Phenotypes associated with this allele

• Allele Symbol: tb
• Allele Name: tumbler
• Allele ID: MGI:1856204
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	tb/tb	Not Specified	MGI:3797571

Genotype
MGI:3797571

hm1

• Allelic Composition: tb/tb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:12166 )

• mice exhibit high mortality rates between 3 and 4 weeks of age

reproductive system

absent corpus luteum ( J:12166 )

♀

reduced fertility ( J:12166 )

• mice exhibit reduced reproductivity

immune system

abnormal thymus involution ( J:12166 )

• mice undergo thymus involution

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:13434 )

• while mice can swim, they are unable to hold onto a rope

abnormal locomotor behavior ( J:13434 )

• mice are unable to walk forward and instead move in a crab-like fashion, somersault, fall and jump in order to move forward

endocrine/exocrine glands

absent lactotrophs ( J:12166 )

pituitary gland hyperplasia ( J:12166 )

• pituitary glands exhibit an increase in cellular population density compared to in wild-type pituitaries

absent corpus luteum ( J:12166 )

♀

abnormal thymus involution ( J:12166 )

• mice undergo thymus involution

growth/size/body

postnatal growth retardation ( J:12166 )

hematopoietic system

abnormal thymus involution ( J:12166 )

• mice undergo thymus involution

nervous system

absent lactotrophs ( J:12166 )

pituitary gland hyperplasia ( J:12166 )

• pituitary glands exhibit an increase in cellular population density compared to in wild-type pituitaries