Phenotypes associated with this allele

• Allele Symbol: Kitl^Sl-pan
• Allele Name: steel panda
• Allele ID: MGI:1856167
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kitl^Sl-pan/Kitl^Sl-pan	either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)	MGI:3045105
hm2	Kitl^Sl-pan/Kitl^Sl-pan	involves: C3H	MGI:2662779
ht3	Kitl^Sl-pan/Kitl^+	either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)	MGI:3045104

Genotype
MGI:3045105

hm1

• Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan
• Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

white spotting ( J:23593 )

• white coat with black ears

endocrine/exocrine glands

impaired ovarian folliculogenesis ( J:23593 )

♀ • arrest at the primary follicle stage

reproductive system

reproductive system phenotype ( J:23593 )

N • no defects were observed in the postnatal testes

decreased oocyte number ( J:23593 )

♀ • reduced number of oocytes in the postnatal ovary

decreased primordial germ cell number ( J:23593 )

• progressive decrease in primordial germ cells in both females and males; ~25% that of wild-type controls at E11.5 and ~10% at E12.5

• in spite of the reduced PGC number in males, normal numbers of differentiating germ cells were observed in older males, putatively due to an increase in the mitotic proliferation of spermatogonia

impaired ovarian folliculogenesis ( J:23593 )

♀ • arrest at the primary follicle stage

female infertility ( J:23593 )

♀ • attributable to decreased numbers of oocytes

integument

white spotting ( J:23593 )

• white coat with black ears

cellular

decreased oocyte number ( J:23593 )

♀ • reduced number of oocytes in the postnatal ovary

decreased primordial germ cell number ( J:23593 )

• progressive decrease in primordial germ cells in both females and males; ~25% that of wild-type controls at E11.5 and ~10% at E12.5

• in spite of the reduced PGC number in males, normal numbers of differentiating germ cells were observed in older males, putatively due to an increase in the mitotic proliferation of spermatogonia

Genotype
MGI:2662779

hm2

• Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan
• Genetic Background: involves: C3H

pigmentation

irregular coat pigmentation ( J:4746 )

• homozygotes display pigmented ears and scrotum

• eye color is distinctively black but normal

white spotting ( J:4746 )

• homozygotes are black-eyed whites

hematopoietic system

macrocytic anemia ( J:4746 )

• homozygotes exhibit a mild macrocytic anemia

reproductive system

decreased oocyte number ( J:4746 )

♀ • in newborn homozygotes, the number of oocytes is reduced to 20% of that in heterozygotes

decreased male germ cell number ( J:4746 )

♂ • at P0, the germ cell number in homozygous mutant testes is reduced to 30% of that in heterozygotes

♂ • at P4, the male germ cell number is 50% of that in heterozygotes, suggesting a compensatory proliferation

♂ • by P13, spermatogonia development appears relatively unaffected

decreased primordial germ cell number ( J:4746 )

• at E8-E11, homozygotes display a decreased number of primordial germ cells relative to wild-type controls

impaired ovarian folliculogenesis ( J:4746 )

♀ • in young and adult homozygotes, ovarian follicle development is primarily arrested at the one-layered cuboidal stage

small ovary ( J:4746 )

♀ • neonatal mutant ovaries are significantly smaller than wild-type

female infertility ( J:4746 )

♀ • females, but not males, are sterile

endocrine/exocrine glands

impaired ovarian folliculogenesis ( J:4746 )

♀ • in young and adult homozygotes, ovarian follicle development is primarily arrested at the one-layered cuboidal stage

small ovary ( J:4746 )

♀ • neonatal mutant ovaries are significantly smaller than wild-type

integument

irregular coat pigmentation ( J:4746 )

• homozygotes display pigmented ears and scrotum

• eye color is distinctively black but normal

white spotting ( J:4746 )

• homozygotes are black-eyed whites

cellular

decreased oocyte number ( J:4746 )

♀ • in newborn homozygotes, the number of oocytes is reduced to 20% of that in heterozygotes

decreased male germ cell number ( J:4746 )

♂ • at P0, the germ cell number in homozygous mutant testes is reduced to 30% of that in heterozygotes

♂ • at P4, the male germ cell number is 50% of that in heterozygotes, suggesting a compensatory proliferation

♂ • by P13, spermatogonia development appears relatively unaffected

decreased primordial germ cell number ( J:4746 )

• at E8-E11, homozygotes display a decreased number of primordial germ cells relative to wild-type controls

Genotype
MGI:3045104

ht3

• Allelic Composition: Kitl^Sl-pan/Kitl⁺
• Genetic Background: either: (involves: C3H/HeJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J)

pigmentation

diluted coat color ( J:23593 )

reproductive system

reproductive system phenotype ( J:23593 )

N • both males and females were fertile

decreased primordial germ cell number ( J:23593 )

• the number of primordial germ cells (PGCs) in females was reduced to ~55% that of wild-type females at E11.5

• the number of PGCs in males was reduced to ~45% that of wild-type males at E11.5

integument

diluted coat color ( J:23593 )

cellular

decreased primordial germ cell number ( J:23593 )

• the number of primordial germ cells (PGCs) in females was reduced to ~55% that of wild-type females at E11.5

• the number of PGCs in males was reduced to ~45% that of wild-type males at E11.5