All Phenotypes T MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

T
brachyury
MGI:1856184

Summary

31 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	T/T	involves: BTBR	MGI:3663267
hm2	T/T	Not Specified	MGI:2169509
ht3	T/T⁺	Not Specified	MGI:3663264
ht4	T^c/T	Not Specified	MGI:3783797
cx5	Sp5^tm1Rbe/Sp5^tm1Rbe T/T⁺	involves: 129P2/Ola * C57BL/6J	MGI:3029242
cx6	T/T⁺ t^h7m2/t⁺ Itpr3^tf/Itpr3⁺	involves: BTBR	MGI:5465016
cx7	Itpr3^tf/Itpr3⁺ T/T⁺ t^hr4/t⁺	involves: BTBR	MGI:5465159
cx8	T/t^wPas1	involves: BTBR/Nev T * M. m. brevirostris	MGI:4821115
cx9	T/T⁺ Tg(T)118.9Bgh/0	involves: C57BL/6 * CBA	MGI:3784873
cx10	T/t^btm	involves: C57BL/6 * MOL-NIS	MGI:4457262
cx11	T/t^wPas2	involves: M. m. brevirostris	MGI:4821153
cx12	T/t^wPas3	involves: M. m. domesticus	MGI:4821268
cx13	T/t^w73	involves: M. m. musculus	MGI:5288480
cx14	T/t^btm	MOL-NIS	MGI:4819839
cx15	T/t⁴	Not Specified	MGI:4461305
cx16	T t^s6/T⁺ t⁺	Not Specified	MGI:4839335
cx17	T t⁺/T⁺ t^h17	Not Specified	MGI:4844309
cx18	T t⁺/T⁺ t^h45	Not Specified	MGI:4868204
cx19	T t^h20/T⁺ t⁺	Not Specified	MGI:4868366
cx20	T t⁺/T⁺ t^Tu3	Not Specified	MGI:5284985
cx21	T/T⁺ t^h7m/t⁺	Not Specified	MGI:5465011
cx22	T/t^wN27	Not Specified	MGI:4460903
cx23	T/T⁺ t^h7m2/t⁺	Not Specified	MGI:5465018
cx24	T/T⁺ t^hr1/t⁺	Not Specified	MGI:5465026
cx25	T/T⁺ t^hr15/t⁺	Not Specified	MGI:5465028
cx26	T/T⁺ t^hr4/t⁺	Not Specified	MGI:5465155
cx27	T/t^ks1	Not Specified	MGI:4458399
cx28	T/T⁺ t^low2H/t⁺	Not Specified	MGI:5465165
cx29	T/t^w3	Not Specified	MGI:5906043
cx30	T/t⁶	Not Specified	MGI:3663265
cx31	T/t^AE5	Not Specified	MGI:4461426

Allelic Composition	T/T
Genetic Background	involves: BTBR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart looping ( J:52218 )

• exhibit ventrally displaced ventricular loops and a 50% incidence of inverted heart situs

abnormal heart tube morphology ( J:52218 )

• the early heart tube is bilaterally symmetrical, with a distinct grove on both left and right sides, forming a figure-of-eight outline at E8.5

Allelic Composition	T/T
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:13018 )

• die around E11

embryo

caudal body truncation ( J:13018 )

• posterior region of the body is greatly reduced at E10

decreased embryo size ( J:11933 , J:13018 )

• structures posterior to the forelimb buds are not formed (J:11933)

abnormal limb bud morphology ( J:11933 )

abnormal forelimb bud morphology ( J:13018 )

• anterior limb buds are directed dorsad rather than ventrad

absent hindlimb buds ( J:13018 )

• posterior limb buds are absent as the posterior region of the body does not develop

abnormal neural tube morphology ( J:11933 , J:13018 , J:59271 )

• neural tube is slightly irregular at E8.5 and by E9, is markedly irregular in the posterior end; neural tube is more affected in the posterior than anterior end (J:13018)

• exhibit asymmetry of the neural tube in the mid-region at around E9 (J:13018)

• neural tube sends out branches with secondary lumina and often the branch becomes larger than the primary neural tube (J:13018)

• in some embryos, the neural tube lumen is ruptured to the outside and is continuous with the amniotic cavity (J:13018)

• few cases show fusion between the neural tube and the gut in the posterior region (J:13018)

• abnormal folding and kinking of the neural folds at E8 that culminates in ectopic tubular epithelial structures lying ventral to the developing endogenous neural folds (J:59271)

kinked neural tube ( J:59271 )

absent notochord ( J:13018 )

• notochord is absent, except for fragments in early stages

notochord degeneration ( J:11933 )

abnormal primitive streak formation ( J:11933 )

• backward growth does not occur preventing organization of the posterior axis and emergence of the allantoic placental stalk

abnormal somite development ( J:11933 , J:13018 )

• somites appear normal at early stages but at later stages, they are reduced and by E10, somite tissue is almost absent (J:13018)

abnormal placenta development ( J:11933 )

• results in embryonic death at at E10.75

growth/size/body

abnormal head shape ( J:13018 )

• in a few cases, the head region, particularly the mouth, is malformed

decreased embryo size ( J:11933 , J:13018 )

• structures posterior to the forelimb buds are not formed (J:11933)

cardiovascular system

abnormal dorsal aorta morphology ( J:13018 )

• one of the two dorsal arotae is obliterated by a diverticulum from the neural tube

delayed heart development ( J:13018 )

• heart development is sometimes retarded

abnormal pericardial cavity morphology ( J:13018 )

• commonly, the pericardial cavity is enlarged

hemorrhage ( J:13018 )

• E10 homozygotes contain numerous blood-filled sinuses in the posterior end

hemopericardium ( J:13018 )

• pericardial cavity is often filled with blood at E10

craniofacial

abnormal head shape ( J:13018 )

• in a few cases, the head region, particularly the mouth, is malformed

limbs/digits/tail

abnormal limb bud morphology ( J:11933 )

abnormal forelimb bud morphology ( J:13018 )

• anterior limb buds are directed dorsad rather than ventrad

absent hindlimb buds ( J:13018 )

• posterior limb buds are absent as the posterior region of the body does not develop

short tail ( J:13018 )

nervous system

abnormal nervous system development ( J:13018 )

• no regular segmental dorsal ganglia are formed in E10 embryos although ganglion tissue is found

abnormal neural tube morphology ( J:11933 , J:13018 , J:59271 )

• neural tube is slightly irregular at E8.5 and by E9, is markedly irregular in the posterior end; neural tube is more affected in the posterior than anterior end (J:13018)

• exhibit asymmetry of the neural tube in the mid-region at around E9 (J:13018)

• neural tube sends out branches with secondary lumina and often the branch becomes larger than the primary neural tube (J:13018)

• in some embryos, the neural tube lumen is ruptured to the outside and is continuous with the amniotic cavity (J:13018)

• few cases show fusion between the neural tube and the gut in the posterior region (J:13018)

• abnormal folding and kinking of the neural folds at E8 that culminates in ectopic tubular epithelial structures lying ventral to the developing endogenous neural folds (J:59271)

kinked neural tube ( J:59271 )

integument

abnormal epidermal layer morphology ( J:13018 )

• exhibit transient blistering of the dorsal epithelium, first seen at the time of the formation of the first few somites but is completely gone by the time the embryo has attained the second flexure

bleb ( J:13018 )

• embryos exhibit small paired or unpaired blebs or small vesicles on either side of the mid-line at E8.5-9

homeostasis/metabolism

hemopericardium ( J:13018 )

• pericardial cavity is often filled with blood at E10

Allelic Composition	T/T⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased ventral ectodermal ridge size ( J:15081 )

• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size

decreased caudal vertebrae number ( J:15081 )

• caudal vertebrae numbers range from 10 to 24, with an average of 21

short tail ( J:13018 , J:15081 )

• seen by E11 (J:13018)

• tail is reduced by about 1/3 in most mutants (J:15081)

embryo

abnormal neural tube morphology ( J:13018 )

• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal

abnormal notochord morphology ( J:13018 , J:15081 )

• contain a notochord, however it can be retained in the roof of the gut or cloaca for varying distances and for a limited period, it may be slow to separate from the overlying neural plate or neural tube, or it may secondarily become incorporated completely into the neural tube or the tail-gut (J:15081)

• the notocord has a central lumen in places (J:15081)

• commonly see branching of the notochord proper; at E10-12.5, branches occur mainly in the region of the cloaca and the proximal parts of the tail (J:15081)

decreased ventral ectodermal ridge size ( J:15081 )

• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 74% of normal size

skeleton

decreased caudal vertebrae number ( J:15081 )

• caudal vertebrae numbers range from 10 to 24, with an average of 21

decreased presacral vertebrae number ( J:15081 )

nervous system

abnormal neural tube morphology ( J:13018 )

• neural tube is abnormal/misshapen in the ventral part and in cases in which the notochord is abnormal

Allelic Composition	T^c/T
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
T^c mutation (3 available); any T mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:5003 )

• these compound heterozygotes display the same embryonic abnormalities at embryonic day 9 to 10 as T/T homozygotes

Allelic Composition	Sp5^tm1Rbe/Sp5^tm1Rbe T/T⁺
Genetic Background	involves: 129P2/Ola * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp5^tm1Rbe mutation (0 available); any Sp5 mutation (15 available)
T mutation (22 available); any T mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased caudal vertebrae number ( J:65743 )

• majority of tails are comprised of fewer than 8 vertebrae

short tail ( J:65743 )

skeleton

abnormal vertebrae morphology ( J:65743 )

decreased caudal vertebrae number ( J:65743 )

• majority of tails are comprised of fewer than 8 vertebrae

abnormal lumbar vertebrae morphology ( J:65743 )

• lumbar vertebrae defect consisting of an imperfect fusion of the two ventral halves of the vertebra, resulting in an abnormal centrum

Allelic Composition	T/T⁺ t^h7m2/t⁺ Itpr3^tf/Itpr3⁺
Genetic Background	involves: BTBR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr3^tf mutation (20 available); any Itpr3 mutation (176 available)
T mutation (22 available); any T mutation (59 available)
t^h7m2 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:34190 )

N	• mice exhibit normal fertility

Allelic Composition	Itpr3^tf/Itpr3⁺ T/T⁺ t^hr4/t⁺
Genetic Background	involves: BTBR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr3^tf mutation (20 available); any Itpr3 mutation (176 available)
T mutation (22 available); any T mutation (59 available)
t^hr4 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:169366 )

• high transmission ratio distortion in favour of the t^hr4 haplotype from males

Allelic Composition	T/t^wPas1
Genetic Background	involves: BTBR/Nev T * M. m. brevirostris

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^wPas1 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:6461 )

• when males of this genotype are mated to wild-type females the t-haplotype appears among teh offspring more frequently than expected

reproductive system

transmission ratio distortion ( J:6461 )

Allelic Composition	T/T⁺ Tg(T)118.9Bgh/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
Tg(T)118.9Bgh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:3956 )

N	• in the presence of T, transgene carriers have normal length tails, indicative of a complete rescue of phenotype

Allelic Composition	T/t^btm
Genetic Background	involves: C57BL/6 * MOL-NIS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^btm mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal body axis extension ( J:21054 )

• attenuated development of the posterior part of the body

abnormal neural tube morphology ( J:21054 )

• generally distorted, duplicated or fused with the mesenchyme

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

abnormal notochord morphology ( J:21054 )

• E11-12 embryos show abnormalities in the medio-dorsal area

notochord degeneration ( J:21054 )

• seen in E11-12 embryos

split notochord ( J:21054 )

• seen in E11-12 embryos

abnormal tail bud morphology ( J:21054 )

• at E10 a constriction occurs as the tail develops

nervous system

abnormal neural tube morphology ( J:21054 )

• generally distorted, duplicated or fused with the mesenchyme

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

abnormal spinal cord morphology ( J:21054 )

• posterior to the lumbosacral level the cord is severely distorted or duplicated and devoid of vertebrae

limbs/digits/tail

absent caudal vertebrae ( J:21054 )

abnormal tail development ( J:21054 )

abnormal tail bud morphology ( J:21054 )

• at E10 a constriction occurs as the tail develops

absent tail ( J:21054 )

• mice with this genotype lack a tail at birth and have blood listers or red scars on the dorsal skin at the middle of the lumbosacral region

skeleton

meningomyelocele ( J:21054 )

• presents as a dorsal blood blister in the lumbosacral region

absent caudal vertebrae ( J:21054 )

abnormal thoracic vertebrae morphology ( J:21054 )

• rib fusions, lack of vertebral bodies and arches

abnormal lumbar vertebrae morphology ( J:21054 )

• rib fusions, lack of vertebral bodies and arches

absent sacral vertebrae ( J:21054 )

absent vertebral arch ( J:21054 )

• an abnormality of thoracic and lumbar vertebrae

absent vertebral body ( J:21054 )

• an abnormality of thoracic and lumbar vertebrae

absent vertebrae ( J:21054 )

Allelic Composition	T/t^wPas2
Genetic Background	involves: M. m. brevirostris

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^wPas2 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:6461 )

reproductive system

transmission ratio distortion ( J:6461 )

• in a test cross with a wild-type female mouse the t-haplotype is seen in offspring less frequently than expected

Allelic Composition	T/t^wPas3
Genetic Background	involves: M. m. domesticus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^wPas3 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:6461 )

reproductive system

transmission ratio distortion ( J:6461 )

• when males of this genotype are mated to wild-type females the t haplotype occurs among the offspring more frequently than expected

Allelic Composition	T/t^w73
Genetic Background	involves: M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^w73 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:175677 )

• males of this genotype transmit t^w73 to 88.6 per cent of offspring

limbs/digits/tail

absent tail ( J:175677 )

• all mice of this genotype are tailless

Allelic Composition	T/t^btm
Genetic Background	MOL-NIS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^btm mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:14919 )

• all mice are dead by 60 days of age; the few longest-lived have hind-limb paralysis

perinatal lethality, incomplete penetrance ( J:14919 )

• most die shortly after birth and have a blood blister in the lumbosacral area and hind-limb paralysis

limbs/digits/tail

absent tail ( J:14919 )

• all mice of this genotype are tailless

reproductive system

reproductive system phenotype ( J:14919 )

N	• mice are fertile and there is no evidence of transmission ratio distortion

Allelic Composition	T/t⁴
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t⁴ mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal tail morphology ( J:36683 )

absent tail ( J:36683 )

reproductive system

transmission ratio distortion ( J:36683 )

• T-bearing gametes are in excess although not uniformly the case from male to male

Allelic Composition	T t^s6/T⁺ t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^s6 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:6478 )

• 85% of offspring produced from 3 matings of Tt^s6 males to wild-type females are short-tailed; 15% are normal-tailed

Allelic Composition	T t⁺/T⁺ t^h17
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^h17 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:5889 )

• mice with this genotype have short tails; they are not tailless as are mice heterozygous for brachyury and carrying any of the majority of other t haplotypes

• there is no transmission ratio distortion as might be expected from males of this genotype

Allelic Composition	T t⁺/T⁺ t^h45
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^h45 mutation (1 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:7443 )

Allelic Composition	T t^h20/T⁺ t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^h20 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:5889 )

Allelic Composition	T t⁺/T⁺ t^Tu3
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^Tu3 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:6700 )

N	• the tail length is normal although a mouse inheriting a t haplotype with T is frequently tailless

Allelic Composition	T/T⁺ t^h7m/t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^h7m mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:34190 )

Allelic Composition	T/t^wN27
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^wN27 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:32745 )

• indicative of the presence of a t haplotype

Allelic Composition	T/T⁺ t^h7m2/t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^h7m2 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:34190 )

Allelic Composition	T/T⁺ t^hr1/t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^hr1 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:183153 )

Allelic Composition	T/T⁺ t^hr15/t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^hr15 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:192386 )

Allelic Composition	T/T⁺ t^hr4/t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^hr4 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:169366 )

Allelic Composition	T/t^ks1
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^ks1 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:8922 )

reproductive system

transmission ratio distortion ( J:8922 )

• only 37% of sperm from males of this genotype carry the t^ks1 haplotype

Allelic Composition	T/T⁺ t^low2H/t⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^low2H mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:183153 )

N	• no effect on tail length

Allelic Composition	T/t^w3
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^w3 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent tail ( J:23652 )

Allelic Composition	T/t⁶
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t⁶ mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased ventral ectodermal ridge size ( J:15081 )

• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size

embryo

abnormal notochord morphology ( J:15081 )

• the notochord is increased in bulk not only in the distal growth zone (as in T heterozygotes) but in the whole tail, in the cloacal region and even more anteriorly in the lumbar region and has large lumina

• the notochord is present throughout the length of the tail, however it becomes incorporated into the neural tube throughout the tail and often the cloacal region

decreased ventral ectodermal ridge size ( J:15081 )

• the size of the ventral ectodermal ridge of the tail (VER) is reduced to 69% of the normal size

Allelic Composition	T/t^AE5
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^AE5 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal tail morphology ( J:83862 )

absent tail ( J:83862 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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