Phenotypes associated with this allele

• Allele Symbol: Sox18^Ra-Op
• Allele Name: opossum
• Allele ID: MGI:1856136
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox18^Ra-Op/Sox18^Ra-Op	B6D2-Sox18^Ra-Op/J	MGI:3850351
hm2	Sox18^Ra-Op/Sox18^Ra-Op	involves: C57BL/6J * DBA/2J	MGI:3850333
ht3	Sox18^Ra-Op/Sox18^+	involves: C57BL/6J * DBA/2J	MGI:3850334

Genotype
MGI:3850351

hm1

• Allelic Composition: Sox18^Ra-Op/Sox18^Ra-Op
• Genetic Background: B6D2-Sox18^Ra-Op/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:143564 , J:150211 )

• mice die before E14.5 (J:143564)

• mice do not survive beyond E14.5 (J:150211)

cardiovascular system

cardiovascular system phenotype ( J:150211 )

N • between E8.5 and E10.5, differentiation, proliferation, migration and association of endothelial cells, and patterning and establishment of the primary vascular plexus is normal

abnormal blood vessel morphology ( J:150211 )

• at E12.5, 67% of mice exhibit enlarged surface microvasculature in the trunk, head, proximal limb and neck unlike in wild-type mice

• subdermal microvasculature diameter is increased 21% at E12.5 and 35% at E13.5 compared to in wild-type mice

• vascular defects increase in severity with age

• at E13.5, all mice exhibit enlarged surface microvasculature compared to in wild-type mice

• at E14.5, surface microvessels, particularly around the anterior cranial region, are enlarged compared to in wild-type mice

• enlarged blood vessels frequently rupture

increased vascular endothelial cell number ( J:150211 )

• endothelial hyperplasia is associated with defects in pericyte recruitment

abnormal pericyte morphology ( J:150211 )

• fewer pericytes are recruited to microvasculature compared to in wild-type mice

hematoma ( J:150211 )

• over large areas of the trunk, neck, and head

hemorrhage ( J:150211 )

• at E13.5, mice exhibit multiple regions of vascular hemorrhage unlike in wild-type mice

• at E14.5, large-scale vascular hemorrhage is observed in all mice

• enlarged blood vessels frequently rupture

abnormal vascular endothelial cell physiology ( J:150211 )

• loss of vascular integrity is due to endothelial rupture

homeostasis/metabolism

edema ( J:150211 )

• generalized at E13.5

skin edema ( J:143564 , J:150211 )

• at E13.5 (J:143564)

• 63% of mice exhibit severe subcutaneous edema in the trunk and neck regions un like in wild-type mice (J:150211)

immune system

abnormal lymphatic vessel morphology ( J:143564 )

• lymphatic vessels are finer, denser, and more branched with more loops and fewer blind-ended sacs compared to in wild-type mice

integument

skin edema ( J:143564 , J:150211 )

• at E13.5 (J:143564)

• 63% of mice exhibit severe subcutaneous edema in the trunk and neck regions un like in wild-type mice (J:150211)

Genotype
MGI:3850333

hm2

• Allelic Composition: Sox18^Ra-Op/Sox18^Ra-Op
• Genetic Background: involves: C57BL/6J * DBA/2J

mortality/aging

preweaning lethality, complete penetrance ( J:260 )

• no mice are found (no time of observation provided)

embryonic lethality, complete penetrance ( J:279 )

• mice die at E11 or earlier

Genotype
MGI:3850334

ht3

• Allelic Composition: Sox18^Ra-Op/Sox18⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

mortality/aging

perinatal lethality, incomplete penetrance ( J:260 , J:279 )

• many mice are dead or dying shortly after birth (J:260)

• many mice are dead or dying at birth (J:279)

postnatal lethality, incomplete penetrance ( J:260 , J:279 )

• fewer than expected mice are present at weaning (J:260)

• edematous mice die prior to weaning (J:279)

growth/size/body

decreased body size ( J:260 , J:279 )

• mice are smaller than normal from birth up to three months of age (J:260)

• at weaning mice are two-thirds the size of wild-type mice (J:260)

distended abdomen ( J:279 )

• mice that die prior to weaning exhibit swollen abdomens with perintoneal cavities filled with thin, white liquid unlike in wild-type mice

homeostasis/metabolism

cyanosis ( J:260 )

• in some mice at birth

edema ( J:260 , J:279 )

• at birth, some mice are edematous (J:260)

• mice that die around birth are edematous in the neck, shoulders, and abdominal and pleural cavities (J:260)

skin edema ( J:260 )

• mice that die around birth have edematous skin that is stretched, glossy, membranous in appearance, with red patches

integument

skin edema ( J:260 )

• mice that die around birth have edematous skin that is stretched, glossy, membranous in appearance, with red patches

absent auchene hairs ( J:260 )

abnormal awl hair morphology ( J:260 )

• mice have some awl hairs unlike in wild-type mice

abnormal hair growth ( J:260 , J:279 )

• asynchronous (J:260)

• asynchronous (J:279)

delayed hair appearance ( J:260 , J:279 )

• at 3 days of age, mice are still pink due to sparse coat unlike wild-type mice that have developed a coat (J:260)

• initiation of each follicle type is delayed compared to in wild-type mice (J:279)

sparse hair ( J:260 , J:279 )

abnormal zigzag hair morphology ( J:279 )

• some zigzag hairs are narrow, curled, lacked constrictions, and contain small medullar cells which lack pigment unlike in wild-type mice

decreased zigzag hair amount ( J:260 , J:279 )

• only a small patch on the shoulders (J:260)

• zigzag hairs are absent in the middle of the dorsum (J:279)

abnormal hair follicle morphology ( J:279 )

• mice lack follicles in the quiescent stage and are abnormal with bulbs that are twisted and curved unlike in wild-type mice

abnormal vibrissa morphology ( J:279 )

• at E17, mystacial vibrissa are incomplete and post-orbital vibrissa are absent or reduced in size compared to in wild-type mice

• mice lack inter-ramal and anterior supra-orbital vibrissa unlike wild-type mice

• postoral and posterior supra-orbital vibrassa are decreased in number compared to in wild-type mice

abnormal vibrissa number ( J:260 )

• anterior vibrissae and their follicles are absent unlike in wild-type mice

short vibrissae ( J:279 )

• at E17, post-orbital vibrissa are shorter than normal