Phenotypes associated with this allele

• Allele Symbol: Bmp5^se
• Allele Name: short ear
• Allele ID: MGI:1856150
• Summary: 23 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp5^se/Bmp5^se	Ab/Gn	MGI:3587796
hm2	Bmp5^se/Bmp5^se	C/Gn	MGI:3587794
hm3	Bmp5^se/Bmp5^se	involves: C3H * P	MGI:3587814
hm4	Bmp5^se/Bmp5^se	NB	MGI:3587807
hm5	Bmp5^se/Bmp5^se	Not Specified	MGI:3587431
hm6	Bmp5^se/Bmp5^se	P/J	MGI:3587806
hm7	Bmp5^se/Bmp5^se	SEAC/Gn	MGI:3587904
hm8	Bmp5^se/Bmp5^se	SEA/Gn	MGI:3587901
hm9	Bmp5^se/Bmp5^se	SEC/1Gn	MGI:3587818
hm10	Bmp5^se/Bmp5^se	SEC/Gn	MGI:3587817
ht11	Bmp5^se/Bmp5^+	SEAC/Gn	MGI:3587912
ht12	Bmp5^se/Bmp5^T27H	involves: 101/H * C3H/HeH	MGI:4822385
ht13	Bmp5^se/Bmp5^se-5RD300H	involves: 101/Rl * C3H/Rl	MGI:4822377
ht14	Bmp5^se/Bmp5^se-15THO-I	involves: 101/Rl * C3H/Rl	MGI:4436878
ht15	Bmp5^se/Bmp5^se-52CoS	involves: 101/Rl * C3H/Rl	MGI:4822391
ht16	Bmp5^se/Bmp5^se-x	involves: 101/Rl * C3H/Rl	MGI:4822397
ht17	Bmp5^se/Bmp5^se-32DTD	involves: 101/Rl * C3H/Rl	MGI:4822409
ht18	Bmp5^se/Bmp5^se-1FrThc	involves: 101/Rl * C3H/Rl	MGI:4822420
ht19	Bmp5^se/Bmp5^se-19H	involves: C3H/HeH	MGI:5299239
ht20	Bmp5^se/Bmp5^se-20H	involves: C3H/HeH	MGI:5299241
cx21	In(9Bmp5-Myo6)5Rl/Bmp5^se Myo6^sv	involves: 101/Rl * C3H/Rl	MGI:4436868
cx22	Bmp5^se/Bmp5^se Bmp6^tm1Rob/Bmp6^tm1Rob	involves: 129S/SvEv	MGI:3811522
cx23	Bmp5^se Myo6^sv/Bmp5^se Myo6^sv	involves: B10.HA/(33NX)Sn * C57BL/6J	MGI:5433383

Genotype
MGI:3587796

hm1

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: Ab/Gn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

small ears ( J:13091 )

growth/size/body

short nasal bone ( J:13091 )

small ears ( J:13091 )

decreased body size ( J:13091 )

• shorter total length, body length, tail length and psv length

decreased body weight ( J:13091 )

skeleton

small cranium ( J:13091 )

abnormal hyoid bone lesser horn morphology ( J:13091 )

• the lesser cornua of the hyoid bone is reduced

short nasal bone ( J:13091 )

abnormal humerus morphology ( J:13091 )

absent ulna ( J:13091 )

• Background Sensitivity: ulnar sesamoid bone is nearly always absent on the Ab background and is reduced in size on the C background

short ulna ( J:13091 )

• ulna is shorter in males

abnormal femur morphology ( J:13091 )

• medial sesamoid bone of the distal end of the femur is reduced in size

abnormal fibula morphology ( J:13091 )

• peroneal process of fibula is reduced in size or is absent

abnormal tibia morphology ( J:13091 )

• curvature of tibia is much less pronounced than in controls

abnormal laryngeal cartilage morphology ( J:13091 )

• larygeal cartilage have a less dense appearance

small cricoid cartilage ( J:13091 )

• size is reduced

small thyroid cartilage ( J:13091 )

• size is reduced

decreased diameter of long bones ( J:13091 )

• thinner long bones except for ulna in females

decreased diameter of humerus ( J:13091 )

• humerus width is reduced in both sexes

increased length of long bones ( J:13091 )

• longer long bones except for ulna in males

long humerus ( J:13091 )

• the length is longer in females but not males

long tibia ( J:13091 )

abnormal sternebra morphology ( J:13091 )

• Background Sensitivity: about 12% have the 4th and 5th sternebrae fused to give only 4 sternebrae anterior to the xiphisternum

• the omosternum is either absent or very small

abnormal rib development ( J:100198 )

• the 13th pair of ribs is incompletely developed

decreased rib number ( J:100198 )

• 35% of homozygotes have no 13th rib

abnormal vertebrae morphology ( J:13091 )

• Background Sensitivity: number of sacral and caudal vertebrae is reduced at 30 days of age but not at 3 months of age on the Ab background and no differences are observed on the C background

abnormal thoracic vertebrae morphology ( J:13091 )

• size of the dorsal spine of the 2nd thoracic vertebra is variable

abnormal cervical vertebrae morphology ( J:13091 )

• Background Sensitivity: inferior lamella of the 6th cervical vertebra is usually absent on the Ab background and sometimes absent on the C background

abnormal vertebral spinous process morphology ( J:13091 )

• size of the dorsal spine of the 2nd thoracic vertebra is variable

limbs/digits/tail

abnormal humerus morphology ( J:13091 )

decreased diameter of humerus ( J:13091 )

• humerus width is reduced in both sexes

long humerus ( J:13091 )

• the length is longer in females but not males

absent ulna ( J:13091 )

• Background Sensitivity: ulnar sesamoid bone is nearly always absent on the Ab background and is reduced in size on the C background

short ulna ( J:13091 )

• ulna is shorter in males

abnormal femur morphology ( J:13091 )

• medial sesamoid bone of the distal end of the femur is reduced in size

abnormal fibula morphology ( J:13091 )

• peroneal process of fibula is reduced in size or is absent

abnormal tibia morphology ( J:13091 )

• curvature of tibia is much less pronounced than in controls

long tibia ( J:13091 )

short tail ( J:13091 )

liver/biliary system

decreased liver weight ( J:13091 )

renal/urinary system

abnormal kidney morphology ( J:13091 )

• kidneys often have two or more papillae

hydronephrosis ( J:13091 )

• varying degrees of hydronephrosis

respiratory system

short nasal bone ( J:13091 )

abnormal larynx morphology ( J:13091 )

• certain fenestrae of the larynx are larger

abnormal laryngeal cartilage morphology ( J:13091 )

• larygeal cartilage have a less dense appearance

small cricoid cartilage ( J:13091 )

• size is reduced

small thyroid cartilage ( J:13091 )

• size is reduced

craniofacial

small cranium ( J:13091 )

abnormal hyoid bone lesser horn morphology ( J:13091 )

• the lesser cornua of the hyoid bone is reduced

short nasal bone ( J:13091 )

small ears ( J:13091 )

Genotype
MGI:3587794

hm2

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: C/Gn

skeleton

abnormal hyoid bone lesser horn morphology ( J:13091 )

• the lesser cornua of the hyoid bone is reduced

abnormal laryngeal cartilage morphology ( J:13091 )

• larygeal cartilage have a less dense appearance

small cricoid cartilage ( J:13091 )

• size is reduced

small thyroid cartilage ( J:13091 )

• size is reduced

abnormal long bone morphology ( J:13091 )

short ulna ( J:13091 )

• Background Sensitivity: ulnar sesamoid bone is reduced in size on the C background and nearly always absent on the Ab background

abnormal femur morphology ( J:13091 )

• medial sesamoid bone of the distal end of the femur is reduced in size

abnormal fibula morphology ( J:13091 )

• peroneal process of fibula is reduced in size or is absent

abnormal sternebra morphology ( J:13091 )

• Background Sensitivity: the extra 6th sternebrae anterior to the xiphisternum that is sometimes seen in controls, is never observed and the 4th and 5th sternebrae are sometimes fused

abnormal cervical vertebrae morphology ( J:13091 )

• Background Sensitivity: inferior lamella of the 6th cervical vertebra is sometimes absent on the C background and usually absent on the Ab background

limbs/digits/tail

short ulna ( J:13091 )

• Background Sensitivity: ulnar sesamoid bone is reduced in size on the C background and nearly always absent on the Ab background

abnormal femur morphology ( J:13091 )

• medial sesamoid bone of the distal end of the femur is reduced in size

abnormal fibula morphology ( J:13091 )

• peroneal process of fibula is reduced in size or is absent

respiratory system

abnormal larynx morphology ( J:13091 )

• certain fenestrae of the larynx are larger

abnormal laryngeal cartilage morphology ( J:13091 )

• larygeal cartilage have a less dense appearance

small cricoid cartilage ( J:13091 )

• size is reduced

small thyroid cartilage ( J:13091 )

• size is reduced

craniofacial

abnormal hyoid bone lesser horn morphology ( J:13091 )

• the lesser cornua of the hyoid bone is reduced

Genotype
MGI:3587814

hm3

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: involves: C3H * P

hearing/vestibular/ear

abnormal outer ear morphology ( J:15478 )

• scapha, the annular cartilages of the meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• ears are shrunken and ruffled due to cartilage defects

growth/size/body

abnormal outer ear morphology ( J:15478 )

• scapha, the annular cartilages of the meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• ears are shrunken and ruffled due to cartilage defects

decreased body size ( J:15478 )

skeleton

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

abnormal cartilage development ( J:15478 )

• the basal part of the ear cartilage does not develop as well as in controls and is smaller and thinner by time of birth

• condenstation of mesenchyme leading to cartilage formation is defective in the xiphoid region of the sternal bands, in the annular cartilages of the meatus, and in the scapha

craniofacial

abnormal outer ear morphology ( J:15478 )

• scapha, the annular cartilages of the meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• ears are shrunken and ruffled due to cartilage defects

Genotype
MGI:3587807

hm4

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: NB

hearing/vestibular/ear

small ears ( J:15478 )

• Background Sensitivity: ears are small but slightly larger than on the P background

skeleton

abnormal xiphoid process morphology ( J:15478 )

• Background Sensitivity: xiphisternum is either very reduced or completely absent in the P/J background and is bifurcated in the NB background

craniofacial

small ears ( J:15478 )

• Background Sensitivity: ears are small but slightly larger than on the P background

growth/size/body

small ears ( J:15478 )

• Background Sensitivity: ears are small but slightly larger than on the P background

Genotype
MGI:3587431

hm5

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: Not Specified

hearing/vestibular/ear

abnormal ear shape ( J:14849 )

• pinna is less regularly curved and exhibits a flattening near the tip of the ear and in the outer margin

small ears ( J:14849 )

• pinna is about one half as long as wild-type and 1-2 mm less broad than in wild-type

short ears ( J:24474 )

thick ears ( J:14849 )

• pinna is usually thick and fleshy

homeostasis/metabolism

abnormal bone healing ( J:24474 )

• decreased repair of fractures

craniofacial

abnormal cranium morphology ( J:24474 )

• short skull

increased cranium width ( J:24474 )

abnormal ear shape ( J:14849 )

• pinna is less regularly curved and exhibits a flattening near the tip of the ear and in the outer margin

small ears ( J:14849 )

• pinna is about one half as long as wild-type and 1-2 mm less broad than in wild-type

short ears ( J:24474 )

thick ears ( J:14849 )

• pinna is usually thick and fleshy

limbs/digits/tail

abnormal limb bone morphology ( J:24474 )

• aplasia or hypoplasia of ulnar sesamoid bone in wrist

abnormal fibula morphology ( J:24474 )

• aplasia or hypoplasia of the peroneal process of the fibula

abnormal sesamoid bone of gastrocnemius morphology ( J:24474 )

• reduction or elimination of medial, but not lateral, sesamoid bone near knee

growth/size/body

abnormal ear shape ( J:14849 )

• pinna is less regularly curved and exhibits a flattening near the tip of the ear and in the outer margin

small ears ( J:14849 )

• pinna is about one half as long as wild-type and 1-2 mm less broad than in wild-type

short ears ( J:24474 )

thick ears ( J:14849 )

• pinna is usually thick and fleshy

decreased body size ( J:24474 )

skeleton

abnormal cranium morphology ( J:24474 )

• short skull

increased cranium width ( J:24474 )

abnormal bone healing ( J:24474 )

• decreased repair of fractures

abnormal limb bone morphology ( J:24474 )

• aplasia or hypoplasia of ulnar sesamoid bone in wrist

abnormal sesamoid bone of gastrocnemius morphology ( J:24474 )

• reduction or elimination of medial, but not lateral, sesamoid bone near knee

abnormal long bone morphology ( J:24474 )

• altered curves of long bones

abnormal fibula morphology ( J:24474 )

• aplasia or hypoplasia of the peroneal process of the fibula

decreased diameter of long bones ( J:24474 )

• smaller widths of long bones

absent xiphoid process ( J:24474 )

• xiphisternum is either absent or split

split xiphoid process ( J:24474 )

• xiphisternum is either absent or split

abnormal rib morphology ( J:24474 )

• rib defects

decreased rib number ( J:24474 )

abnormal sacrum morphology ( J:24474 )

• sacrum defect

abnormal vertebrae morphology ( J:24474 )

• vertebrae abnormalities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Meier-Gorlin syndrome		DOID:0060306	OMIM:PS224690	J:24474

Genotype
MGI:3587806

hm6

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: P/J

hearing/vestibular/ear

abnormal outer ear morphology ( J:15478 )

• scapha, the rings that surround the external auditory meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• Background Sensitivity: ears are smaller than in the NB background

• ear is shrunken and ruffled due to cartilage defects

skeleton

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

abnormal xiphoid process morphology ( J:15478 )

• Background Sensitivity: xiphisternum is either very reduced or completely absent in the P/J background and is bifurcated in the NB background

abnormal cartilage development ( J:15478 )

• the basal part of the ear cartilage does not develop as well as in controls and is smaller and thinner by time of birth

• condenstation of mesenchyme leading to cartilage formation is defective in the xiphoid region of the sternal bands, in the annular cartilages of the meatus, and in the scapha

craniofacial

abnormal outer ear morphology ( J:15478 )

• scapha, the rings that surround the external auditory meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• Background Sensitivity: ears are smaller than in the NB background

• ear is shrunken and ruffled due to cartilage defects

growth/size/body

abnormal outer ear morphology ( J:15478 )

• scapha, the rings that surround the external auditory meatus, the crus helicis and most of the basal part of the cartilage are all reduced

abnormal outer ear cartilage morphology ( J:15478 )

• cartilage is entirely absent in the scapha and reduced in size in all other parts of the ear

small ears ( J:15478 )

• Background Sensitivity: ears are smaller than in the NB background

• ear is shrunken and ruffled due to cartilage defects

Genotype
MGI:3587904

hm7

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: SEAC/Gn

cardiovascular system

abnormal aorta morphology ( J:5086 )

• the lateral branches of the aorta have a lower frequency of dorsal rami

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

embryo

abnormal embryonic tissue morphology ( J:5086 )

• crowding of the abdominal viscera in embryos

abnormal urogenital fold morphology ( J:5086 )

• both urogenital folds are abnormally shaped, being shorter and turned in more toward the midline than normal in embryos

umbilical hernia ( J:5086 )

• small umbilical hernia of the liver

endocrine/exocrine glands

ectopic ovary ( J:5086 )

♀ • the left ovary frequently is displaced and lies at the anterior medial border of the kidney with the mesovarium and mesometrium attached near the medial border of the kidney

unilateral cryptorchism ( J:5086 )

♂ • the left testis occasionally is undescended and remains in the abdominal cavity

immune system

granulomatous inflammation ( J:5086 )

• granulomas are seen on the ventral surface of the central and left lateral lobes of the liver

limbs/digits/tail

abnormal forelimb morphology ( J:5086 )

• many E15-E17 embryos have a small papilla on the ulnar side of the fifth digit of the forefoot

short humerus ( J:5086 )

short femur ( J:5086 )

liver/biliary system

abnormal liver morphology ( J:5086 )

• increase in liver lesions, mainly due to an increase in granulomas

• small umbilical hernia of the liver

renal/urinary system

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

hydronephrosis ( J:5086 )

• occasionally observe hydronephrosis

hydroureter ( J:5086 )

• occasionally observe hydroureter

reproductive system

ectopic ovary ( J:5086 )

♀ • the left ovary frequently is displaced and lies at the anterior medial border of the kidney with the mesovarium and mesometrium attached near the medial border of the kidney

unilateral cryptorchism ( J:5086 )

♂ • the left testis occasionally is undescended and remains in the abdominal cavity

respiratory system

lung cyst ( J:5086 )

• have numerous small cysts in the lungs

skeleton

short humerus ( J:5086 )

short femur ( J:5086 )

growth/size/body

lung cyst ( J:5086 )

• have numerous small cysts in the lungs

Genotype
MGI:3587901

hm8

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: SEA/Gn

cardiovascular system

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

renal/urinary system

abnormal right renal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

hydronephrosis ( J:5086 )

• observed occasionally

hydroureter ( J:5086 )

• observed occasionally

Genotype
MGI:3587818

hm9

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: SEC/1Gn

skeleton

abnormal cartilage development ( J:13011 )

• cartilage forms more slowly in healing rib fractures

cardiovascular system

abnormal artery morphology ( J:5086 )

• the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls

immune system

granulomatous inflammation ( J:5086 )

• granulomas are seen on the ventral surface of the central and left lateral lobes of the liver

liver/biliary system

abnormal liver morphology ( J:5086 )

• increase in liver lesions, mainly due to an increase in granulomas

respiratory system

lung cyst ( J:5086 )

• have numerous small cysts in the lungs

growth/size/body

lung cyst ( J:5086 )

• have numerous small cysts in the lungs

Genotype
MGI:3587817

hm10

• Allelic Composition: Bmp5^se/Bmp5^se
• Genetic Background: SEC/Gn

skeleton

abnormal cartilage development ( J:13011 )

• cartilage forms more slowly in healing rib fractures

abnormal bone ossification ( J:13011 )

• reduced rate of proliferation of osteogenic cells of the periosteum in healing rib fractures

Genotype
MGI:3587912

ht11

• Allelic Composition: Bmp5^se/Bmp5⁺
• Genetic Background: SEAC/Gn

limbs/digits/tail

short humerus ( J:5086 )

• shorter than in controls but longer than in homozygotes

short femur ( J:5086 )

• shorter than in controls but longer than in homozygotes

skeleton

short humerus ( J:5086 )

• shorter than in controls but longer than in homozygotes

short femur ( J:5086 )

• shorter than in controls but longer than in homozygotes

Genotype
MGI:4822385

ht12

• Allelic Composition: Bmp5^se/Bmp5^T27H
• Genetic Background: involves: 101/H * C3H/HeH

craniofacial

short ears ( J:3046 )

• short ears, similar to Bmp5^se homozygous mice

hearing/vestibular/ear

short ears ( J:3046 )

• short ears, similar to Bmp5^se homozygous mice

growth/size/body

short ears ( J:3046 )

• short ears, similar to Bmp5^se homozygous mice

Genotype
MGI:4822377

ht13

• Allelic Composition: Bmp5^se/Bmp5^se-5RD300H
• Genetic Background: involves: 101/Rl * C3H/Rl

craniofacial

small ears ( J:100221 )

hearing/vestibular/ear

small ears ( J:100221 )

growth/size/body

small ears ( J:100221 )

Genotype
MGI:4436878

ht14

• Allelic Composition: Bmp5^se/Bmp5^se-15THO-I
• Genetic Background: involves: 101/Rl * C3H/Rl

craniofacial

short ears ( J:100221 )

• described as short

hearing/vestibular/ear

short ears ( J:100221 )

• described as short

growth/size/body

short ears ( J:100221 )

• described as short

Genotype
MGI:4822391

ht15

• Allelic Composition: Bmp5^se/Bmp5^se-52CoS
• Genetic Background: involves: 101/Rl * C3H/Rl

craniofacial

small ears ( J:100221 )

• resembles Bmp5^se homozygous mice

hearing/vestibular/ear

small ears ( J:100221 )

• resembles Bmp5^se homozygous mice

growth/size/body

small ears ( J:100221 )

• resembles Bmp5^se homozygous mice

Genotype
MGI:4822397

ht16

• Allelic Composition: Bmp5^se/Bmp5^se-x
• Genetic Background: involves: 101/Rl * C3H/Rl

craniofacial

short ears ( J:12013 )

• heterozygous Bmp5^se/Bmp5^se-x mice have short ears like Bmp5^se homozygotes or possibly a little longer

hearing/vestibular/ear

short ears ( J:12013 )

• heterozygous Bmp5^se/Bmp5^se-x mice have short ears like Bmp5^se homozygotes or possibly a little longer

growth/size/body

short ears ( J:12013 )

• heterozygous Bmp5^se/Bmp5^se-x mice have short ears like Bmp5^se homozygotes or possibly a little longer

Genotype
MGI:4822409

ht17

• Allelic Composition: Bmp5^se/Bmp5^se-32DTD
• Genetic Background: involves: 101/Rl * C3H/Rl

craniofacial

small ears ( J:100221 )

• resembles Bmp5^se homozygous mice

hearing/vestibular/ear

small ears ( J:100221 )

• resembles Bmp5^se homozygous mice

growth/size/body

small ears ( J:100221 )

• resembles Bmp5^se homozygous mice

Genotype
MGI:4822420

ht18

• Allelic Composition: Bmp5^se/Bmp5^se-1FrThc
• Genetic Background: involves: 101/Rl * C3H/Rl

craniofacial

small ears ( J:45426 )

• viable and resemble Bmp5^se homozygous mice

hearing/vestibular/ear

small ears ( J:45426 )

• viable and resemble Bmp5^se homozygous mice

growth/size/body

small ears ( J:45426 )

• viable and resemble Bmp5^se homozygous mice

Genotype
MGI:5299239

ht19

• Allelic Composition: Bmp5^se/Bmp5^se-19H
• Genetic Background: involves: C3H/HeH

mortality/aging

mortality/aging ( J:90559 )

N • mice are viable and resemble Bmp^se homozygotes

craniofacial

short ears ( J:90559 )

• short ears

hearing/vestibular/ear

short ears ( J:90559 )

• short ears

growth/size/body

short ears ( J:90559 )

• short ears

Genotype
MGI:5299241

ht20

• Allelic Composition: Bmp5^se/Bmp5^se-20H
• Genetic Background: involves: C3H/HeH

mortality/aging

preweaning lethality ( J:90559 )

• likely prenatally

Genotype
MGI:4436868

cx21

• Allelic Composition: In(9Bmp5-Myo6)5Rl/Bmp5^se Myo6^sv
• Genetic Background: involves: 101/Rl * C3H/Rl

behavior/neurological

circling ( J:100221 )

• waltzer-like; resembles Myo6^sv

craniofacial

short ears ( J:100221 )

• described as short ears

hearing/vestibular/ear

short ears ( J:100221 )

• described as short ears

impaired hearing ( J:100221 )

growth/size/body

short ears ( J:100221 )

• described as short ears

Genotype
MGI:3811522

cx22

• Allelic Composition: Bmp5^se/Bmp5^se; Bmp6^tm1Rob/Bmp6^tm1Rob
• Genetic Background: involves: 129S/SvEv

growth/size/body

postnatal growth retardation ( J:48561 )

• slight growth reduction

skeleton

abnormal sternum morphology ( J:48561 )

• delayed fusion of sternal bands

abnormal xiphoid process morphology ( J:48561 )

small xiphoid process ( J:48561 )

• reduced xiphoid process at E17.5

split xiphoid process ( J:48561 )

• at E17.5

abnormal sternum ossification ( J:48561 )

• at E17.5

reproductive system

male infertility ( J:48561 )

♂ • males are sterile whereas females are fertile

Genotype
MGI:5433383

cx23

• Allelic Composition: Bmp5^se Myo6^sv/Bmp5^se Myo6^sv
• Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

mortality/aging

prenatal lethality, incomplete penetrance ( J:5044 )

• The percentage of double homozygotes generated from crosses of double homozygotes with double heterozgyotes in coupling is significantly lower than Mendelian prediction indicating prenatal lethality in the compound homozygote more severe than in either single homozygote