Analysis Tools
pigmentation
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• coat color is lighter than in the original pink eye mutants
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• eye pigment is reduced to approximately the same color as in the original pink eye mutants
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vision/eye
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• eye pigment is reduced to approximately the same color as in the original pink eye mutants
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reproductive system
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• electron microscopy reveals that acrosome development is frequently abnormal, the proacrosome is sometimes duplicated, the proacrosomal vesicle and underlying nuclear membrane are sometimes flattened or irregular in shape and vesicular inclusions can be seen in developing acrosomes
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• many spermatids have two or more nuclei and maturing sperm have abnormalities including giant sperm with multiple tails
• a small number of multinucleated giant rounded spermatids can be found in the germinal epithelium
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• fewer sperm tails are found in the lumina of the spermatic tubules indicative of a reduced number of spermatogonia and sperm
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• a small number of multinucleated giant rounded spermatids can be found in the germinal epithelium
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small testis
(
J:5219
)
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• testes are less than half the normal size
|
endocrine/exocrine glands
| N |
• histology of mammary gland hours after giving birth and the presence of milk in the pups' stomachs indicate that females lactate normally
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small testis
(
J:5219
)
|
|
• testes are less than half the normal size
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behavior/neurological
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• homozygotes are described as active, nervous a little uncoordinated
|
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• time lapse photography 12 to 24 hours after birth shows that homozygous mothers fail to make a nest of keep the pups together, although there is no hostility toward the pups
• females rarely have more than one litter and that litter is usually small with pups rarely surviving more than 24 hours
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growth/size/body
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• homozygotes are smaller at birth and most weigh less as adults than their littermate controls
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skeleton
| N |
• no malocclusion or dental defects are found
|
integument
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• coat color is lighter than in the original pink eye mutants
|
cellular
|
|
• electron microscopy reveals that acrosome development is frequently abnormal, the proacrosome is sometimes duplicated, the proacrosomal vesicle and underlying nuclear membrane are sometimes flattened or irregular in shape and vesicular inclusions can be seen in developing acrosomes
|
|
|
• many spermatids have two or more nuclei and maturing sperm have abnormalities including giant sperm with multiple tails
• a small number of multinucleated giant rounded spermatids can be found in the germinal epithelium
|
|
|
• fewer sperm tails are found in the lumina of the spermatic tubules indicative of a reduced number of spermatogonia and sperm
|
|
|
• a small number of multinucleated giant rounded spermatids can be found in the germinal epithelium
|
