Phenotypes associated with this allele

• Allele Symbol: Kit^W-f
• Allele Name: fertile dominant spotting
• Allele ID: MGI:1856261
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^W-f/Kit^W-f	involves: C3H/HePas	MGI:3055552
ht2	Kit^W-f/Kit^+	involves: C3H/HePas	MGI:3055548

Genotype
MGI:3055552

hm1

• Allelic Composition: Kit^W-f/Kit^W-f
• Genetic Background: involves: C3H/HePas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:6187 )

• some loss by 2 weeks of age due to chronic macrocytic anemia

pigmentation

diluted coat color ( J:6187 , J:27513 )

• typical dilution of pigmented areas not observed (J:6187)

irregular coat pigmentation ( J:6187 )

• extensive depigmented areas lacking a defined pattern

white spotting ( J:27513 )

hematopoietic system

macrocytic anemia ( J:6187 )

decreased erythrocyte cell number ( J:27513 )

decreased mast cell number ( J:27513 )

• mice exhibit slightly fewer mast cells in the skin than wild-type mice

immune system

decreased mast cell number ( J:27513 )

• mice exhibit slightly fewer mast cells in the skin than wild-type mice

reproductive system

reproductive system phenotype ( J:6187 )

N • unlike other homozygous dominant Kit mutations, homozygous mice for this allele are fertile

integument

diluted coat color ( J:6187 , J:27513 )

• typical dilution of pigmented areas not observed (J:6187)

irregular coat pigmentation ( J:6187 )

• extensive depigmented areas lacking a defined pattern

white spotting ( J:27513 )

Genotype
MGI:3055548

ht2

• Allelic Composition: Kit^W-f/Kit⁺
• Genetic Background: involves: C3H/HePas

pigmentation

diluted coat color ( J:27513 )

• typical dilution of pigmented areas not observed on strain of origin but is noted on C57BL/6 background

belly spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

head spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

non-pigmented tail tip ( J:6187 )

hematopoietic system

macrocytic anemia ( J:6187 )

limbs/digits/tail

non-pigmented tail tip ( J:6187 )

integument

diluted coat color ( J:27513 )

• typical dilution of pigmented areas not observed on strain of origin but is noted on C57BL/6 background

belly spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

head spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

non-pigmented tail tip ( J:6187 )