Analysis Tools
nervous system
| N |
• activation threshold and conduction velocity of L5 dorsal root evoked by electrical stimulation of the sciatic nerve are not significantly different from those of wild-type
• the dose-repsonse curves for opioid peptide impact on dorsal root-evokes slow ventral root potential is normal
|
|
• although the capsaicin-sensitive component in C-fiber response is not significantly afffected, homozygotes are less sensitive to inhibition of femoral nerve-evoked slow ventral root potential by tachykinin NK1 receptor agonist GR82334
• femoral nerve-evoked peak amplitudes of dorsal root potentials are smaller than in wild-type controls but are inhibited by GABAa receptor antagonist bucuculline to a similar extent. The slow component of the dorsal root potential is smaller and does not increase with increased pulse width
|
|
• tachykinin receptor antagonist GR82334 is less inhibitory of the femoral nerve-evoked slow verntral root depolarization than in wild-type controls
|
|
• electrical stimulation of dorsal roots at C-fiber strength yileds a slightly smaller amplitude of monosynaptic reflux and integrated area of slow ventral root potential than in wild-type mice
|
|
• electrical stimulation of a dorsal root at C-fiber strength gives slow ventral root potentials and monosynaptic reflexes that are not diminished by a P/Q-type channel blocker but are diminished by an N-type channel blocker indicating an absence of a P/Q-type channel component in the response
|
behavior/neurological
|
• decreased frequency of foot withdrawals in response to a defined mechanical stimulus with calebrated Von Frey hairs
|
|
• enhanced thermal responses are found in paw flick and tail flick assays compared with wild-type and heterozygotes
|
