All Phenotypes Kit<W> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kit^W
dominant spotting
MGI:1856232

Summary

28 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^W/Kit^W	B6.Cg-Kit^W/J	MGI:5912375
hm2	Kit^W/Kit^W	Not Specified	MGI:2169625
ht3	Kit^W/Kit⁺	FL/1Re-Kit^W/J	MGI:4849374
ht4	Kit^W/Kit⁺	Not Specified	MGI:2175088
ht5	Kit^tm3.1Bsm/Kit^W	involves: 129S1/Sv * C57BL/6	MGI:4358486
ht6	Kit^tm1.1Bsm/Kit^W	involves: 129S1/Sv * C57BL/6	MGI:4358485
ht7	Kit^W-s/Kit^W	involves: BRS	MGI:3813892
ht8	Kit^W/Kit^W-v	involves: C57BL	MGI:2684689
ht9	Kit^W/Kit^W-v	involves: C57BL/6	MGI:5307249
ht10	Kit^W-37J/Kit^W	involves: C57BL/6 * C57BL/6J * WB	MGI:3813819
ht11	Kit^W-42J/Kit^W	involves: C57BL/6 * C57BL/6J * WB	MGI:3813817
ht12	Kit^W-39J/Kit^W	involves: C57BL/6J	MGI:3813694
ht13	Kit^W/Kit^W-v	involves: C57BL/6J	MGI:3771729
ht14	Kit^W/Kit^W-v	involves: C57BL/6 * WB	MGI:2387552
ht15	Kit^W-Jic/Kit^W	involves: C57BL/6 * WB	MGI:3813815
ht16	Kit^W/Kit^W-v	involves: C57BL * C57BL/6 * WB	MGI:3813557
ht17	Kit^W-n/Kit^W	involves: WB	MGI:3813821
ht18	Kit^W/Kit^W-v	Not Specified	MGI:2171276
ht19	Kit^W/Kit^W-v	(WB Kit^W x B6.Cg-Kit^W-v)F1	MGI:5307250
ht20	Kit^W/Kit^W-v	(WB/ReJ x C57BL/6J-Kit^W-v/J)F1-Kit^W/Kit^W-v/J	MGI:3665485
cx21	f/f⁺ Kit^W/Kit⁺	FL/1Re-Kit^W/J	MGI:4849373
cx22	f/f Kit^W/Kit⁺	FL/1Re-Kit^W/J	MGI:4849372
cx23	Il3^tm1Glli/Il3^tm1Glli Kit^W/Kit^W-v	involves: 129S2/SvPas * C57BL/6 * WB	MGI:3586341
cx24	Flt3^tm1Irl/Flt3^tm1Irl Kit^W/Kit^W-v	involves: 129S/SvEv * C57BL/6	MGI:3663023
cx25	Kit^W/Kit^W Tg(PDGFB-EPO)321Zbz/?	involves: C3H * C57BL/6	MGI:3714525
cx26	Kit^W/Kit⁺ Tg(PGK1-KITLG*220)441Daw/0	involves: C3H/HeJ	MGI:3817635
cx27	Fbn1^Tsk/Fbn1⁺ Kit^W/Kit⁺	involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ	MGI:3619906
cx28	Fbn1^Tsk/Fbn1⁺ Kit^W/Kit^W-v	involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ	MGI:3619905

Allelic Composition	Kit^W/Kit^W
Genetic Background	B6.Cg-Kit^W/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:243758 )

• weights are normal at embryonic day 16 but by birth the body weight is retarded behind that of wildtype siblings

hematopoietic system

macrocytic anemia ( J:243758 )

• identified as early as embryonic day 16, the earliest timepoint assessed, and the severity is greatest in W/W homozygotes compared with homozygotes for the viable dominant spotting allele or compound heterozgyotes

mortality/aging

abnormal survival ( J:243758 )

• heterozygous intercrosses produce only 14.5% homozygotes instead of the 25% expected, one sixth of which are born dead or die perinatally and nearly all the remainder die by 3 days of age, without postnatal growth

perinatal lethality, incomplete penetrance ( J:243758 )

prenatal lethality ( J:243758 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
macrocytic anemia		DOID:2361		J:243758

Allelic Composition	Kit^W/Kit^W
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:12955 )

• death is within the first week of birth

hematopoietic system

macrocytic anemia ( J:14978 )

• macrocytic anemia begins at 12 days gestation leading to death within the first week of birth

pigmentation

absent coat pigmentation ( J:12955 )

• white coat color, vividly contrasts with normal black eye color

abnormal eye pigmentation ( J:12955 )

• pigment is restricted to retina

vision/eye

abnormal eye pigmentation ( J:12955 )

• pigment is restricted to retina

integument

absent coat pigmentation ( J:12955 )

• white coat color, vividly contrasts with normal black eye color

Allelic Composition	Kit^W/Kit⁺
Genetic Background	FL/1Re-Kit^W/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

high mean erythrocyte cell number ( J:24610 )

• elevated from birth onward

increased hematocrit ( J:24610 )

• slightly elevated from birth onward

Allelic Composition	Kit^W/Kit⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:12955 )

irregular coat pigmentation ( J:12955 )

• pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting ( J:12955 )

• Background Sensitivity: variable amounts of white spotting

hematopoietic system

hematopoietic system phenotype ( J:14978 )

N	• blood parameters are normal

reproductive system

reproductive system phenotype ( J:14978 )

N	• system is normal

integument

abnormal coat/hair pigmentation ( J:12955 )

irregular coat pigmentation ( J:12955 )

variable body spotting ( J:12955 )

• Background Sensitivity: variable amounts of white spotting

Allelic Composition	Kit^tm3.1Bsm/Kit^W
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm3.1Bsm mutation (0 available); any Kit mutation (181 available)
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal ventral coat pigmentation ( J:90485 )

• ventral depigmentation is enhanced compared to in Kit^W heterozygotes

integument

abnormal ventral coat pigmentation ( J:90485 )

• ventral depigmentation is enhanced compared to in Kit^W heterozygotes

Allelic Composition	Kit^tm1.1Bsm/Kit^W
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1.1Bsm mutation (0 available); any Kit mutation (181 available)
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal ventral coat pigmentation ( J:90485 )

• dorsal depigmentation is worse than in Kit^W heterozygotes

integument

abnormal ventral coat pigmentation ( J:90485 )

• dorsal depigmentation is worse than in Kit^W heterozygotes

Allelic Composition	Kit^W-s/Kit^W
Genetic Background	involves: BRS

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-s mutation (0 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:15330 )

• mice die in utero

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	involves: C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-v mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:4972 )

digestive/alimentary system

abnormal interstitial cell of Cajal morphology ( J:70182 )

• absence of intramuscular interstitial cells of Cajal from the lower esophageal sphincter

abnormal digestive system physiology ( J:70182 )

• the mean resting lower esophageal sphincter pressure is significantly lower

muscle

abnormal muscle physiology ( J:70182 )

• the mean resting lower esophageal sphincter pressure is significantly lower

reproductive system

azoospermia ( J:4972 )

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:178942 )

N	• after 6 weeks of exposure to phorbol myristate acetate (PMA), a 10 to 100 fold increase in mast cells in the normally deficient skin is observed; wild-type mice exhibit a 3-4-fold increase following chronic inflammation

decreased basophil cell number ( J:178942 )

• mice show reduced numbers of splenic basophils

decreased mast cell number ( J:178942 )

• mice have no peritoneal or connective tissue mast cells

hematopoietic system

decreased basophil cell number ( J:178942 )

• mice show reduced numbers of splenic basophils

decreased mast cell number ( J:178942 )

• mice have no peritoneal or connective tissue mast cells

Allelic Composition	Kit^W-37J/Kit^W
Genetic Background	involves: C57BL/6 * C57BL/6J * WB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-37J mutation (2 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

pigmentation

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

integument

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

Allelic Composition	Kit^W-42J/Kit^W
Genetic Background	involves: C57BL/6 * C57BL/6J * WB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-42J mutation (1 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

pigmentation

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

integument

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

Allelic Composition	Kit^W-39J/Kit^W
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-39J mutation (2 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

small testis ( J:6571 )

abnormal spermatogenesis ( J:6571 )

• mice lack spermatogenic activity

infertility ( J:6571 )

endocrine/exocrine glands

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

small testis ( J:6571 )

pigmentation

absent coat pigmentation ( J:6571 )

• mice are black-eyed with white coats

integument

absent coat pigmentation ( J:6571 )

• mice are black-eyed with white coats

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	involves: C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Accumulation of lipids in the liver of Kit^W/Kit^W-v mice

growth/size/body

decreased body weight ( J:243758 )

• weights are normal at embryonic day 16 but by birth the body weight is retarded behind that of wildtype siblings and by 14 days of age the average weight is almost 2 grams less than wildtype siblings

hematopoietic system

macrocytic anemia ( J:243758 )

• identified as early as embryonic day 16, the earliest timepoint assessed, and the severity is slighly less than in W homozygotes and more severe than in W-v homozygotes

mortality/aging

preweaning lethality, incomplete penetrance ( J:243758 )

• only 65% of compound heterozygotes identified at birth survived to 21 days of age

liver/biliary system

hepatic steatosis ( J:125831 )

• seen in P7.5 mutants and adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
macrocytic anemia		DOID:2361		J:243758

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	involves: C57BL/6 * WB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

peptic ulcer ( J:6393 )

• 40% developed prepyloric ulcer, however no duodenal ulcers were found

increased esophageal papilloma incidence ( J:6393 )

• observed papillomas in the lower end of the esophagus but not in the upper two-thirds of the esophagus

neoplasm

increased papilloma incidence ( J:6393 )

• 40% developed forestomach papillomas

increased esophageal papilloma incidence ( J:6393 )

• observed papillomas in the lower end of the esophagus but not in the upper two-thirds of the esophagus

immune system

abnormal response to transplant ( J:6084 )

• after receiving splenocytes from Kitl/Kitl donors, 15 weeks later, mice exhibit significant increase in mast cell numbers in skin, stomach and mesentery

• after receiving skin grafts from Kitl/Kitl donors, no increase in mast cell number in skin is seen, compared to increase observed in reciprocal transplant

Allelic Composition	Kit^W-Jic/Kit^W
Genetic Background	involves: C57BL/6 * WB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-Jic mutation (0 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

pigmentation

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

integument

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	involves: C57BL * C57BL/6 * WB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125964 )

• unlike in wild type mice, all mice treated with ET-1 die by 60 minutes

increased susceptibility to xenobiotic induced morbidity/mortality ( J:125964 )

• all mice die following treatment with S6b unlike wild type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:125964 )

• unlike in wild type mice, all mice treated with ET-1 die by 60 minutes

increased susceptibility to xenobiotic induced morbidity/mortality ( J:125964 )

• all mice die following treatment with S6b unlike wild type mice

Allelic Composition	Kit^W-n/Kit^W
Genetic Background	involves: WB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-n mutation (0 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit no mast cells in the skin

abnormal mast cell physiology ( J:27513 )

• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment

pigmentation

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

integument

absent coat pigmentation ( J:27513 )

• mice are black-eyed with white coats

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:210656 )

• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of sertoli cell tight junction barrier dysfunction

reproductive system

abnormal Sertoli cell morphology ( J:210656 )

• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of sertoli cell tight junction barrier dysfunction

abnormal caput epididymis morphology ( J:290452 )

• impaired initial segment differentiation

epididymis degeneration ( J:335479 )

• degenerating initial segment

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	(WB Kit^W x B6.Cg-Kit^W-v)F1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:197334 )

• following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit increased plasma histamine levels or temporary decrease in rectal temperature unlike wild-type mice

decreased susceptibility to induced arthritis ( J:178942 )

• after receiving i.p. injections of K/BxN mouse serum in an antibody-induced (autoimmune) arthritis model, mice are protected from arthritis, except for mild and transient symptoms

skeleton

decreased susceptibility to induced arthritis ( J:178942 )

• after receiving i.p. injections of K/BxN mouse serum in an antibody-induced (autoimmune) arthritis model, mice are protected from arthritis, except for mild and transient symptoms

homeostasis/metabolism

abnormal circulating histamine level ( J:197334 )

• following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit increased plasma histamine levels unlike wild-type mice

abnormal body temperature ( J:197334 )

• following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit temporary decrease in rectal temperature unlike wild-type mice

Allelic Composition	Kit^W/Kit^W-v
Genetic Background	(WB/ReJ x C57BL/6J-Kit^W-v/J)F1-Kit^W/Kit^W-v/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:113500 )

• significantly higher mortality is exhibited by mutants (88%) by day 21 after induction of anti-glomerular basement membrane glomerulonephritis than wild-type (25%)

cardiovascular system

abnormal response to cardiac infarction ( J:106065 )

• exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt

• wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells

increased myocardial infarct size ( J:106065 )

• 35 days after myocardial infarction show increased percentage of left ventricle infracted

decreased vascular permeability ( J:84660 )

• do not display increased vascular permeability in the dura mater in response to acute restrain stress as is seen in wild-type controls

homeostasis/metabolism

abnormal response to cardiac infarction ( J:106065 )

increased myocardial infarct size ( J:106065 )

• 35 days after myocardial infarction show increased percentage of left ventricle infracted

increased erythrocyte protoporphyrin level ( J:5985 )

• moderate but significant increase in protoporphrin levels in red blood cells compared to controls

abnormal interferon level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma

abnormal interleukin level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes

increased urine protein level ( J:113500 )

• mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)

abnormal response/metabolism to endogenous compounds ( J:123463 )

• mice exhibit reduced adenosine-induced airway responsiveness compared with wild-type mice

immune system

immune system phenotype ( J:125656 )

N	• sensitized mice have a normal early phase reaction (initial phase of bronchoconstriction) after ovalbumin challenge

impaired neutrophil recruitment ( J:123463 )

• mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice

abnormal interferon level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma

abnormal interleukin level ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes

decreased inflammatory response ( J:131785 )

• treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased total bronchoalveolar lavage cell numbers (54%) and eosinophils (75%)

kidney inflammation ( J:113500 )

• more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN

renal/urinary system

increased urine protein level ( J:113500 )

• mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)

kidney inflammation ( J:113500 )

• more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN

abnormal renal glomerulus morphology ( J:113500 )

• in mice there is accumulation of PAS stain-positive material as well as crescent formation in glomeruli, compared to wild-type

glomerular crescent ( J:113500 )

• crescent formation in glomeruli

hematopoietic system

increased erythrocyte protoporphyrin level ( J:5985 )

• moderate but significant increase in protoporphrin levels in red blood cells compared to controls

impaired neutrophil recruitment ( J:123463 )

• mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice

respiratory system

decreased airway responsiveness ( J:123463 )

• mice exhibit reduced adenosine-induced airway responsiveness and neutrophil recruitment compared with wild-type mice

Allelic Composition	f/f⁺ Kit^W/Kit⁺
Genetic Background	FL/1Re-Kit^W/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation (4 available); any f mutation (4 available)
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

white spotting ( J:24610 )

• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively

integument

white spotting ( J:24610 )

• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively

Allelic Composition	f/f Kit^W/Kit⁺
Genetic Background	FL/1Re-Kit^W/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation (4 available); any f mutation (4 available)
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:24610 )

• although slightly reduced in body weight relative to controls this is less severe than in flexed-tail homozygotes wildtype at the Kit locus

hematopoietic system

abnormal erythrocyte cell number ( J:24610 )

• the reduction in erythrocyte cell number at birth is less severe than in flex-tail homozygotes that are wildtype at the Kit locus and by 7 days of age the count is higher than normal and this persists

decreased hematocrit ( J:24610 )

• decreased at birth, but closer to normal values than in flexed-tail homozgyotes that are wildtype at the Kit locus

decreased mean corpuscular volume ( J:24610 )

• from birth onward more severe decrease in erythrocyte volume than in flexed-tail homozygotes wildtype at the Kit locus

pigmentation

white spotting ( J:24610 )

• the amount of white pigmentation is greater than the sum of the white pigmentation of the distinct mutants, with females having an average of 54.7% white on the ventrum and males having an average of 59.7%

integument

white spotting ( J:24610 )

Allelic Composition	Il3^tm1Glli/Il3^tm1Glli Kit^W/Kit^W-v
Genetic Background	involves: 129S2/SvPas * C57BL/6 * WB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il3^tm1Glli mutation (1 available); any Il3 mutation (29 available)
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-v mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to parasitic infection ( J:80500 )

• particularly significant delay in expulsion of parasites - Strongyloides venezuelensis

Allelic Composition	Flt3^tm1Irl/Flt3^tm1Irl Kit^W/Kit^W-v
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3^tm1Irl mutation (4 available); any Flt3 mutation (85 available)
Kit^W mutation (10 available); any Kit mutation (181 available)
Kit^W-v mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:27238 )

• slightly reduced body weight

hematopoietic system

thymus hypoplasia ( J:27238 )

abnormal blood cell morphology/development ( J:27238 )

abnormal common myeloid progenitor cell morphology ( J:27238 )

• absolute numbers of myeloid progenitors reduced 8 fold

abnormal myelopoiesis ( J:27238 )

• myeloid lineages are reduced in numbers

decreased bone marrow cell number ( J:27238 )

• reduced cellularity

abnormal leukocyte morphology ( J:27238 )

decreased pro-B cell number ( J:27238 )

• greater reduction in numbers

abnormal T cell number ( J:27238 )

• proportion of CD4 and CD8 single positive T cells is increased 2 fold

• absolute numbers of single positive cells reduced 4 fold

decreased double-negative T cell number ( J:27238 )

• severely restricted in numbers

decreased double-positive T cell number ( J:27238 )

• severely restricted in numbers

decreased lymphocyte cell number ( J:27238 )

• lymphoid lineages are reduced in numbers

decreased B cell number ( J:27238 )

• 10% reduction

• absolute numbers reduced 16%

decreased pre-B cell number ( J:27238 )

• greater reduction

immune system

thymus hypoplasia ( J:27238 )

abnormal myelopoiesis ( J:27238 )

• myeloid lineages are reduced in numbers

abnormal leukocyte morphology ( J:27238 )

decreased pro-B cell number ( J:27238 )

• greater reduction in numbers

abnormal T cell number ( J:27238 )

• proportion of CD4 and CD8 single positive T cells is increased 2 fold

• absolute numbers of single positive cells reduced 4 fold

decreased double-negative T cell number ( J:27238 )

• severely restricted in numbers

decreased double-positive T cell number ( J:27238 )

• severely restricted in numbers

decreased lymphocyte cell number ( J:27238 )

• lymphoid lineages are reduced in numbers

decreased B cell number ( J:27238 )

• 10% reduction

• absolute numbers reduced 16%

decreased pre-B cell number ( J:27238 )

• greater reduction

endocrine/exocrine glands

thymus hypoplasia ( J:27238 )

Allelic Composition	Kit^W/Kit^W Tg(PDGFB-EPO)321Zbz/?
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Tg(PDGFB-EPO)321Zbz mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:79128 )

• thymic TN-1 cells are lacking

abnormal B cell differentiation ( J:79128 )

• severe block to T cell and B cell development is similar to that seen in Kit^W-vkd homozygotes

abnormal T cell differentiation ( J:79128 )

• severe block to T cell and B cell development is similar to that seen in Kit^W-vkd homozygotes

decreased B cell number ( J:79128 )

• bone marrow fraction B cells are lacking

immune system

decreased thymocyte number ( J:79128 )

• thymic TN-1 cells are lacking

abnormal B cell differentiation ( J:79128 )

• severe block to T cell and B cell development is similar to that seen in Kit^W-vkd homozygotes

abnormal T cell differentiation ( J:79128 )

• severe block to T cell and B cell development is similar to that seen in Kit^W-vkd homozygotes

decreased B cell number ( J:79128 )

• bone marrow fraction B cells are lacking

endocrine/exocrine glands

decreased thymocyte number ( J:79128 )

• thymic TN-1 cells are lacking

Allelic Composition	Kit^W/Kit⁺ Tg(PGK1-KITLG*220)441Daw/0
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W mutation (10 available); any Kit mutation (181 available)
Tg(PGK1-KITLG*220)441Daw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:32600 )

• 46% of mice show coat color similar to hemizygous transgenics or heterozygous Kit^W animals, while 29% show wild-type agouti coat coloring

• 25% of double mutants have a more severe deficiency in coat color pigmentation with large areas of hypopigmentation

hypopigmentation ( J:32600 )

hematopoietic system

decreased mast cell number ( J:32600 )

• numbers of connective tissue mast cells are greatly reduced relative to controls

immune system

decreased mast cell number ( J:32600 )

• numbers of connective tissue mast cells are greatly reduced relative to controls

integument

abnormal coat/hair pigmentation ( J:32600 )

• 46% of mice show coat color similar to hemizygous transgenics or heterozygous Kit^W animals, while 29% show wild-type agouti coat coloring

• 25% of double mutants have a more severe deficiency in coat color pigmentation with large areas of hypopigmentation

Allelic Composition	Fbn1^Tsk/Fbn1⁺ Kit^W/Kit⁺
Genetic Background	involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1^Tsk mutation (2 available); any Fbn1 mutation (172 available)
Kit^W mutation (10 available); any Kit mutation (181 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

variable body spotting ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

integument

diluted coat color ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

variable body spotting ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

tight skin ( J:24076 )

skin fibrosis ( J:24076 )

• progressive development of skin fibrosis similar to that seen in single heterozygous Fbn1 mutant mice

Allelic Composition	Fbn1^Tsk/Fbn1⁺ Kit^W/Kit^W-v
Genetic Background	involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:24076 )

absent mast cells ( J:24076 )

• absence of interscapular skin mast cells

respiratory system

overexpanded pulmonary alveolus ( J:24076 )

• enlargement of airspaces

immune system

absent mast cells ( J:24076 )

• absence of interscapular skin mast cells

pigmentation

absent coat pigmentation ( J:24076 )

• white coat and black eyes

integument

absent coat pigmentation ( J:24076 )

• white coat and black eyes

abnormal hypodermis morphology ( J:24076 )

• increase in subcutaneous connective tissue, with an accumulation beneath the panniculus carnosus muscle

tight skin ( J:24076 )

• tight skin develops around 7 days of age

skin fibrosis ( J:24076 )

• develop skin fibrosis, indicating that fibrosis is mast cell independent, however the degree of fibrosis development at older ages (5-7 months) is less than in single heterozygous Fbn1 mutant mice, which contain elevated levels of mast cells, indicating that mast cells contribute to fibrosis later in life

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