All Phenotypes Kit<W-41J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kit^W-41J
dominant spotting 41 Jackson
MGI:1856244

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^W-41J/Kit^W-41J	C57BL/6J-Kit^W-41J/J	MGI:3813680
ht2	Kit^W-41J/Kit⁺	C57BL/6J-Kit^W-41J/J	MGI:3813681
ht3	Kit^W-41J/Kit^W-44J	involves: C3H/HeJ * C57BL/6J	MGI:3813685
ht4	Kit^W-39J/Kit^W-41J	involves: C57BL/6J	MGI:3813684
cx5	Gusb^mps/Gusb^mps Kit^W-41J/Kit^W-41J	B6(C)-Kit^W-41J Gusb^mps/BrkJ	MGI:3842194

Allelic Composition	Kit^W-41J/Kit^W-41J
Genetic Background	C57BL/6J-Kit^W-41J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-41J mutation (4 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:6571 )

N	• mice are fertile

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

hematopoietic system

macrocytic anemia ( J:6571 )

• mild, normochromic, macrocytic anemia

endocrine/exocrine glands

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

pigmentation

irregular coat pigmentation ( J:6571 )

• mice exhibit a black-flecked white coat in which the dorsal coat has concentrated areas of black about the head and hind quarters and the ventral coat is white with black hair along lateral borders

integument

irregular coat pigmentation ( J:6571 )

Allelic Composition	Kit^W-41J/Kit⁺
Genetic Background	C57BL/6J-Kit^W-41J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-41J mutation (4 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

macrocytic anemia ( J:6571 )

• mild, normochromic, macrocytic anemia

pigmentation

diluted coat color ( J:6571 )

• mice exhibit slight dilution of their dorsal and ventral coats

belly spot ( J:6571 )

• mice exhibit small white belly spots

integument

diluted coat color ( J:6571 )

• mice exhibit slight dilution of their dorsal and ventral coats

belly spot ( J:6571 )

• mice exhibit small white belly spots

Allelic Composition	Kit^W-41J/Kit^W-44J
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-41J mutation (4 available); any Kit mutation (182 available)
Kit^W-44J mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:6571 )

N	• mice are fertile

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

endocrine/exocrine glands

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

Allelic Composition	Kit^W-39J/Kit^W-41J
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-39J mutation (2 available); any Kit mutation (182 available)
Kit^W-41J mutation (4 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:6571 )

• fewer than expected mice are born alive

reproductive system

reproductive system phenotype ( J:6571 )

N	• mice are fertile

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

endocrine/exocrine glands

abnormal ovarian follicle number ( J:6571 )

• ovaries contain fewer developing follicles than in wild-type mice

small ovary ( J:6571 )

pigmentation

absent coat pigmentation ( J:6571 )

• mice are black-eyed with white coats and have fully pigmented ear pinnae

integument

absent coat pigmentation ( J:6571 )

• mice are black-eyed with white coats and have fully pigmented ear pinnae

Allelic Composition	Gusb^mps/Gusb^mps Kit^W-41J/Kit^W-41J
Genetic Background	B6(C)-Kit^W-41J Gusb^mps/BrkJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gusb^mps mutation (8 available); any Gusb mutation (44 available)
Kit^W-41J mutation (4 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:58272 )

• average life span is approximately 26 weeks

hematopoietic system

decreased hematopoietic stem cell number ( J:58272 )

• severe deficiency of hematopoietic stem cells

cellular

abnormal lysosome morphology ( J:58272 )

• extensive lysosomal storage, evident histologically as large cleared foamy cells, in the liver, kidney, and spleen

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