tissue in place of the optic nerve

decreased eye pigmentation ( J:5767 )

small lens ( J:5767 )

• lens is reduced in size and fills most of eyecup

abnormal eye development ( J:5767 )

• in comparison to wild-type only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk

abnormal hyaloid artery morphology ( J:5767 )

• hyaloid artery is reduced in homozygotes at E11.5

abnormal lens development ( J:5767 )

• homozygotes exhibit delayed lens formation

abnormal optic cup morphology ( J:5767 )

abnormal optic fissure morphology ( J:5767 )

• by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material

abnormal optic stalk morphology ( J:5767 , J:5966 )

• stalk is reduced in size or absent by E13 (J:5767)

• formation of the optic stalk fissure is delayed and remained abnormal (J:5966)

abnormal retina progenitor cell morphology ( J:5767 )

microphthalmia ( J:5767 )

• small eyes are observed by E12

eyelids fail to open ( J:5767 )

disorganized retina layers ( J:5767 )

• retinal layers are uneven and normal cell layers are missing

nervous system

abnormal retina ganglion cell morphology ( J:5966 )

• at E12.5 there is no evidence of expected ganglion cell differentiation

absent optic nerve ( J:5767 )

• at weaning, mice have a layer of connective tissue in place of the optic nerve

pigmentation

decreased eye pigmentation ( J:5767 )

cellular

abnormal cell death ( J:5966 )

• at E10.5 the retinas of mutant mice show no evidence of cell death compared with retinas of normal mice where zones of cell necrosis are obvious

• at E12.5 necrotic foci in mutant retinas far exceed the number found in wild-type mice

cardiovascular system

abnormal hyaloid artery morphology ( J:5767 )

• hyaloid artery is reduced in homozygotes at E11.5

Allelic Composition	Vsx2^or-J/Vsx2^or-J
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Small eyes in various Vsx2 homozygous mutants

vision/eye

small lens ( J:190452 )

microphthalmia ( J:190452 )

• by E11.5

• becomes progressively more severe with age

abnormal retina morphology ( J:190452 )

abnormal retina pigment epithelium morphology ( J:190452 )

• thickened

abnormal retina pigmentation ( J:190452 )

• ectopic pigmentation of the retina

abnormal retina development ( J:190452 )

• onset of neurogenesis is delayed by 1-2 days in the retina

decreased total retina thickness ( J:190452 )

pigmentation

abnormal retina pigment epithelium morphology ( J:190452 )

• thickened

abnormal retina pigmentation ( J:190452 )

• ectopic pigmentation of the retina

Allelic Composition	Vsx2^or-J/Vsx2^tm1.1Eml
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)
Vsx2^tm1.1Eml mutation (0 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Eye circumference of various Vsx2 mutants

vision/eye

microphthalmia ( J:190452 )

• phenotype is intermediate between mice homozygous for either allele

Allelic Composition	Vsx2^or-J/Vsx2^or-2J
Genetic Background	involves: 129S1/Sv * NOR2/LtDn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx2^or-2J mutation (1 available); any Vsx2 mutation (23 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:30714 )

N	• Background Sensitivity: although ocular retardation 2 Jackson homozygotes are infertile, compound heterozygotes of both sexes are fertile

Allelic Composition	Mitf^Mi/Mitf⁺ Vsx2^or-J/Vsx2^or-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi mutation (3 available); any Mitf mutation (72 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The dominant negative Mitf^Mi allele restores retinal development in the Vsx2 mutants

vision/eye

abnormal eye morphology ( J:190452 )

• substantial improvements in eye size, tissue histology and retinal neurogenesis compared to mice homozygous for Vsx2^or-J alone

abnormal eye size ( J:190452 )

• substantial improvements in eye size compared to mice homozygous for Vsx2^or-J alone

Allelic Composition	Vsx2^or-J/Vsx2^or-J Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina rod cell number ( J:91498 )

• only 10 - 25% of cells in dissociated retinal cell counts are rods compared to over 70% in wild-type mice

microphthalmia ( J:91498 )

• at E11.5 eyes are noticeably smaller compared to heterozygous littermates

disorganized retina layers ( J:91498 )

• lamination of the retina is severely reduced or absent

nervous system

decreased retina rod cell number ( J:91498 )

• only 10 - 25% of cells in dissociated retinal cell counts are rods compared to over 70% in wild-type mice

Allelic Composition	Vsx2^or-J/Vsx2^or-J Modor3^CASA/Rk/?
Genetic Background	involves: 129S1/Sv * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Modor3^CASA/Rk mutation (0 available); any Modor3 mutation (0 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye size ( J:109796 )

• increased eye weight

• milder presentation of blindness and microphthalmia phenotype typical of Chx10^or-J mutation

Allelic Composition	Vsx2^or-J/Vsx2^or-J Modor2^CASA/Rk/?
Genetic Background	involves: 129S1/Sv * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Modor2^CASA/Rk mutation (0 available); any Modor2 mutation (0 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye size ( J:109796 )

• increased eye weight

• milder presentation of blindness and microphthalmia phenotype typical of Chx10^or-J mutation

Allelic Composition	Vsx2^or-J/Vsx2⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal Muller cell morphology ( J:91498 )

• more Muller cells are observed in the retina

nervous system

abnormal Muller cell morphology ( J:91498 )

• more Muller cells are observed in the retina

Allelic Composition	Vsx2^or-J/Vsx2^or-J Modor1^CASA/Rk/?
Genetic Background	involves: 129X1/SvJ * CASA/Rk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Modor1^CASA/Rk mutation (0 available); any Modor1 mutation (0 available)
Vsx2^or-J mutation (1 available); any Vsx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye size ( J:109796 )

• increased eye weight

• milder presentation of blindness and microphthalmia phenotype typical of Chx10^or-J mutation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13