Phenotypes associated with this allele

• Allele Symbol: Sox18^Ra
• Allele Name: ragged
• Allele ID: MGI:1856135
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox18^Ra/Sox18^Ra	Not Specified	MGI:3575020
ht2	Sox18^Ra/Sox18^+	involves: AG/Cam	MGI:5643713
ht3	Sox18^Ra/Sox18^+	Not Specified	MGI:3575021

Genotype
MGI:3575020

hm1

• Allelic Composition: Sox18^Ra/Sox18^Ra
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:86 )

• almost all die before weaning, but rare survivors are able to breed

integument

alopecia ( J:86 )

• animals are nearly hairless

homeostasis/metabolism

edema ( J:86 )

• many homozygous mutants show generalized edema at birth and die before weaning

Genotype
MGI:5643713

ht2

• Allelic Composition: Sox18^Ra/Sox18⁺
• Genetic Background: involves: AG/Cam

homeostasis/metabolism

chylous ascites ( J:6220 , J:13089 )

• Background Sensitivity: found among mice at N3 backcross to AG/Cam (J:6220)

• Background Sensitivity: ascites is not seen in mice at N5 backcross to AG/Cam (J:6220)

• Background Sensitivity: found among 1 in 10 heterozygous mice at N3 backcross to AG/Cam (J:13089)

• Background Sensitivity: mice appeared normal at birth but after first suckling abdomens swelled and milk-like fluid accumulated in the peritoneal cavity around the loops of the intestine (J:13089)

• Background Sensitivity: the amount of ascites fluid is variable (J:13089)

digestive/alimentary system

intestinal fibrosis ( J:13089 )

• observed in adult mice that survive severe neonatal chylous ascites

integument

retarded hair growth ( J:13089 )

• hair growth in some 2 to 4 week old mice is more compromised than expected for a heterozygous phenotype

adipose tissue

decreased total body fat amount ( J:13089 )

• a general deficiency of fat is noted in some 2 to 4 week old mice then expected for a heterozygous phenotype

Genotype
MGI:3575021

ht3

• Allelic Composition: Sox18^Ra/Sox18⁺
• Genetic Background: Not Specified

pigmentation

darkened coat color ( J:86 )

• agouti pattern is modified, the entire coat being unusually dark

• due to abnormal hair growth exposing lower non-agouti hair shaft

integument

absent auchene hairs ( J:86 )

darkened coat color ( J:86 )

• agouti pattern is modified, the entire coat being unusually dark

• due to abnormal hair growth exposing lower non-agouti hair shaft

retarded hair growth ( J:86 )

• the first coat develops a little more slowly than normal

sparse hair ( J:86 )

• absence of auchene and zigzag hairs results in a coat with a thin, ragged appearance

abnormal zigzag hair morphology ( J:86 )

• nearly absent

abnormal hair follicle morphology ( J:12991 )

• growth of the late differentiating hair follicles which produce auchenes and zigzags is very retarded or arrested

homeostasis/metabolism

chylous ascites ( J:13089 )

• Background Sensitivity: two large group studies on different mixed background showed the frequency of ascites to be 11.1% and 17.8%