All Phenotypes Eda<Ta> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eda^Ta
tabby
MGI:1856197

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eda^Ta/Eda^Ta	B6CBACa A^w-J/A-Eda^Ta/J-XO	MGI:2180519
hm2	Eda^Ta/Eda^Ta	B6.Cg-A^w-J Eda^Ta/JGbms	MGI:6200722
hm3	Eda^Ta/Eda^Ta	Not Specified	MGI:3715363
ht4	Eda^Ta/Eda⁺	B6CBACa A^w-J/A-Eda^Ta/J-XO	MGI:3842174
ht5	Eda^Ta/Eda⁺	C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J	MGI:3842172
ht6	Eda^Ta/Eda⁺	involves: A * C57BL * CBA * RIII	MGI:3711696
ht7	Eda^Ta/Eda⁺	Not Specified	MGI:4459465
cx8	Eda^Ta/Y Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}	involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe	MGI:3818300
cx9	Eda^Ta/Eda^Ta Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}	involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe	MGI:3818299
cx10	Eda^Ta/Eda⁺ Edaradd^cr/Edaradd⁺	involves: JU/Fa	MGI:4353024
ot11	Eda^Ta/Y	B6CBACa A^w-J/A-Eda^Ta/J-XO	MGI:3842175
ot12	Eda^Ta/Y	B6.Cg-A^w-J Eda^Ta/JGbms	MGI:6202582
ot13	Eda^Ta/Y	involves: A * C57BL * CBA * RIII	MGI:3711694
ot14	Eda^Ta/Y	Not Specified	MGI:4459458

Allelic Composition	Eda^Ta/Eda^Ta
Genetic Background	B6CBACa A^w-J/A-Eda^Ta/J-XO

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:147677 )

• only 13% of mice exhibit a normal palatal rugae pattern

• 32% of mice exhibit different number of rugae on the left and right side compared to 25% of wild-type mice

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance

• rugae V and VI are most often affected

• mice exhibit fewer ruga VI and VII abnormalities than in heterozygotes

• mice exhibit more ruga V abnormalities than in heterozygotes

• ruga V is less often absent compared to in heterozygotes

• ruga IV is S-shaped more often than in heterozygotes and wild-type mice

digestive/alimentary system

abnormal palatal rugae morphology ( J:147677 )

• only 13% of mice exhibit a normal palatal rugae pattern

• 32% of mice exhibit different number of rugae on the left and right side compared to 25% of wild-type mice

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance

• rugae V and VI are most often affected

• mice exhibit fewer ruga VI and VII abnormalities than in heterozygotes

• mice exhibit more ruga V abnormalities than in heterozygotes

• ruga V is less often absent compared to in heterozygotes

• ruga IV is S-shaped more often than in heterozygotes and wild-type mice

growth/size/body

abnormal palatal rugae morphology ( J:147677 )

• only 13% of mice exhibit a normal palatal rugae pattern

• 32% of mice exhibit different number of rugae on the left and right side compared to 25% of wild-type mice

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance

• rugae V and VI are most often affected

• mice exhibit fewer ruga VI and VII abnormalities than in heterozygotes

• mice exhibit more ruga V abnormalities than in heterozygotes

• ruga V is less often absent compared to in heterozygotes

• ruga IV is S-shaped more often than in heterozygotes and wild-type mice

Allelic Composition	Eda^Ta/Eda^Ta
Genetic Background	B6.Cg-A^w-J Eda^Ta/JGbms

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair follicle development ( J:26506 )

• lack of tylotrich follicles at E14.5, E16 and E17

thin epidermis ( J:26506 )

• at E17

Allelic Composition	Eda^Ta/Eda^Ta
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal nose morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• accumulation of hair in nasal cavities results in "snuffling"

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

endocrine/exocrine glands

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

limbs/digits/tail

hairless tail ( J:249 )

• devoid or nearly devoid of hair

kinked tail ( J:249 )

• usually a few sharp kinks are seen at the tip

pigmentation

abnormal coat/hair pigmentation ( J:249 )

absent hair follicle pheomelanosome pheomelanin ( J:249 )

• absence of agouti-banding on dorsal hair results in a dark stripe in that region

abnormal skin pigmentation ( J:249 )

• noteably delayed

respiratory system

abnormal nose morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• accumulation of hair in nasal cavities results in "snuffling"

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

vision/eye

narrow eye opening ( J:249 )

integument

abnormal coat/ hair morphology ( J:249 )

abnormal coat/hair pigmentation ( J:249 )

absent hair follicle pheomelanosome pheomelanin ( J:249 )

• absence of agouti-banding on dorsal hair results in a dark stripe in that region

abnormal hair growth ( J:249 )

• hair does not develop behind the ears and on the tail

abnormal hair texture ( J:249 )

• due to the absence of guard-hairs and zig-zag hairs

absent guard hair ( J:249 )

absent zigzag hairs ( J:249 )

abnormal hair follicle development ( J:249 )

• E14-17 embryos lack the complement of prominent hair follicles for this age

abnormal vibrissa number ( J:249 )

• the post-orbital vibrissa is absent

• usually there is one rather than two supra-orbital vibrissae

abnormal skin pigmentation ( J:249 )

• noteably delayed

abnormal tail ring morphology ( J:249 )

• devoid or nearly devoid of tail rings

thin skin ( J:249 )

• noted a few days after birth

growth/size/body

abnormal nose morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• accumulation of hair in nasal cavities results in "snuffling"

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

Allelic Composition	Eda^Ta/Eda⁺
Genetic Background	B6CBACa A^w-J/A-Eda^Ta/J-XO

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:147677 )

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance

• rugae V and VI are most often affected

• mice exhibit more ruga VI and VII abnormalities than in homozygotes

• mice exhibit fewer ruga V abnormalities than in homozygotes

• ruga V is more often absent compared to in homozygotes

• ruga IV is S-shaped less often than in homozygotes

digestive/alimentary system

abnormal palatal rugae morphology ( J:147677 )

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance

• rugae V and VI are most often affected

• mice exhibit more ruga VI and VII abnormalities than in homozygotes

• mice exhibit fewer ruga V abnormalities than in homozygotes

• ruga V is more often absent compared to in homozygotes

• ruga IV is S-shaped less often than in homozygotes

growth/size/body

abnormal palatal rugae morphology ( J:147677 )

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance

• rugae V and VI are most often affected

• mice exhibit more ruga VI and VII abnormalities than in homozygotes

• mice exhibit fewer ruga V abnormalities than in homozygotes

• ruga V is more often absent compared to in homozygotes

• ruga IV is S-shaped less often than in homozygotes

Allelic Composition	Eda^Ta/Eda⁺
Genetic Background	C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:147677 )

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance

• rugae V and VI are most often affected

• mice exhibit more ruga VI and VII abnormalities than in homozygotes

• mice exhibit fewer ruga V abnormalities than in homozygotes

• ruga V is more often absent compared to in homozygotes

• ruga IV is S-shaped less often than in homozygotes

digestive/alimentary system

abnormal palatal rugae morphology ( J:147677 )

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance

• rugae V and VI are most often affected

• mice exhibit more ruga VI and VII abnormalities than in homozygotes

• mice exhibit fewer ruga V abnormalities than in homozygotes

• ruga V is more often absent compared to in homozygotes

• ruga IV is S-shaped less often than in homozygotes

growth/size/body

abnormal palatal rugae morphology ( J:147677 )

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, division of rugae, and S-shaped rugae and rugae discoradance

• rugae V and VI are most often affected

• mice exhibit more ruga VI and VII abnormalities than in homozygotes

• mice exhibit fewer ruga V abnormalities than in homozygotes

• ruga V is more often absent compared to in homozygotes

• ruga IV is S-shaped less often than in homozygotes

Allelic Composition	Eda^Ta/Eda⁺
Genetic Background	involves: A * C57BL * CBA * RIII

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanocyte morphology ( J:249 )

transverse fur striping ( J:249 )

integument

abnormal coat/ hair morphology ( J:249 )

abnormal coat appearance ( J:249 )

• mice are mosaic for transverse striping

• on an agouti background, loss of yellow pigment in hair results in black hair in areas of skin containing the mutation

abnormal hair follicle melanocyte morphology ( J:249 )

transverse fur striping ( J:249 )

Allelic Composition	Eda^Ta/Eda⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:249 )

absent hair follicle pheomelanosome pheomelanin ( J:249 )

• Background Sensitivity: restricted loss of agouti hair color contributes to the appearance of transverse markings on an agouti background

irregular coat pigmentation ( J:249 )

• Background Sensitivity: transverse markings are the result of regional loss of phaeomelanin from agouti hairs and absence or significant loss of of zigzag hairs

transverse fur striping ( J:249 )

• Background Sensitivity: this appearance is the result of regional loss of phaeomelanin from agouti hairs and absence of zigzag hairs

integument

abnormal coat/hair pigmentation ( J:249 )

absent hair follicle pheomelanosome pheomelanin ( J:249 )

• Background Sensitivity: restricted loss of agouti hair color contributes to the appearance of transverse markings on an agouti background

irregular coat pigmentation ( J:249 )

• Background Sensitivity: transverse markings are the result of regional loss of phaeomelanin from agouti hairs and absence or significant loss of of zigzag hairs

transverse fur striping ( J:249 )

• Background Sensitivity: this appearance is the result of regional loss of phaeomelanin from agouti hairs and absence of zigzag hairs

abnormal hair texture ( J:249 )

• Background Sensitivity: a result of loss of zigzag type hairs

striated fur ( J:249 )

• Background Sensitivity: transverse black banding characterizes the appearance of this mouse on an agouti background

• Background Sensitivity: on non-agouti or albino background significant regional loss or absence of zigzag hairs alone results in transverse markings

absent zigzag hairs ( J:249 )

• transverse markings are most distinct where this hair type is absent

decreased zigzag hair amount ( J:249 )

• scarce or absent

Allelic Composition	Eda^Ta/Y Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}
Genetic Background	involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)
Tnfrsf19^{Gt(OST294987)Lex} mutation (1 available); any Tnfrsf19 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal tooth morphology ( J:140329 )

• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

• some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

• molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

• some mice exhibit a loss of the third molar

skeleton

abnormal tooth morphology ( J:140329 )

• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

• some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

• molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

• some mice exhibit a loss of the third molar

endocrine/exocrine glands

absent sweat gland ( J:140329 )

• mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

• mice produce no sweat

integument

absent sweat gland ( J:140329 )

• mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

• mice produce no sweat

abnormal coat/ hair morphology ( J:140329 )

• mice possess only awl hairs

absent auchene hairs ( J:140329 )

abnormal awl hair morphology ( J:140329 )

alopecia ( J:140329 )

• mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern

• alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling

delayed hair appearance ( J:140329 )

• compared to in Eda^Ta homozygotes

absent guard hair ( J:140329 )

absent zigzag hairs ( J:140329 )

abnormal hair follicle development ( J:140329 )

• mice lack primary and secondary hair follicles

• at E18, follicle development in the center of the cranium is absent

• however, treatment with Eda-A1 restores secondary hair follicles

growth/size/body

abnormal tooth morphology ( J:140329 )

• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

• some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

• molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

• some mice exhibit a loss of the third molar

Allelic Composition	Eda^Ta/Eda^Ta Tnfrsf19^{Gt(OST294987)Lex}/Tnfrsf19^{Gt(OST294987)Lex}
Genetic Background	involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal tooth morphology ( J:140329 )

• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

• some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

• molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

• some mice exhibit a loss of the third molar

skeleton

abnormal tooth morphology ( J:140329 )

• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

• some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

• molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

• some mice exhibit a loss of the third molar

endocrine/exocrine glands

absent sweat gland ( J:140329 )

• mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

• mice produce no sweat

integument

absent sweat gland ( J:140329 )

• mice produce no sweat and lack sweat glands as in Eda^Ta homozygotes

anhidrosis ( J:140329 )

• mice produce no sweat

abnormal coat/ hair morphology ( J:140329 )

• mice possess only awl hairs

absent auchene hairs ( J:140329 )

abnormal awl hair morphology ( J:140329 )

alopecia ( J:140329 )

• mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern

• alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling

delayed hair appearance ( J:140329 )

• compared to in Eda^Ta homozygotes

absent guard hair ( J:140329 )

absent zigzag hairs ( J:140329 )

abnormal hair follicle development ( J:140329 )

• mice lack primary and secondary hair follicles

• however, treatment with Eda-A1 restores secondary hair follicles

• at E18, follicle development in the center of the cranium is absent

growth/size/body

abnormal tooth morphology ( J:140329 )

• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice

absent incisors ( J:140329 )

• some mice are missing the incisors

abnormal molar cusp morphology ( J:140329 )

• molars exhibit a reduced number of cusps compared to in wild-type mice

decreased molar number ( J:140329 )

• some mice exhibit a loss of the third molar

Allelic Composition	Eda^Ta/Eda⁺ Edaradd^cr/Edaradd⁺
Genetic Background	involves: JU/Fa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edaradd^cr mutation (1 available); any Edaradd mutation (16 available)
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal molar crown morphology ( J:151073 )

• compound heterozygotes have smaller antero-posterior crown diameter in the upper molars and the second and third lower molars and have larger antero-posterior crown diameter in the first lower molar

small molars ( J:151073 )

skeleton

abnormal molar crown morphology ( J:151073 )

small molars ( J:151073 )

growth/size/body

abnormal molar crown morphology ( J:151073 )

small molars ( J:151073 )

Allelic Composition	Eda^Ta/Y
Genetic Background	B6CBACa A^w-J/A-Eda^Ta/J-XO

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:147677 )

• only 13% of mice exhibit a normal palatal rugae pattern

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance

• rugae V and VI are most often affected

digestive/alimentary system

abnormal palatal rugae morphology ( J:147677 )

• only 13% of mice exhibit a normal palatal rugae pattern

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance

• rugae V and VI are most often affected

growth/size/body

abnormal palatal rugae morphology ( J:147677 )

• only 13% of mice exhibit a normal palatal rugae pattern

• mice exhibit abnormalities in the palatal rugae pattern including shortness of rugae, absence of rugae, S-shaped rugae, and rugae discordance

• rugae V and VI are most often affected

Allelic Composition	Eda^Ta/Y
Genetic Background	B6.Cg-A^w-J Eda^Ta/JGbms

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair follicle development ( J:26506 )

• lack of tylotrich follicles at E14.5, E16 and E17

thin epidermis ( J:26506 )

• at E17

Allelic Composition	Eda^Ta/Y
Genetic Background	involves: A * C57BL * CBA * RIII

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:249 )

abnormal eyelid morphology ( J:249 )

absent Meibomian glands ( J:249 )

narrow eye opening ( J:249 )

endocrine/exocrine glands

absent Meibomian glands ( J:249 )

absent eccrine glands ( J:42660 )

• lack palmar and volar sweat glands

anhidrosis ( J:42660 )

• exhibit anhidrosis

respiratory system

abnormal respiratory system morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• unable to keep nasal cavities clear, impairing air flow causing "snuffling"

abnormal respiratory mucosa morphology ( J:119848 )

• male mice lack submucosal glands

pigmentation

abnormal hair follicle pheomelanosome pheomelanin content ( J:249 )

limbs/digits/tail

abnormal autopod morphology ( J:42660 )

• dermal ridges on the paws are absent in all adults; EGF injection postnatally can induce dermal ridge and sweat gland formation

absent eccrine glands ( J:42660 )

• lack palmar and volar sweat glands

abnormal tail tip morphology ( J:249 )

kinked tail ( J:249 , J:12999 )

• usually there are multiple sharp kinks at the tail tip (J:249)

(J:12999)

skeleton

abnormal skeleton morphology ( J:249 )

abnormal incisor morphology ( J:5018 , J:12999 )

(J:5018)

(J:12999)

absent incisors ( J:5018 )

• often absent

short incisors ( J:5018 )

abnormal molar morphology ( J:12999 )

• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones

• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger

abnormal molar cusp morphology ( J:12999 )

• crown of molars shows a simplified cusp pattern

abnormal molar root morphology ( J:12999 )

• molars have 1-2 composite roots instead of the usual three roots

decreased molar number ( J:5018 , J:12999 )

• third molar is often absent (J:5018)

(J:12999)

small molars ( J:5018 )

• molars are usually smaller than normal

abnormal enamel morphology ( J:12999 )

• increase in enamel cover of the incisors

craniofacial

abnormal incisor morphology ( J:5018 , J:12999 )

(J:5018)

(J:12999)

absent incisors ( J:5018 )

• often absent

short incisors ( J:5018 )

abnormal molar morphology ( J:12999 )

• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones

abnormal molar cusp morphology ( J:12999 )

• crown of molars shows a simplified cusp pattern

abnormal molar root morphology ( J:12999 )

• molars have 1-2 composite roots instead of the usual three roots

decreased molar number ( J:5018 , J:12999 )

• third molar is often absent (J:5018)

(J:12999)

small molars ( J:5018 )

• molars are usually smaller than normal

abnormal enamel morphology ( J:12999 )

• increase in enamel cover of the incisors

abnormal nasal cavity morphology ( J:249 )

• unable to keep nasal cavities clear, impairing air flow causing "snuffling"

integument

absent Meibomian glands ( J:249 )

absent eccrine glands ( J:42660 )

• lack palmar and volar sweat glands

anhidrosis ( J:42660 )

• exhibit anhidrosis

abnormal coat/ hair morphology ( J:249 )

abnormal coat appearance ( J:249 )

abnormal hair follicle pheomelanosome pheomelanin content ( J:249 )

abnormal hair growth ( J:249 )

focal hair loss ( J:249 , J:12999 )

• hair does not develop behind the ears or on the tail (J:249)

(J:12999)

abnormal guard hair morphology ( J:249 )

absent guard hair ( J:249 , J:12999 )

(J:249)

(J:12999)

absent zigzag hairs ( J:249 , J:12999 )

(J:249)

(J:12999)

abnormal vibrissa number ( J:249 )

• usually one rather than two supra-orbital vibrissa

absent vibrissae ( J:249 )

• post-orbital sinus follicle and vibrissa are absent

growth/size/body

abnormal incisor morphology ( J:5018 , J:12999 )

(J:5018)

(J:12999)

absent incisors ( J:5018 )

• often absent

short incisors ( J:5018 )

abnormal molar morphology ( J:12999 )

• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones

abnormal molar cusp morphology ( J:12999 )

• crown of molars shows a simplified cusp pattern

abnormal molar root morphology ( J:12999 )

• molars have 1-2 composite roots instead of the usual three roots

decreased molar number ( J:5018 , J:12999 )

• third molar is often absent (J:5018)

(J:12999)

small molars ( J:5018 )

• molars are usually smaller than normal

abnormal enamel morphology ( J:12999 )

• increase in enamel cover of the incisors

abnormal nasal cavity morphology ( J:249 )

• unable to keep nasal cavities clear, impairing air flow causing "snuffling"

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypohidrotic ectodermal dysplasia		DOID:14793		J:42660

Allelic Composition	Eda^Ta/Y
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eda^Ta mutation (4 available); any Eda mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal nose morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• accumulation of hair in nasal cavities results in "snuffling"

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

endocrine/exocrine glands

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

limbs/digits/tail

hairless tail ( J:249 )

• devoid or nearly devoid of hair

kinked tail ( J:249 )

• usually a few sharp kinks are seen at the tip

pigmentation

abnormal coat/hair pigmentation ( J:249 )

absent hair follicle pheomelanosome pheomelanin ( J:249 )

• absence of agouti-banding on dorsal hair results in a dark stripe in that region

abnormal skin pigmentation ( J:249 )

• noteably delayed

respiratory system

abnormal nose morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• accumulation of hair in nasal cavities results in "snuffling"

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

vision/eye

narrow eye opening ( J:249 )

integument

abnormal coat/ hair morphology ( J:249 )

abnormal coat/hair pigmentation ( J:249 )

absent hair follicle pheomelanosome pheomelanin ( J:249 )

• absence of agouti-banding on dorsal hair results in a dark stripe in that region

abnormal hair growth ( J:249 )

• hair does not develop behind the ears and on the tail

abnormal hair texture ( J:249 )

• due to the absence of guard-hairs and zig-zag hairs

absent guard hair ( J:249 )

absent zigzag hairs ( J:249 )

abnormal hair follicle development ( J:249 )

• E14-17 embryos lack the complement of prominent hair follicles for this age

abnormal vibrissa number ( J:249 )

• the post-orbital vibrissa is absent

• usually there is one rather than two supra-orbital vibrissae

abnormal skin pigmentation ( J:249 )

• noteably delayed

abnormal tail ring morphology ( J:249 )

• devoid or nearly devoid of tail rings

thin skin ( J:249 )

• noted a few days after birth

growth/size/body

abnormal nose morphology ( J:249 )

abnormal nasal cavity morphology ( J:249 )

• accumulation of hair in nasal cavities results in "snuffling"

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are completely absent

• however, the Steno's gland (lateral nasal gland 1) and maxillary sinus gland develop normally

abnormal lateral nasal gland morphology ( J:237227 )

• only lateral nasal gland 3 and 8 develop in mutants, while no other ducts of the other lateral nasal glands are found either in the lateral nasal wall or middle conchal lip

• branching of lateral nasal gland 3 is defective at a more rostral location

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypohidrotic ectodermal dysplasia		DOID:14793		J:237227

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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