All Phenotypes Tgm3<we> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tgm3^we
wellhaarig
MGI:1856269

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgm3^we/Tgm3^we	Not Specified	MGI:3843783
ht2	Tgm3^we/Tgm3^we-Bkr	involves: 129 * C57BL/10 * UW	MGI:5311631
ht3	Tgm3^we/Tgm3^we-3J	involves: 129P3/J * C57BL/10 * NZB/BlNJ * UW	MGI:5311927
cx4	Bloc1s6^pa/Bloc1s6^pa Tgm3^we/Tgm3^we-Bkr	involves: 129 * C57BL/10 * UW	MGI:5311432

Allelic Composition	Tgm3^we/Tgm3^we
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm3^we mutation (6 available); any Tgm3 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

waved hair ( J:208 )

• the coat comes in very wavy, the wave most apparent between 10 and 21 days of age, then the wave decreases with age

thin hair shaft ( J:208 )

• smaller average diameter hair shaft than normal

curly vibrissae ( J:208 )

• curly whiskers are evident shortly after birth

Allelic Composition	Tgm3^we/Tgm3^we-Bkr
Genetic Background	involves: 129 * C57BL/10 * UW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm3^we mutation (6 available); any Tgm3 mutation (55 available)
Tgm3^we-Bkr mutation (1 available); any Tgm3 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

waved hair ( J:8296 )

Allelic Composition	Tgm3^we/Tgm3^we-3J
Genetic Background	involves: 129P3/J * C57BL/10 * NZB/BlNJ * UW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm3^we mutation (6 available); any Tgm3 mutation (55 available)
Tgm3^we-3J mutation (0 available); any Tgm3 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

waved hair ( J:30778 )

Allelic Composition	Bloc1s6^pa/Bloc1s6^pa Tgm3^we/Tgm3^we-Bkr
Genetic Background	involves: 129 * C57BL/10 * UW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bloc1s6^pa mutation (6 available); any Bloc1s6 mutation (25 available)
Tgm3^we mutation (6 available); any Tgm3 mutation (55 available)
Tgm3^we-Bkr mutation (1 available); any Tgm3 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat appearance ( J:8296 )

• thoracic cavity is unusually small

waved hair ( J:8296 )

skeleton

short femur ( J:8296 )

abnormal thoracic cage shape ( J:8296 )

abnormal vertebral column morphology ( J:8296 )

lordosis ( J:8296 )

• severe curvature abnormality of the cervical and upper thoracic spine

abnormal skeleton development ( J:8296 )

• there is abnormal growth of the linear, endochondral, and radial bones

abnormal skeleton physiology ( J:8296 )

• skeletons are incompletely ossified

behavior/neurological

abnormal gait ( J:8296 )

• mice move with a waddling gait, unable to lift the quarters off the ground

limbs/digits/tail

short femur ( J:8296 )

respiratory system

small lung ( J:8296 )

atelectasis ( J:8296 )

• small lung size is a contributing factor

mortality/aging

lethality, complete penetrance ( J:8296 )

• this genotype dies between 2 and 4 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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