Analysis Tools|
Allele Symbol Allele Name Allele ID |
KitW-42J dominant spotting 42 Jackson MGI:1856245 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die late in gestation or immediately after birth
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• at E12.5, sub-Mendelian ratios are recovered
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| N |
• testes differentiation is not delayed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
KitW-42J/Kit+
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• mild, normochromic, macrocytic anemia
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• white coat with some dark pigmentation on the ears
• sporadic incidence of patches of pigmented hair around ears and eyes or rump
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• mosaicism for large, sharply defined pigmented area
• attributed to heterogeneity for wild-type allele
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• white coat with some dark pigmentation on the ears
• sporadic incidence of patches of pigmented hair around ears and eyes or rump
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• mosaicism for large, sharply defined pigmented area
• attributed to heterogeneity for wild-type allele
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| N |
• testes differentiation is not delayed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit fewer mast cells in the skin than wild-type mice
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• mice exhibit fewer mast cells in the skin than wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit no mast cells in the skin
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• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment
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• mice are black-eyed with white coats
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• mice exhibit no mast cells in the skin
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• mast cells do not survive co-culture with fibroblast cells and exhibit impaired attachment
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• mice are black-eyed with white coats
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are born alive
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• ovaries contain fewer developing follicles than in wild-type mice
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• mice lack spermatogenic activity
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• ovaries contain fewer developing follicles than in wild-type mice
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• mice are black-eyed with white coats
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• mice are black-eyed with white coats
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die in utero
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• 1 male with bilateral testes was born that had minor internal genitalia abnormalities including: right testis is smaller than left, right epididymis' cauda was not completely formed and the average length of the testes was smaller relative to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males have right testis smaller than the left, especially when the alleles are inherited from the mother
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• one hermaphrodite was found with a left testicular gonad and a contralateral putative ovotestis that was associated with both Mullerian and Wolffian duct derivatives
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• males have right testis smaller than the left, especially when the alleles are inherited from the mother
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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