Phenotypes associated with this allele

• Allele Symbol: Glra1^spd-ot
• Allele Name: spasmodic oscillator
• Allele ID: MGI:1856177
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glra1^spd-ot/Glra1^spd-ot	C57BL/6J-Glra1^spd-ot Mpzl3^rc	MGI:3624368
hm2	Glra1^spd-ot/Glra1^spd-ot	involves: C57BL/6J	MGI:3810131
ht3	Glra1^m1Cpai/Glra1^spd-ot	involves: 129 * C57BL/6 * C57BL/6J	MGI:6471175

Genotype
MGI:3624368

hm1

• Allelic Composition: Glra1^spd-ot/Glra1^spd-ot
• Genetic Background: C57BL/6J-Glra1^spd-ot Mpzl3^rc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:13463 )

• usually die about 22-23 days of age

behavior/neurological

tremors ( J:13463 )

• begin to tremble violently and very rapidly at about 14 days of age; severity of tremor increases daily

• at 19-21 days of age, mutants have prolonged periods of great rigor or stiffness; therapy with aminooxyacetic acid is helpful but only temporarily

Genotype
MGI:3810131

hm2

• Allelic Composition: Glra1^spd-ot/Glra1^spd-ot
• Genetic Background: involves: C57BL/6J

mortality/aging

postnatal lethality ( J:107942 )

• homozygotes die by the end of the third week after birth

nervous system

nervous system phenotype ( J:132622 )

N • mice exhibit normal spontaenous glycinergic inhibitory postsynaptic currents in amacrine cells

decreased neuron number ( J:107942 )

• in mutants there is a reduction or absence of post-inspiratory neurons compared to wild-type

abnormal nervous system electrophysiology ( J:107942 )

• phrenic nerve discharge patterns of mutant mice vary with respect to burst frequency and duration of expiration and inspiration compared to wild-type mice; mutants displayed more frequent phrenic nerve discharges with shorter, less regular expiratory intervals

muscle

muscle spasm ( J:107942 )

• after rapid breathing episodes, single or multiple whole-body spasms occur with intervals between spasms of 6 seconds to more than 1 minute

respiratory system

abnormal pulmonary respiratory rate ( J:107942 )

• conscious mutants (P16-23) display disturbed respiratory patterns characterized by periods of slow breathing and intermittent episodes of rapid breathing; episodes are of variable (2-10 sec)

Genotype
MGI:6471175

ht3

• Allelic Composition: Glra1^m1Cpai/Glra1^spd-ot
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

mortality/aging

preweaning lethality, complete penetrance ( J:248717 )

• mice die 4 weeks after birth