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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
KitW-e
extreme dominant spotting
MGI:1856260
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
KitW-e/KitW-e involves: 101 * C3H MGI:3721389
hm2
KitW-e/KitW-e involves: 101/H * C3H/HeH MGI:2178297
ht3
KitW-e/Kit+ involves: 101/H * C3H/HeH MGI:3843928
cx4
KitW-e/Kit+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3778814


Genotype
MGI:3721389
hm1
Allelic
Composition
KitW-e/KitW-e
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-e mutation (2 available); any Kit mutation (182 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at all embryonic stages, germ cells tend to adhere together in clumps often at ectopic sites like the vitelline artery, while germ cells in heterozygotes and wild-type embryos are evenly distributed throughout the supporting somatic tissue
• 9% of germ cells remain in the allantois at 9.5 days post coitum (dpc), while 22% are ectopic, in the vitelline artery or the mesenchyme surrounding it while in heterozygotes, only 1% remain in the allantois and 99% are found in the wall of the hindgut
• at 9.5 dpc, germ cells remain confined to the ventral half of the gut, whereas in heterozygotes and wild-type embryos, germ cells become distributed around entire circumference of the hindgut
• at 10.5 dpc, 39% of germ cells remain in the hindgut endothelium and none are found in the genital ridge, compared to heterozygotes and wild-type embryos where ~90% of germ cells have reached the genital ridge and only 10% remain in the hindgut
• migration of germ cells appears to be delayed at later stages of development (10.5 dpc), but is comparable to controls between 8.5 and 9.5 dpc
• between 8.5 and 10.5 days post coitum (dpc), primordial germ cell numbers do not increase significantly, and remain at less than 100 compared to >725 in heterozygotes and wild-type embryos

cellular
• at all embryonic stages, germ cells tend to adhere together in clumps often at ectopic sites like the vitelline artery, while germ cells in heterozygotes and wild-type embryos are evenly distributed throughout the supporting somatic tissue
• 9% of germ cells remain in the allantois at 9.5 days post coitum (dpc), while 22% are ectopic, in the vitelline artery or the mesenchyme surrounding it while in heterozygotes, only 1% remain in the allantois and 99% are found in the wall of the hindgut
• at 9.5 dpc, germ cells remain confined to the ventral half of the gut, whereas in heterozygotes and wild-type embryos, germ cells become distributed around entire circumference of the hindgut
• at 10.5 dpc, 39% of germ cells remain in the hindgut endothelium and none are found in the genital ridge, compared to heterozygotes and wild-type embryos where ~90% of germ cells have reached the genital ridge and only 10% remain in the hindgut
• migration of germ cells appears to be delayed at later stages of development (10.5 dpc), but is comparable to controls between 8.5 and 9.5 dpc
• between 8.5 and 10.5 days post coitum (dpc), primordial germ cell numbers do not increase significantly, and remain at less than 100 compared to >725 in heterozygotes and wild-type embryos




Genotype
MGI:2178297
hm2
Allelic
Composition
KitW-e/KitW-e
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-e mutation (2 available); any Kit mutation (182 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death by 10 days of age is due to anemia
• mice heterozygous for this allele and Kitv are viable but infertile

hematopoietic system

pigmentation
• although the coat is depigmented, eye color is unaffected and appears normal, black

integument
• although the coat is depigmented, eye color is unaffected and appears normal, black




Genotype
MGI:3843928
ht3
Allelic
Composition
KitW-e/Kit+
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-e mutation (2 available); any Kit mutation (182 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• extensive white markings on head, back, and belly

integument
• extensive white markings on head, back, and belly




Genotype
MGI:3778814
cx4
Allelic
Composition
KitW-e/Kit+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-e mutation (2 available); any Kit mutation (182 available)
SryAKR/J mutation (6 available); any Sry mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory