Phenotypes associated with this allele

• Allele Symbol: Sptbn4^qv
• Allele Name: quivering
• Allele ID: MGI:1856132
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sptbn4^qv/Sptbn4^qv	either: (involves: BALB/c) or (involves: C57BL/10)	MGI:5617031
hm2	Sptbn4^qv/Sptbn4^qv	involves: CBA/Gr	MGI:3720870
hm3	Sptbn4^qv/Sptbn4^qv	Not Specified	MGI:5617054

Genotype
MGI:5617031

hm1

• Allelic Composition: Sptbn4^qv/Sptbn4^qv
• Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:167 )

• quivering becomes pronounced as mice age

ataxia ( J:167 )

• evident as early as 14 days of age

paralysis ( J:167 )

• from 30 days of age mice show hindlimb and tail stiffening in varying degrees

hindlimb paralysis ( J:167 )

• observed from 30 days of age

reproductive system

priapism ( J:167 )

• occurs in the majority of males several days before death

male infertility ( J:167 )

♂ • males have viable sperm but do not sire litters

♂ • posterior paralysis precludes normal copulation behavior

hearing/vestibular/ear

deafness ( J:167 )

immune system

eye inflammation ( J:167 )

• mice may develop eye infections

vision/eye

eye inflammation ( J:167 )

• mice may develop eye infections

mortality/aging

premature death ( J:167 )

• the majority of mice die before 5 months of age

Genotype
MGI:3720870

hm2

• Allelic Composition: Sptbn4^qv/Sptbn4^qv
• Genetic Background: involves: CBA/Gr

hearing/vestibular/ear

abnormal auditory brainstem response ( J:71549 )

• the initial ABR peak, which corresponds to the compound action potential of the eighth cranial nerve, is broadened and delayed and a second vaveform peak is sometimes present

Genotype
MGI:5617054

hm3

• Allelic Composition: Sptbn4^qv/Sptbn4^qv
• Genetic Background: Not Specified

hearing/vestibular/ear

deafness ( J:32693 )

• by experimantal elimination, deafness is due to a central auditory dysfunction associated with the superior olivary complex and lateral lemniscus