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Allele Symbol Allele Name Allele ID |
Mcoln3Va-J varitint waddler Jackson MGI:1856231 |
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| Summary |
11 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are almost entirely variegated both ventrally and dorsally
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• homozygotes are almost entirely variegated both ventrally and dorsally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: at backcross generation N6 to C57BL/6J intercrossing heterozygotes yields only 8% homozygous offspring
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice swim and behave normally
(J:5286)
• both sexes are fertile and do not have the abnormal behavior of Mcoln3Va
(J:64107)
• able to swim
(J:64107)
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• mostly white with patches of dilute color
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• mostly white with patches of dilute color
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygotes express a slightly diluted coat color which is less diluted than that of the original veritant waddler heterozygotes
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• heterozygotes express a small white ventral spot
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• at 2 weeks of age heterozygotes respond to 8- and 16-kHz stimuli only at sound pressure levels of 88 dB and 94 dB respectively, no response was found to click or 32 kHz stimuli, and at 3 weeks of age thresholds increased to >100 dB, which, although it is an early and rapidly progressing hearing loss, is a less severe phenotype than in mice heterozygous for the original veritant waddler mutation
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• heterozygotes express a slightly diluted coat color which is less diluted than that of the original veritant waddler heterozygotes
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• heterozygotes express a small white ventral spot
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• behave normally unlike Mcoln3Va
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• a slightly dilute coat color, large irregular belly spots and white feet and tail tips
• not as varicolored as unlike Mcoln3Va
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• mice exhibit a large, irregular belly spot
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• white feet
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• a slightly dilute coat color, large irregular belly spots and white feet and tail tips
• not as varicolored as unlike Mcoln3Va
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• mice exhibit a large, irregular belly spot
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• white feet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 12 compound heterozygotes were produced in 231 progeny from a Va/+ and VaJ/+ cross (over 50 expected) and 4 of these died young
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• mostly white with patches of dilute color like Mcoln3Va-J/Mcoln3Va-J
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• abnormal behavior like Mcoln3Va/Mcoln3+
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• somewhat smaller than the VaJ homozygous mice
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• only one male bred at 10 months of age
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• mostly white with patches of dilute color like Mcoln3Va-J/Mcoln3Va-J
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks of age F2 progeny of a cross to A/J fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks of age F2 progeny of a cross to BALB/cByJ fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks of age F2 progeny of a cross to C3HeB/FeJLe fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks of age F2 progeny of a cross to CZECHII/EiJ fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks of age F2 progeny of a cross to DBA/2J fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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