Phenotypes associated with this allele

• Allele Symbol: Oca2^p-x
• Allele Name: pink-eyed dilution extra dark
• Allele ID: MGI:1856124
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oca2^p-x/Oca2^p-x	C3H101H-Oca2^p-x/H	MGI:3829200
ht2	Oca2^p-23DFiOD/Oca2^p-x	Not Specified	MGI:3043592
ht3	Oca2^p-30PUb/Oca2^p-x	Not Specified	MGI:3043594

Genotype
MGI:3829200

hm1

• Allelic Composition: Oca2^p-x/Oca2^p-x
• Genetic Background: C3H101H-Oca2^p-x/H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

decreased ear pigmentation ( J:15082 )

• only slightly lighter than wild-type

hearing/vestibular/ear

decreased ear pigmentation ( J:15082 )

• only slightly lighter than wild-type

pigmentation

decreased ear pigmentation ( J:15082 )

• only slightly lighter than wild-type

diluted coat color ( J:15082 )

• only slightly lighter than wild-type

abnormal eye pigmentation ( J:15082 )

• dark eyes at birth are difficult to differentiate from wild-type eye color

vision/eye

abnormal eye pigmentation ( J:15082 )

• dark eyes at birth are difficult to differentiate from wild-type eye color

integument

decreased ear pigmentation ( J:15082 )

• only slightly lighter than wild-type

diluted coat color ( J:15082 )

• only slightly lighter than wild-type

growth/size/body

decreased ear pigmentation ( J:15082 )

• only slightly lighter than wild-type

Genotype
MGI:3043592

ht2

• Allelic Composition: Oca2^p-23DFiOD/Oca2^p-x
• Genetic Background: Not Specified

adipose tissue

increased total fat pad weight ( J:66645 )

• fat pat weights were increased as much as 2 fold when this deletion was inherited maternally

hematopoietic system

increased spleen weight ( J:66645 )

• spleen weight was high when this deletion was inherited maternally

immune system

increased spleen weight ( J:66645 )

• spleen weight was high when this deletion was inherited maternally

liver/biliary system

increased liver weight ( J:66645 )

• liver weight was high when this deletion was inherited maternally

renal/urinary system

increased kidney weight ( J:66645 )

• kidney weight was high when this deletion was inherited maternally

growth/size/body

increased kidney weight ( J:66645 )

• kidney weight was high when this deletion was inherited maternally

increased liver weight ( J:66645 )

• liver weight was high when this deletion was inherited maternally

increased spleen weight ( J:66645 )

• spleen weight was high when this deletion was inherited maternally

Genotype
MGI:3043594

ht3

• Allelic Composition: Oca2^p-30PUb/Oca2^p-x
• Genetic Background: Not Specified

adipose tissue

increased total fat pad weight ( J:89922 )

• fat pad weights in females were increased 2-2.5 fold when this deletion was inherited maternally

• male fat pad weights were normal but weight gain of fat pads when placed on a 10% fat diet was greater than in male controls

growth/size/body

increased body weight ( J:89922 )

• body weight was increased for both sexes at 12 weeks of age when this deletion was inherited maternally

increased kidney weight ( J:89922 )

• kidney weight was high for females but not males when this deletion was inherited maternally

increased liver weight ( J:89922 )

• liver weight was high for females but not males when this deletion was inherited maternally

increased spleen weight ( J:89922 )

• spleen weight was high for females but not males when this deletion was inherited maternally

hematopoietic system

increased spleen weight ( J:89922 )

• spleen weight was high for females but not males when this deletion was inherited maternally

homeostasis/metabolism

abnormal glucose homeostasis ( J:89922 )

hyperglycemia ( J:89922 )

• both sexes were hyperglycemic

increased circulating insulin level ( J:89922 )

• females with a 2.2X higher insulin level

• male levels were also increased when on a 10% fat diet

abnormal lipid homeostasis ( J:89922 )

abnormal circulating cholesterol level ( J:89922 )

• increased levels of unesterified cholesterol in males

abnormal circulating HDL cholesterol level ( J:89922 )

• higher HDL levels in males than in controls

increased circulating cholesterol level ( J:89922 )

• levels increased in males

increased circulating triglyceride level ( J:89922 )

• higher in males than in controls

immune system

increased spleen weight ( J:89922 )

• spleen weight was high for females but not males when this deletion was inherited maternally

liver/biliary system

increased liver weight ( J:89922 )

• liver weight was high for females but not males when this deletion was inherited maternally

hepatic steatosis ( J:89922 )

• fatty liver disease was observed when this deletion was inherited maternally

renal/urinary system

increased kidney weight ( J:89922 )

• kidney weight was high for females but not males when this deletion was inherited maternally