Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mcoln3Va-J varitint waddler Jackson MGI:1856231 |
||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
11 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygotes are almost entirely variegated both ventrally and dorsally
|
|
• homozygotes are almost entirely variegated both ventrally and dorsally
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: at backcross generation N6 to C57BL/6J intercrossing heterozygotes yields only 8% homozygous offspring
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice swim and behave normally
(J:5286)
• both sexes are fertile and do not have the abnormal behavior of Mcoln3Va
(J:64107)
• able to swim
(J:64107)
|
|
• mostly white with patches of dilute color
|
|
• mostly white with patches of dilute color
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• heterozygotes express a slightly diluted coat color which is less diluted than that of the original veritant waddler heterozygotes
|
|
• heterozygotes express a small white ventral spot
|
|
• at 2 weeks of age heterozygotes respond to 8- and 16-kHz stimuli only at sound pressure levels of 88 dB and 94 dB respectively, no response was found to click or 32 kHz stimuli, and at 3 weeks of age thresholds increased to >100 dB, which, although it is an early and rapidly progressing hearing loss, is a less severe phenotype than in mice heterozygous for the original veritant waddler mutation
|
|
• heterozygotes express a slightly diluted coat color which is less diluted than that of the original veritant waddler heterozygotes
|
|
• heterozygotes express a small white ventral spot
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• behave normally unlike Mcoln3Va
|
|
• a slightly dilute coat color, large irregular belly spots and white feet and tail tips
• not as varicolored as unlike Mcoln3Va
|
|
• mice exhibit a large, irregular belly spot
|
|
• white feet
|
|
• a slightly dilute coat color, large irregular belly spots and white feet and tail tips
• not as varicolored as unlike Mcoln3Va
|
|
• mice exhibit a large, irregular belly spot
|
|
• white feet
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• only 12 compound heterozygotes were produced in 231 progeny from a Va/+ and VaJ/+ cross (over 50 expected) and 4 of these died young
|
|
• mostly white with patches of dilute color like Mcoln3Va-J/Mcoln3Va-J
|
|
• abnormal behavior like Mcoln3Va/Mcoln3+
|
|
• somewhat smaller than the VaJ homozygous mice
|
|
• only one male bred at 10 months of age
|
|
• mostly white with patches of dilute color like Mcoln3Va-J/Mcoln3Va-J
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 12 weeks of age F2 progeny of a cross to A/J fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 12 weeks of age F2 progeny of a cross to BALB/cByJ fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 12 weeks of age F2 progeny of a cross to C3HeB/FeJLe fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 12 weeks of age F2 progeny of a cross to CZECHII/EiJ fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 12 weeks of age F2 progeny of a cross to DBA/2J fail to respond to a 16 kHz stimulus at >100 dB, indicating that there are no background modifiers ameliorating this phenotype
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/17/2024 MGI 6.24 |
|
|
|
||
