integument
• cycles of normal hair regrowth with partial dorsal loss begins between 18 and 26 days of age
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• all hair types are affected
(J:15247)
• waviness is seen two days earlier than in the heterozygote and is more pronounced
(J:100076)
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• the shaft of all hair types is irregular
• hair calibre and and septation of medulla varies continuously
• hair shafts twist and bend with parts showing swelling, flattening and longitudinal indentations
• both medulla and cortex have areas of dense pigmentation; where medullary structures break down, pigment aggregates on cortical ridges or is scattered
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• whiskers are more curved and irregular than in heterozygote
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