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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		KitlSl
steel
MGI:1856161
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		KitlSl/KitlSl involves: C3H MGI:2387143
ht2
 		KitlSl/Kitl+ either: (involves: C3H * WC) or (involves: C3H * C57BL/6 * DBA/2J * WC) MGI:3690621
ht3
 		KitlSl/Kitl+ involves: 129/Sv * C3H MGI:3690647
ht4
 		KitlSl/Kitl+ involves: C3H MGI:2387145
ht5
 		Kitltm2.1Pbes/KitlSl involves: 129S1/Sv * C3H * C57BL/6J * FVB/N MGI:4430870
ht6
 		KitlSl/KitlSl-17J involves: BALB/cGr * C3HeB/FeJ MGI:5308814
ht7
 		KitlSl/KitlSl-d involves: C3H * C57BL/6 * DBA/2J * WC MGI:3690619
ht8
 		KitlSl/KitlSl-d involves: C57BL/6 * WC MGI:2387022
ht9
 		KitlSl/KitlSl-Clo Not Specified MGI:5284822
ht10
 		KitlSl/KitlSl-d (WC/ReJ KitlSl x B6.D2-KitlSl-d/J)F1-KitlSl/KitlSl-d/J MGI:3690850
cx11
 		Baxtm1Sjk/Bax+
KitlSl/KitlSl
Tg(Pou5f1-GFP)1Scho/? 		involves: 129X1/SvJ * C3H * CD-1 * FVB MGI:3693198
cx12
 		Baxtm1Sjk/Baxtm1Sjk
KitlSl/KitlSl
Tg(Pou5f1-GFP)1Scho/? 		involves: 129X1/SvJ * C3H * CD-1 * FVB MGI:3693197
cx13
 		KitlSl/Kitl+
Tg(PGK1-KITLG*220)441Daw/0 		involves: C3H MGI:3817636


Genotype
MGI:2387143
hm1
Allelic
Composition		 KitlSl/KitlSl
Genetic
Background		 involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:3399 )
• no presumed homozygotes are born; homozygotes begin to die at ~E15-15.5 from anemia
• an occasional mutant survives until birth

nervous system
spina bifida ( J:3399 )
• 4/330 embryos aged E14.5-17.5 displayed spina bifida
abnormal brain development ( J:3399 )
• at E10.5-12.5, small number of embryos, presumably homozygous, have brain abnormalities, including a collapsed brain, pseudoencephaly or a narrowed brain region
• from E14.5-17.5, some embryos show abnormal brain development (3/330) as described in younger embryos
myelencephalic blebs ( J:3399 )
• one E17.5 embryo displayed a bleb near the midline in the cervical region

hematopoietic system
anemia ( J:3399 )
• starting around E13.5 and peaking at E14.5, presumed homozygotes display anemia recognized by overall paleness of the embryos

cardiovascular system
abnormal blood circulation ( J:3399 )
• in affected (anemic) animals, individual clumps or red blood cells can be seen in umbilical vessels; in controls, vessels are uniformly red with normal blood flow

reproductive system
infertility ( J:5547 )
• mice carrying two mutant alleles are sterile

pigmentation
absent skin pigmentation ( J:28098 )
• transplantation of skin grafts from E14, E15 and newborn mutants to normal siblings produced unpigmented hair

embryo
spina bifida ( J:3399 )
• 4/330 embryos aged E14.5-17.5 displayed spina bifida

integument
pallor ( J:3399 )
• characteristic of anemic embryos
absent skin pigmentation ( J:28098 )
• transplantation of skin grafts from E14, E15 and newborn mutants to normal siblings produced unpigmented hair




Genotype
MGI:3690621
ht2
Allelic
Composition		 KitlSl/Kitl+
Genetic
Background		 either: (involves: C3H * WC) or (involves: C3H * C57BL/6 * DBA/2J * WC)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:6084 )
• mice are slightly anemic
decreased mast cell number ( J:6084 )
• heterozygotes have decreased mast cell numbers in dorsal skin compared to wild-type

immune system
decreased mast cell number ( J:6084 )
• heterozygotes have decreased mast cell numbers in dorsal skin compared to wild-type




Genotype
MGI:3690647
ht3
Allelic
Composition		 KitlSl/Kitl+
Genetic
Background		 involves: 129/Sv * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:50508 )
• male mice develop ~2-fold more tumors than controls
increased testicular teratoma incidence ( J:50508 )
• incidence is 6.92% compared to ~2.6% in controls
• tumors are predominantly in left testis (71%) vs right (27%) or bilateral (2%)
• percentage is greater in second and subsequent litters compared to first litter or in first litter of older females compared to young mothers

reproductive system
increased testicular teratoma incidence ( J:50508 )
• incidence is 6.92% compared to ~2.6% in controls
• tumors are predominantly in left testis (71%) vs right (27%) or bilateral (2%)
• percentage is greater in second and subsequent litters compared to first litter or in first litter of older females compared to young mothers

endocrine/exocrine glands
increased testicular teratoma incidence ( J:50508 )
• incidence is 6.92% compared to ~2.6% in controls
• tumors are predominantly in left testis (71%) vs right (27%) or bilateral (2%)
• percentage is greater in second and subsequent litters compared to first litter or in first litter of older females compared to young mothers




Genotype
MGI:2387145
ht4
Allelic
Composition		 KitlSl/Kitl+
Genetic
Background		 involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
decreased ear pigmentation ( J:3399 )
• mice have light ears
diluted coat color ( J:3399 , J:157170 )
• affected mice have overall dilution of coat color, more extreme on the belly than back (J:3399)
• reduced coat color (J:157170)
head blaze ( J:3399 )
• very occasionally mice have a white blaze between their eyes
belly spot ( J:3399 , J:157170 )
• most mice have a white spot on the belly (J:3399)
head spot ( J:3399 )
• most mice have a white spot on the belly
decreased foot pigmentation ( J:3399 )
• mice have light feet

hematopoietic system
anemia ( J:3399 )
• mice display less severe anemia than homozygotes
decreased erythrocyte cell number ( J:3399 )
• at 7-13 days of age, red blood cell counts are 20-30% lower than wild-type

hearing/vestibular/ear
decreased ear pigmentation ( J:3399 )
• mice have light ears

reproductive system
reproductive system phenotype ( J:3399 )
N
• heterozygotes are viable and fertile

craniofacial
decreased ear pigmentation ( J:3399 )
• mice have light ears

integument
decreased ear pigmentation ( J:3399 )
• mice have light ears
diluted coat color ( J:3399 , J:157170 )
• affected mice have overall dilution of coat color, more extreme on the belly than back (J:3399)
• reduced coat color (J:157170)
head blaze ( J:3399 )
• very occasionally mice have a white blaze between their eyes
belly spot ( J:3399 , J:157170 )
• most mice have a white spot on the belly (J:3399)
head spot ( J:3399 )
• most mice have a white spot on the belly
abnormal vibrissa morphology ( J:3399 )
• mice have light whiskers
pallor ( J:3399 )
• some pups after birth are pale compared to littermates
decreased foot pigmentation ( J:3399 )
• mice have light feet

growth/size/body
decreased ear pigmentation ( J:3399 )
• mice have light ears




Genotype
MGI:4430870
ht5
Allelic
Composition		 Kitltm2.1Pbes/KitlSl
Genetic
Background		 involves: 129S1/Sv * C3H * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
Kitltm2.1Pbes mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:157170 )
• absence of developing germ cells in the testis and mature sperm in the epididymis in adult mice
• morphologically normal testes at 4 week old

pigmentation

integument

cellular
azoospermia ( J:157170 )
• absence of developing germ cells in the testis and mature sperm in the epididymis in adult mice
• morphologically normal testes at 4 week old




Genotype
MGI:5308814
ht6
Allelic
Composition		 KitlSl/KitlSl-17J
Genetic
Background		 involves: BALB/cGr * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
KitlSl-17J mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
absent coat pigmentation ( J:79402 )
• mice of this complementation test genotype are white, the normal black eyes prominent against the coat

pigmentation
absent coat pigmentation ( J:79402 )
• mice of this complementation test genotype are white, the normal black eyes prominent against the coat




Genotype
MGI:3690619
ht7
Allelic
Composition		 KitlSl/KitlSl-d
Genetic
Background		 involves: C3H * C57BL/6 * DBA/2J * WC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
KitlSl-d mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mast cell number ( J:6084 )
• in early postnatal mice, mast cell number in skin is ~4% of wild-type number
• adult mice have <1% of numbers in wild-type mice
• no mast cells are detected in stomachs and mesenteries of adult mutants; none are found in cecum, bone marrow, spleen, thymus, heart, lung, kidney, liver or brain in mutants of various ages

immune system
decreased mast cell number ( J:6084 )
• in early postnatal mice, mast cell number in skin is ~4% of wild-type number
• adult mice have <1% of numbers in wild-type mice
• no mast cells are detected in stomachs and mesenteries of adult mutants; none are found in cecum, bone marrow, spleen, thymus, heart, lung, kidney, liver or brain in mutants of various ages
abnormal response to transplant ( J:6084 )
• after receiving skin grafts from Kit/Kit donors, a significant increase in mast cell number in skin is seen, compared no increase observed in reciprocal transplant




Genotype
MGI:2387022
ht8
Allelic
Composition		 KitlSl/KitlSl-d
Genetic
Background		 involves: C57BL/6 * WC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
KitlSl-d mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:5758 )
• 69% of mice live until 4 weeks of age, and 59% survive to 5 months; life span of mice reaching 5 months is reduced 51% vs wild-type
• 88% of mice die from leukemia or ulcerative dermatitis

growth/size/body
weight loss ( J:5758 )
• dermatitis is accompanied by weight loss

hematopoietic system
thymus atrophy ( J:5758 )
• at autopsy, thymic atrophy was observed in mice that developed ulcerative dermatitis
anemia ( J:2777 , J:27511 )
• packed cell volumes (PCVs) are 28.8 compared to ~45 for controls (J:2777)
• surviving mice show macrocytic anemia (J:27511)
decreased hematocrit ( J:27511 )
• hematocrit is lower than normal (~29%) and have lower than normal numbers of macrocytic erythrocytes
reticulocytosis ( J:27511 )
• reticulocyte percentages are higher (8-12%) than in KitlW/KitlW-v mice

reproductive system
reproductive system phenotype ( J:5547 )
N
• although mutants show a severe deficiency of primordial germ cells (PGCs), migration remaining PGCs from gut endoderm to gonadal ridges appears normal
decreased primordial germ cell number ( J:5547 )
• mean of total PGC counts in embryos on E9 do not differ from mutant counts on E10 and E11; however, means of counts from normal embryos on E10 and E11 are 3 and 8-fold higher than day 9 mean PGC count, indicating a paucity of PGCs in mutants
infertility ( J:5547 )
• mice carrying two mutant alleles at the Kitl locus are sterile

neoplasm
abnormal tumor incidence ( J:5758 )
• no mice develop reticulum cell neoplasms compared to 30% of controls at 889 days of age
increased leukemia incidence ( J:5758 )
• lymphocytic leukemia develops in mice (37%) at average age of 370 days vs 5% incidence in wild-type and heterozygous mice at 965 days of age
increased papilloma incidence ( J:2777 )
• mice develop gastric papillomas, with greater frequency than controls

immune system
stomach inflammation ( J:2777 )
• mixed inflammatory infiltrates are seen in lamina propria and submucosa of stomach
thymus atrophy ( J:5758 )
• at autopsy, thymic atrophy was observed in mice that developed ulcerative dermatitis
dermatitis ( J:5758 )
• progressive ulcerative dermatitis develops at average age of 441 days (56% incidence), predominantly on the head and neck and in the axilla vs 20% of controls at 772 days of age; only 5 mice displayed lymphocytic leukemia as well

digestive/alimentary system
abnormal forestomach morphology ( J:2777 )
• lamina propria of forestomach is mildly edematous with mixed inflammatory infiltrate
• all layers of forestomach are increased in thickness, but stratum spinosum and stratum corneum are most affected
abnormal stomach epithelium morphology ( J:2777 )
• forestomach is significantly thicker (187 um) than controls (40 um)
abnormal stomach non-glandular epithelium morphology ( J:2777 )
• nonglandular portion of forestomach is consists of stratified squamous epithelium that is significantly thicker than controls and appears as short folds extending into lamina propria in endophytic pattern
gastric ulcer ( J:2777 )
• one mutant had an ulcer in glandular portion of stomach
stomach inflammation ( J:2777 )
• mixed inflammatory infiltrates are seen in lamina propria and submucosa of stomach

integument
dermatitis ( J:5758 )
• progressive ulcerative dermatitis develops at average age of 441 days (56% incidence), predominantly on the head and neck and in the axilla vs 20% of controls at 772 days of age; only 5 mice displayed lymphocytic leukemia as well

endocrine/exocrine glands
thymus atrophy ( J:5758 )
• at autopsy, thymic atrophy was observed in mice that developed ulcerative dermatitis

cellular
decreased primordial germ cell number ( J:5547 )
• mean of total PGC counts in embryos on E9 do not differ from mutant counts on E10 and E11; however, means of counts from normal embryos on E10 and E11 are 3 and 8-fold higher than day 9 mean PGC count, indicating a paucity of PGCs in mutants




Genotype
MGI:5284822
ht9
Allelic
Composition		 KitlSl/KitlSl-Clo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
KitlSl-Clo mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat/hair pigmentation ( J:13654 )
• body is off-white but ears have the expected dark pigmentation
• eyes are black, normal pigmentation

pigmentation
abnormal coat/hair pigmentation ( J:13654 )
• body is off-white but ears have the expected dark pigmentation
• eyes are black, normal pigmentation




Genotype
MGI:3690850
ht10
Allelic
Composition		 KitlSl/KitlSl-d
Genetic
Background		 (WC/ReJ KitlSl x B6.D2-KitlSl-d/J)F1-KitlSl/KitlSl-d/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
KitlSl-d mutation (3 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

KitlSl/KitlSl-d mouse

growth/size/body
decreased body weight ( J:111273 )
• male mutants weigh 29, 27, and 13% less than than wild-type littermates at 5, 7, and 12 weeks of age
postnatal growth retardation ( J:111273 )
• at 5 weeks, tibial length in males is less than controls, but by 12 weeks there has been catch-up growth and no significant difference is detected

skeleton
abnormal osteoblast physiology ( J:111273 )
• in culture, primary osteoblasts display decreased mineralization compared to wild-type when both are treated with BMP-2
abnormal osteoclast morphology ( J:111273 )
• osteoclast surface per bone surface is increased from 59% at 5 weeks to 441% at 12 weeks compared to wild-type males
decreased bone mineral content ( J:111273 )
• whole body bone mineral content (BMC) is reduced in males compared to controls at all age groups
• in females, wild-type BMC is higher than in female mutants at 5 weeks
decreased bone mineral density ( J:111273 )
• bone mineral density (BMD) in males is significantly reduced at all age groups compared to controls; whole body as well as long bone and lumbar vertebral BMD are reduced
• in females, BMD at 5 weeks is reduced compared to controls with exception of the femur
• magnitude of change for each bone is larger in male mutants (9-41%) than female mutants (5-25%)
decreased trabecular bone volume ( J:111273 )
• cancellous bone volume/tissue volume is significantly reduced compared to wild-type
decreased compact bone thickness ( J:111273 )
• cortical and marrow area of tibias is reduced in males vs controls
abnormal skeleton development ( J:111273 )
• bone formation rate is decreased in 5 week old mice and to a lesser extent at 7 weeks, but no difference is seen at 12 weeks

hematopoietic system
increased erythrocyte protoporphyrin level ( J:5985 )
• moderate but significant increase in protoporphrin levels in red blood cells compared to controls
abnormal osteoclast morphology ( J:111273 )
• osteoclast surface per bone surface is increased from 59% at 5 weeks to 441% at 12 weeks compared to wild-type males

immune system
abnormal osteoclast morphology ( J:111273 )
• osteoclast surface per bone surface is increased from 59% at 5 weeks to 441% at 12 weeks compared to wild-type males

homeostasis/metabolism
increased erythrocyte protoporphyrin level ( J:5985 )
• moderate but significant increase in protoporphrin levels in red blood cells compared to controls

cellular
abnormal osteoblast physiology ( J:111273 )
• in culture, primary osteoblasts display decreased mineralization compared to wild-type when both are treated with BMP-2




Genotype
MGI:3693198
cx11
Allelic
Composition		 Baxtm1Sjk/Bax+
KitlSl/KitlSl
Tg(Pou5f1-GFP)1Scho/?
Genetic
Background		 involves: 129X1/SvJ * C3H * CD-1 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
KitlSl mutation (3 available); any Kitl mutation (94 available)
Tg(Pou5f1-GFP)1Scho mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal primordial germ cell proliferation ( J:115283 )
• increased apoptosis of primordial germ cells
• decreased germ cell proliferation

cellular
abnormal primordial germ cell proliferation ( J:115283 )
• increased apoptosis of primordial germ cells
• decreased germ cell proliferation




Genotype
MGI:3693197
cx12
Allelic
Composition		 Baxtm1Sjk/Baxtm1Sjk
KitlSl/KitlSl
Tg(Pou5f1-GFP)1Scho/?
Genetic
Background		 involves: 129X1/SvJ * C3H * CD-1 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
KitlSl mutation (3 available); any Kitl mutation (94 available)
Tg(Pou5f1-GFP)1Scho mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal primordial germ cell migration ( J:115283 )
• defective germ cell migration out of the hindgut
abnormal primordial germ cell proliferation ( J:115283 )
• normal apoptosis of primordial germ cells
• decreased germ cell proliferation

cellular
abnormal primordial germ cell migration ( J:115283 )
• defective germ cell migration out of the hindgut
abnormal primordial germ cell proliferation ( J:115283 )
• normal apoptosis of primordial germ cells
• decreased germ cell proliferation




Genotype
MGI:3817636
cx13
Allelic
Composition		 KitlSl/Kitl+
Tg(PGK1-KITLG*220)441Daw/0
Genetic
Background		 involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
Tg(PGK1-KITLG*220)441Daw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:32600 )
• 18% of offspring show more severe pigment loss than either parental strain

hematopoietic system
decreased mast cell number ( J:32600 )
• numbers of connective tissue mast cells are greatly reduced relative to controls

immune system
decreased mast cell number ( J:32600 )
• numbers of connective tissue mast cells are greatly reduced relative to controls

integument
abnormal coat/hair pigmentation ( J:32600 )
• 18% of offspring show more severe pigment loss than either parental strain




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Send questions and comments to User Support. 		last database update
11/12/2024
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