All Phenotypes Kit<W-19H> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kit^W-19H
dominant spotting 19 Harwell
MGI:1856233

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^W-19H/Kit^W-19H	involves: 101/H * C3H/HeH	MGI:3036838
ht2	Kit^W-19H/Kit⁺	B6.Cg-Kit^W-19H/EiJ	MGI:3778825
ht3	Kit^W-19H/Kit⁺	involves: 101/H * C3H/HeH	MGI:3036839
cx4	Kit^W-19H/Kit⁺ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778792

Allelic Composition	Kit^W-19H/Kit^W-19H
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-19H mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:7681 )

• die prior to implantation

Allelic Composition	Kit^W-19H/Kit⁺
Genetic Background	B6.Cg-Kit^W-19H/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-19H mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:133405 )

N	• ovaries function and transplant fine

constricted vagina orifice ( J:133405 )

• Background Sensitivity: approximately 60% of females have clsoed vaginas

Allelic Composition	Kit^W-19H/Kit⁺
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-19H mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:7681 )

• some are runted and die before weaning age of unknown causes

pigmentation

variable body spotting ( J:7681 )

• white spotting on feet, tail and belly; spotting elsewhere is possible but infrequent

growth/size/body

postnatal growth retardation ( J:7681 )

• some are small and runted

integument

variable body spotting ( J:7681 )

• white spotting on feet, tail and belly; spotting elsewhere is possible but infrequent

Allelic Composition	Kit^W-19H/Kit⁺ X/Sry^AKR/J
Genetic Background	involves: AKR/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-19H mutation (1 available); any Kit mutation (182 available)
Sry^AKR/J mutation (6 available); any Sry mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small testis ( J:133266 )

sex reversal ( J:133266 )

• Background Sensitivity: hermaphroditism is found within two generations of backcrossing to C57BL/6 and by the third generation completely sex reversed, sterile XY females are found; the frequency of this sex reversal increases with further backcrossing to C57BL/6

endocrine/exocrine glands

small testis ( J:133266 )

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