All Phenotypes Gli3<Xt-J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli3^Xt-J
extra toes Jackson
MGI:1856276

Summary

47 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli3^Xt-J/Gli3^Xt-J	B6.C3-Gli3^Xt-J/J	MGI:3629787
hm2	Gli3^Xt-J/Gli3^Xt-J	involves: 129/Sv * C3H/HeJ * C57BL/6	MGI:3711906
hm3	Gli3^Xt-J/Gli3^Xt-J	involves: 129/Sv * C3H/HeJ * C57BL/6J	MGI:3711880
hm4	Gli3^Xt-J/Gli3^Xt-J	involves: C3H * CD-1	MGI:2166944
hm5	Gli3^Xt-J/Gli3^Xt-J	involves: C3H/HeJ	MGI:2176902
hm6	Gli3^Xt-J/Gli3^Xt-J	involves: C3H/HeJ * C57BL/6	MGI:3618223
hm7	Gli3^Xt-J/Gli3^Xt-J	involves: C3H/HeJ * CD-1	MGI:4357964
hm8	Gli3^Xt-J/Gli3^Xt-J	involves: C3H/HeJ * NMRI	MGI:5425259
ht9	Gli3^Xt-J/Gli3⁺	C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J	MGI:3707687
ht10	Gli3^Xt-J/Gli3⁺	involves: 129/Sv * C3H/HeJ * C57BL/6	MGI:3711904
ht11	Gli3^Xt-J/Gli3⁺	involves: C3H * CD-1	MGI:3614408
ht12	Gli3^Xt-J/Gli3⁺	involves: C3H/HeJ	MGI:5562305
ht13	Gli3^Xt-J/Gli3⁺	involves: C3H/HeJ * C57BL/6J * C57BL/6NHsd	MGI:3811811
ht14	Gli3^tm1Blnw/Gli3^Xt-J	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6	MGI:3700186
ht15	Gli3^tm1.2Zllr/Gli3^Xt-J	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI	MGI:5425260
ht16	Gli3^Mos1/Gli3^Xt-J	involves: BALB/cJ * C3H/HeJ * C57BL/6J	MGI:3797118
cn17	Gli3^Xt-J/Gli3^Xt-J Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0	involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL	MGI:4453963
cn18	Gli3^Xt-J/Gli3^Xt-J Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc Tg(Col2a1-cre)3Amc/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	MGI:4414675
cn19	Gli3^Xt-J/Gli3⁺ Spop^{tm1c(KOMP)Mbp}/Spop^{tm1c(KOMP)Mbp} Tg(Prrx1-cre)1Cjt/0	involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J	MGI:5896743
cx20	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺ Gli3^Xt-J/Gli3⁺	either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)	MGI:3846354
cx21	Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt-J/Gli3⁺	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	MGI:2678685
cx22	Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt-J/Gli3^Xt-J	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	MGI:2176890
cx23	Gli2^tm1Alj/Gli2⁺ Gli3^Xt-J/Gli3⁺	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	MGI:3614416
cx24	Gli2^tm1Alj/Gli2⁺ Gli3^Xt-J/Gli3^Xt-J	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1	MGI:3614413
cx25	Gli3^Xt-J/Gli3⁺ Sox10^tm1Weg/Sox10⁺	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	MGI:3797123
cx26	Gli3^Xt-J/Gli3^Xt-J Ihh^tm1Amc/Ihh^tm1Amc	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ	MGI:4414676
cx27	Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt-J/Gli3^Xt-J	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster	MGI:3052545
cx28	Gli1^tm1Alj/Gli1^tm1Alj Gli3^Xt-J/Gli3⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3614422
cx29	Bmp4^tm1Blh/Bmp4⁺ Gli3^Xt-J/Gli3⁺	involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd	MGI:3811812
cx30	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj Gli3^Xt-J/Gli3⁺	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795687
cx31	Gli2^tm2.1Alj/Gli2⁺ Gli3^Xt-J/Gli3^Xt-J	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795690
cx32	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3⁺	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795688
cx33	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3^Xt-J	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795689
cx34	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3⁺	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N	MGI:6113537
cx35	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3^Xt-J	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N	MGI:6113536
cx36	Gas1^tm2Fan/Gas1^tm2Fan Gli3^Xt-J/Gli3^Xt-J	involves: 129/Sv * C3H/HeJ * C57BL/6J	MGI:3711879
cx37	Gli3^Xt-J/Gli3⁺ Rr26^tm1Svok/Rr26^tm1Svok	involves: 129X1/SvJ * C3H/HeJ	MGI:5562303
cx38	Gli3^Xt-J/Gli3⁺ Rr26^tm1Svok/Rr26⁺	involves: 129X1/SvJ * C3H/HeJ	MGI:5562304
cx39	Gli3^Xt-J/Gli3^Xt-J Ski^tm1Cco/Ski⁺	involves: C3H * C57BL/6	MGI:2653485
cx40	Gli3^Xt-J/Gli3^Xt-J Tbx15^de-H/Tbx15^de-H	involves: C3H * C57BL/6J	MGI:3769575
cx41	Gli3^Xt-J/Gli3^Xt-J Tbx15^de-H/Tbx15⁺	involves: C3H * C57BL/6J	MGI:3769576
cx42	Gli3^Xt-J/Gli3^Xt-J Tulp3^hhkr/Tulp3⁺	involves: C3H/HeH * C3H/HeJ * C57BL/6	MGI:3842146
cx43	Gli3^Xt-J/Gli3⁺ Tulp3^hhkr/Tulp3^hhkr	involves: C3H/HeH * C3H/HeJ * C57BL/6	MGI:3842145
cx44	Gli3^Xt-J/Gli3^Xt-J Tulp3^hhkr/Tulp3^hhkr	involves: C3H/HeH * C3H/HeJ * C57BL/6	MGI:3842143
cx45	Gli3^Xt-J/Gli3⁺ Tulp3^hhkr/Tulp3⁺	involves: C3H/HeH * C3H/HeJ * C57BL/6	MGI:3842144
cx46	Gli3^Xt-J/Gli3^Xt-J Tmem107^schlei/Tmem107^schlei	involves: C3H/HeJ * C3HeB/FeJ * C57BL/6J	MGI:5433096
cx47	Gli3^Xt-J/Gli3^Xt-J Tg(TCF/Lef1-lacZ)34Efu/0	involves: C3H/HeJ * C57BL/6	MGI:3795691

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	B6.C3-Gli3^Xt-J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:42454 )

• Background Sensitivity: homozygotes seldom survive beyond E14.5 on this background

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:109476 )

• at E13.5, embryos lack mammary bud 3

abnormal mammary line morphology ( J:109476 )

• mammary line formation is impaired

respiratory system

abnormal left lung morphology ( J:42454 )

• reduced width but not length in left lobe

abnormal right lung accessory lobe morphology ( J:42454 )

• accessory lobe reduced in both width and length

abnormal right lung caudal lobe morphology ( J:42454 )

• reduced width but not length in right caudal lobe

abnormal right lung middle lobe morphology ( J:42454 )

• right medial lobe of lung sometimes varies in shape

small lung ( J:42454 )

• lungs small in all homozygotes from E11.5 onward

decreased lung weight ( J:42454 )

• about 35% less than weights of littermate controls

embryo

increased embryo size ( J:42454 )

• consistently larger in size than control littermates

abnormal embryonic tissue morphology ( J:109476 )

• stratum intermedium is absent in mutants at E11.5

homeostasis/metabolism

edema ( J:42454 )

• spinal edema as early as E13.5 and in all homozygotes at E14.5

growth/size/body

increased embryo size ( J:42454 )

• consistently larger in size than control littermates

craniofacial

abnormal lambdoid suture morphology ( J:163175 )

• synostosis of the lambdoid sutures

• the sutural mesenchyme between the parietal and interparietal bones is thicker at E16.5, just before the occurrence of synostosis

• marker analysis indicates ectopic osteoblast differentiation in lambdoid sutures

• cell proliferation in the lambdoid sutures is increased at E16.5

wide metopic suture ( J:163175 )

• interfrontal suture is initially widened

wide sagittal suture ( J:163175 )

• sagittal suture is initially widened

abnormal neurocranium morphology ( J:163175 )

• calvaria is domed shaped and rectangular with an acute angle between the frontal or nasal bones

nervous system

increased forebrain size ( J:163175 )

• interfrontal and sagittal sutures are initially widened resulting in an expanded forebrain

skeleton

abnormal lambdoid suture morphology ( J:163175 )

• synostosis of the lambdoid sutures

• the sutural mesenchyme between the parietal and interparietal bones is thicker at E16.5, just before the occurrence of synostosis

• marker analysis indicates ectopic osteoblast differentiation in lambdoid sutures

• cell proliferation in the lambdoid sutures is increased at E16.5

wide metopic suture ( J:163175 )

• interfrontal suture is initially widened

wide sagittal suture ( J:163175 )

• sagittal suture is initially widened

abnormal neurocranium morphology ( J:163175 )

• calvaria is domed shaped and rectangular with an acute angle between the frontal or nasal bones

premature lambdoid suture closure ( J:163175 )

• mutants exhibit bilateral premature fusion of the parietal and interparietal bones across the lambdoid sutures at E18.5; suture fuses between E16.5 and E18.5

integument

abnormal mammary gland bud morphology ( J:109476 )

• at E13.5, embryos lack mammary bud 3

abnormal mammary line morphology ( J:109476 )

• mammary line formation is impaired

abnormal epidermis stratum basale morphology ( J:109476 )

• in E12.5 embryos, cells of the stratum germinativum are cylindrical, slightly enlarged along the width of the mammary line and covered with periderm

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129/Sv * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:121609 )

• digits have lost their identity with some digits consisting of three phalanges that are usually undivided and longer than those in Gli3^tm2Blnw homozygotes

abnormal phalanx morphology ( J:121609 )

• phalanges in some digits are undivided and longer than those in Gli3^tm2Blnw homozygotes

• rarely extra phalanges element branch from the metatarsals

• however, ossification occurs at most proximal and distal phalanges

polydactyly ( J:121609 )

• at E16.5, some mice have 6 to 8 digits that lacked identity

absent tibia ( J:121609 )

• at E16.5, in some mice

skeleton

abnormal phalanx morphology ( J:121609 )

• phalanges in some digits are undivided and longer than those in Gli3^tm2Blnw homozygotes

• rarely extra phalanges element branch from the metatarsals

• however, ossification occurs at most proximal and distal phalanges

absent tibia ( J:121609 )

• at E16.5, in some mice

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129/Sv * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:121554 )

• similar to the phenotype seen in Gli3^Xt-J Gas1^tm2Fan double homozygotes

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: C3H * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:4086 )

• animals that survive to birth die within 2 days after birth

prenatal lethality, incomplete penetrance ( J:4086 )

• many mutants die embryonically with a wide range of defects

craniofacial

abnormal cranium morphology ( J:38381 )

• external nasal processes are reduced

absent neurocranium ( J:38381 )

• skull vault fails to form

abnormal maxilla morphology ( J:38381 )

• the maxillary region is enlarged

abnormal craniofacial development ( J:4086 )

• enlarged maxillary arch

• reduced external nasal process

abnormal tooth development ( J:38381 )

• occurs in some mice

cleft palate ( J:38381 )

• occurs in some mice

abnormal ear position ( J:4086 )

• misplaced ears

skeleton

abnormal cranium morphology ( J:38381 )

• external nasal processes are reduced

absent neurocranium ( J:38381 )

• skull vault fails to form

abnormal tooth development ( J:38381 )

• occurs in some mice

abnormal maxilla morphology ( J:38381 )

• the maxillary region is enlarged

abnormal long bone morphology ( J:38381 )

increased diameter of humerus ( J:38381 )

• slight thickening of the humerus

short humerus ( J:38381 )

• slight shortening of the humerus

short radius ( J:38381 )

• slight shortening of the radius

increased diameter of radius ( J:38381 )

• slight thickening of the radius

short ulna ( J:38381 )

• slight shortening of the ulna

increased diameter of ulna ( J:38381 )

• slight thickening of the ulna

short tibia ( J:38381 )

• severe truncation of the tibia is observed

abnormal sternum morphology ( J:38381 )

• sternum is unfused

abnormal vertebral arch morphology ( J:38381 )

• C1 and C2 neural arches are fused

• neural arches of other cervical vertebrae are expanded and have irregular shapes

limbs/digits/tail

polydactyly ( J:4086 , J:38381 )

• present on all feet (J:4086)

• forelimb exhibits severe polydactyly (7-8 digits) and hindlimb exhibits milder polydactyly (6 digits) (J:38381)

syndactyly ( J:4086 )

• present on all feet

increased diameter of humerus ( J:38381 )

• slight thickening of the humerus

short humerus ( J:38381 )

• slight shortening of the humerus

short radius ( J:38381 )

• slight shortening of the radius

increased diameter of radius ( J:38381 )

• slight thickening of the radius

short ulna ( J:38381 )

• slight shortening of the ulna

increased diameter of ulna ( J:38381 )

• slight thickening of the ulna

short tibia ( J:38381 )

• severe truncation of the tibia is observed

abnormal embryonic autopod plate morphology ( J:4086 )

• at E12, mutant embryos show a widening in the preaxial and postaxial areas of the footplates, resulting in a paddle-shaped foot with polydactyly

nervous system

incomplete rostral neuropore closure ( J:4086 )

• neural tube closure is largely normal, although an opening around the midbrain region is seen

abnormal brain morphology ( J:4086 )

• gross malformations of the brain

exencephaly ( J:4086 )

• midbrain exencephaly

hearing/vestibular/ear

abnormal ear position ( J:4086 )

• misplaced ears

homeostasis/metabolism

edema ( J:4086 )

vision/eye

abnormal eye development ( J:4086 )

• poorly developed eyes

digestive/alimentary system

cleft palate ( J:38381 )

• occurs in some mice

embryo

incomplete rostral neuropore closure ( J:4086 )

• neural tube closure is largely normal, although an opening around the midbrain region is seen

integument

abnormal vibrissa morphology ( J:4086 )

• abnormal patterns of mystacial and supra-orbital hair

abnormal vibrissa number ( J:4086 )

• abnormal number of mystacial and supra-orbital hair

growth/size/body

abnormal tooth development ( J:38381 )

• occurs in some mice

cleft palate ( J:38381 )

• occurs in some mice

abnormal ear position ( J:4086 )

• misplaced ears

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Greig cephalopolysyndactyly syndrome		DOID:14761	OMIM:175700	J:4086

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:159210 )

• distal truncations of the forelimb skeleton and loss of the autopod at E14.5

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:42454 )

N	• Background Sensitivity: homozygotes survive beyond E14.5 and up to birth at least

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:112460 )

• at 13.5, all lack of mammary bud pair number 5 and most lack bud number 3; a small proportion show reduction and/or misplacement of bud number 3

respiratory system

abnormal left lung morphology ( J:42454 )

• left lobe reduced in both width and length

abnormal right lung accessory lobe morphology ( J:42454 )

• accessory lobe reduced in both width and length

abnormal right lung caudal lobe morphology ( J:42454 )

• reduced width but not length in right caudal lobe

small lung ( J:42454 )

• lungs small in all homozygotes from E17.5 through to newborn pups

integument

abnormal mammary gland bud morphology ( J:112460 )

• at 13.5, all lack of mammary bud pair number 5 and most lack bud number 3; a small proportion show reduction and/or misplacement of bud number 3

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: C3H/HeJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

edema ( J:152259 )

• at E14.5

limbs/digits/tail

polydactyly ( J:152259 )

• at E14.5

nervous system

exencephaly ( J:152259 )

• at E14.5

skeleton

abnormal sternum morphology ( J:152259 )

abnormal xiphoid process morphology ( J:152259 )

• enlarged at E18.5

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: C3H/HeJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:184012 )

• additional anterior digits are formed but the anterior most digit 1 is lost

Allelic Composition	Gli3^Xt-J/Gli3⁺
Genetic Background	C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gli3^Xt-J/⁺

limbs/digits/tail

polydactyly ( J:27442 )

• duplication of digit 1 (thumb polydactyly) of the hindlimbs

Allelic Composition	Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129/Sv * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:121609 )

• there is an extra phalange in the first digit

skeleton

polyphalangy ( J:121609 )

• there is an extra phalange in the first digit

Allelic Composition	Gli3^Xt-J/Gli3⁺
Genetic Background	involves: C3H * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:38381 )

• display mild preaxial polydactyly in both fore- and hindlimbs

abnormal embryonic autopod plate morphology ( J:4086 )

• at day 12 of gestation, footpads are enlarged at the area destined to become digit 1

Allelic Composition	Gli3^Xt-J/Gli3⁺
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:207959 )

• in 4 of 17 forelimbs

Allelic Composition	Gli3^Xt-J/Gli3⁺
Genetic Background	involves: C3H/HeJ * C57BL/6J * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:42445 )

• 12% with unilateral anterior polydactyly involving the hind limbs only

Allelic Composition	Gli3^tm1Blnw/Gli3^Xt-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1Blnw mutation (0 available); any Gli3 mutation (80 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:118340 )

• die soon after birth

limbs/digits/tail

polydactyly ( J:118340 )

• develop 7 digits in both the forelimbs and hindlimbs; the two extra digits are either partial or complete and resemble the biphalangeal first digit

Allelic Composition	Gli3^tm1.2Zllr/Gli3^Xt-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1.2Zllr mutation (0 available); any Gli3 mutation (80 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:184012 )

• additional anterior digits are formed but the anterior most digit 1 is lost

nervous system

abnormal brain morphology ( J:184012 )

• brain abnormalities similar to mice homozygous for Gli3^Xt-J

vision/eye

abnormal eye morphology ( J:184012 )

• eye abnormalities similar to mice homozygous for Gli3^Xt-J

Allelic Composition	Gli3^Mos1/Gli3^Xt-J
Genetic Background	involves: BALB/cJ * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Mos1 mutation (0 available); any Gli3 mutation (80 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:136642 )

• no mice are recovered at weaning

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Hand2^tm1.1Zllr/Hand2^tm1.2Zllr Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Hand2^tm1.1Zllr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm1.2Zllr mutation (0 available); any Hand2 mutation (12 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:159210 )

• digits with undetermined identities in forelimb autopod at E14.5

postaxial polydactyly ( J:159210 )

• extreme postaxial polydactyly in forelimb autopod at E14.5

preaxial polydactyly ( J:159210 )

• extreme preaxial polydactyly in forelimb autopod at E14.5

abnormal forelimb stylopod morphology ( J:159210 )

• shortening of the stylopod in forelimbs at E14.5

abnormal forelimb zeugopod morphology ( J:159210 )

• symmetrical forelimb zeugopodal bones and elbow joints at E14.5

abnormal limb development ( J:159210 )

• duplicated elbow-like structure in forelimbs at E14.5

• stunted forelimbs at E14.5

• little phenotypic variability

• survival of the zeugopod and autopod progenitors is restored in contrast to Tg(Prrx1-cre)1Cjt/o, Hand2^tm1.1Zllr, Hand2^tm1.2Zllr limbs

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Gt(ROSA)26Sor^{tm2(Gli2*)Flng}/Gt(ROSA)26Sor⁺ Ihh^tm1Amc/Ihh^tm1Amc Tg(Col2a1-cre)3Amc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Gt(ROSA)26Sor^{tm2(Gli2*)Flng} mutation (0 available); any Gt(ROSA)26Sor mutation (985 available)
Ihh^tm1Amc mutation (1 available); any Ihh mutation (22 available)
Tg(Col2a1-cre)3Amc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:154905 )

• mice die at birth

skeleton

skeleton phenotype ( J:154905 )

N	• unlike in Ihh^tm1Amc Gli3^Xt-J homozygotes the marrow cavity and hypertrophic chondrocyte are normal

abnormal long bone diaphysis morphology ( J:154905 )

• the growth region cartilage is longer than in wild-type mice

• the columnar zone contains areas of disorganization unlike in wild-type mice

• however, orthotopic bone collar formation is normal unlike in Ihh^tm1Amc homozygotes

growth/size/body

decreased body size ( J:154905 )

• while larger than Ihh^tm1Amc homozygotes at E18.5, mice are smaller than wild-type mice

limbs/digits/tail

short limbs ( J:154905 )

• while larger than in Ihh^tm1Amc homozygotes at E18.5, limbs are shorter than in wild-type mice

Allelic Composition	Gli3^Xt-J/Gli3⁺ Spop^{tm1c(KOMP)Mbp}/Spop^{tm1c(KOMP)Mbp} Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Spop^{tm1c(KOMP)Mbp} mutation (0 available); any Spop mutation (35 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:239074 )

N	• length of metacarpals, metatarsals and phalanges are similar to controls and significantly longer than in conditional mice wild-type for Gli3 • near wild-type levels of bone density and thickness of bone spicules are restored in the femur

Allelic Composition	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺ Gli3^Xt-J/Gli3⁺
Genetic Background	either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:73074 )

• females die by 6 weeks of age

limbs/digits/tail

polydactyly ( J:73074 )

• polydactyl is enhanced compared to mice heterozygous for Gli3^Xt-J alone

reproductive system

male infertility ( J:73074 )

• all males are sterile

integument

progressive hair loss ( J:73074 )

• hair loss is more severe compared to mice heterozygous for Gli2^{tm3.1(Gli2)Alj} alone

Allelic Composition	Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

mandible hypoplasia ( J:38381 )

• coronoid, condylar, angular and dental processes are hypoplastic

limbs/digits/tail

abnormal digit morphology ( J:38381 )

• on forelimbs, there is a postaxial stub of an extra digit

polydactyly ( J:38381 )

• display more severe preaxial polydactyly compared to Gli2 homozygotes

short humerus ( J:38381 )

• shortening of the humerus

short radius ( J:38381 )

• shortening of the radius; shortening is more severe than in the ulna

short ulna ( J:38381 )

• shortening of the ulna, although not as severe as the radius

short femur ( J:38381 )

short fibula ( J:38381 )

• not as severe as the tibia

short tibia ( J:38381 )

skeleton

abnormal skeleton morphology ( J:38381 )

• show an exacerbated phenotype in various skeletal elements with respect to Gli2 nulls

mandible hypoplasia ( J:38381 )

• coronoid, condylar, angular and dental processes are hypoplastic

abnormal long bone morphology ( J:38381 )

short humerus ( J:38381 )

• shortening of the humerus

short radius ( J:38381 )

• shortening of the radius; shortening is more severe than in the ulna

short ulna ( J:38381 )

• shortening of the ulna, although not as severe as the radius

short femur ( J:38381 )

short fibula ( J:38381 )

• not as severe as the tibia

short tibia ( J:38381 )

split sternum ( J:38381 )

• sternum is split rostrally and improperly segmented

abnormal vertebrae development ( J:38381 )

• there are severe abnormalities in chondrogenesis of ventral vertebral components

abnormal cartilage development ( J:38381 )

• there are severe abnormalities in chondrogenesis of ventral vertebral components

Allelic Composition	Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:38381 )

• double homozygotes die before E10.5

Allelic Composition	Gli2^tm1Alj/Gli2⁺ Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:38381 )

• not different from Gli3 heterozygotes

Allelic Composition	Gli2^tm1Alj/Gli2⁺ Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:38381 )

• show an enhancement of the Gli3 null phenotype

polyphalangy ( J:38381 )

fusion of vertebral arches ( J:38381 )

• neural arches of other cervical vertebrae are fused in addition to the fusion of the C1 and C2 neural arches

limbs/digits/tail

polyphalangy ( J:38381 )

Allelic Composition	Gli3^Xt-J/Gli3⁺ Sox10^tm1Weg/Sox10⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belted ( J:136642 )

• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10^tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region

belly spot ( J:136642 )

• mice exhibit ventral hypopigmentation

hypopigmentation ( J:136642 )

• mice exhibit more hypopigmentation than in either single heterozygote

integument

belted ( J:136642 )

belly spot ( J:136642 )

• mice exhibit ventral hypopigmentation

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Ihh^tm1Amc/Ihh^tm1Amc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Ihh^tm1Amc mutation (1 available); any Ihh mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone marrow cavity morphology ( J:154905 )

• the marrow cavity does not develop unlike in wild-type mice

• however, hypertrophic chondrocytes are normal

abnormal perichondrium morphology ( J:154905 )

• at E18.5, mice fail to exhibit bone deposition in the perichondrium flanking the hypertrophic regions where the bone collar normally forms in the long bones in wild-type mice

Allelic Composition	Gli2^tm1Alj/Gli2^tm1Alj Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:92067 )

• reduced numbers of motor neurons in the thoracic and lumbar cord of embryos

• motor neuron progenitors shifted to more ventral locations and increased 20% in thoracic region while being reduced about 15% in lumbar region

abnormal ventral interneuron morphology ( J:92067 )

• V1, V2a, and V2b interneurons expand down into the ventral midline becoming intermingled with one another and with motor neurons in embryos

abnormal ventral interneuron 0 morphology ( J:92067 )

• V0 interneurons are normal but increased in numbers in embryos

abnormal ventral interneuron 1 morphology ( J:92067 )

• V1 interneurons are also increased in numbers but only in the thoracic region of embryos

abnormal ventral interneuron 2 morphology ( J:92067 )

• V2 interneurons are reduced in number in embryos

abnormal ventral interneuron 3 morphology ( J:92067 )

• V3 interneurons absent in thoracic and lumbar spinal cord of embryos

Allelic Composition	Gli1^tm1Alj/Gli1^tm1Alj Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm1Alj mutation (0 available); any Gli1 mutation (48 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:60986 )

Allelic Composition	Bmp4^tm1Blh/Bmp4⁺ Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4^tm1Blh mutation (2 available); any Bmp4 mutation (21 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:42445 )

• apoptotic area in the preaxial mesoderm is completely absent at 12.5 days

• post axial apoptotic areas are normal

polydactyly ( J:42445 )

• 100% with unilateral anterior polydactyly involving the hind limbs only

• defect extends into the metatarsals

Allelic Composition	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm3(Gli1)Alj mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:112460 )

• most embryos lack mammary bud pair number 3 and number 5

integument

abnormal mammary gland bud morphology ( J:112460 )

• most embryos lack mammary bud pair number 3 and number 5

Allelic Composition	Gli2^tm2.1Alj/Gli2⁺ Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:112460 )

• some embryos lack mammary bud pair number 3 and number 5

integument

abnormal mammary gland bud morphology ( J:112460 )

• some embryos lack mammary bud pair number 3 and number 5

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:112460 )

N	• embryos show normal mammary gland development

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:112460 )

• embryos die around E10.5

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk20^tm1.1Jegg mutation (0 available); any Cdk20 mutation (10 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:243907 )

• variable rescue of floor plate specification

nervous system

abnormal neural tube morphology ( J:243907 )

• variable rescue of floor plate specification

Allelic Composition	Cdk20^tm1.1Jegg/Cdk20^tm1.1Jegg Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:243907 )

N	• restoration of floor plate patterning

Allelic Composition	Gas1^tm2Fan/Gas1^tm2Fan Gli3^Xt-J/Gli3^Xt-J
Genetic Background	involves: 129/Sv * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas1^tm2Fan mutation (0 available); any Gas1 mutation (14 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:121554 )

• similar to the phenotype seen in Gli3^Xt-J homozygotes

Allelic Composition	Gli3^Xt-J/Gli3⁺ Rr26^tm1Svok/Rr26^tm1Svok
Genetic Background	involves: 129X1/SvJ * C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Rr26^tm1Svok mutation (0 available); any Rr26 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:207959 )

• in 3 of 8 hindlimbs

• of the thumb in all forelimbs

Allelic Composition	Gli3^Xt-J/Gli3⁺ Rr26^tm1Svok/Rr26⁺
Genetic Background	involves: 129X1/SvJ * C3H/HeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:207959 )

• in 23 of 28 forelimbs

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Ski^tm1Cco/Ski⁺
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Ski^tm1Cco mutation (4 available); any Ski mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:80205 )

• 3 or more extra digits are seen

skeleton

abnormal skeleton development ( J:80205 )

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tbx15^de-H/Tbx15^de-H
Genetic Background	involves: C3H * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Tbx15^de-H mutation (1 available); any Tbx15 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

small acromion ( J:101708 )

• the acromion is more severely reduced than in either single mutant

small scapula ( J:101708 )

• severe reduction of the scapular blade when compared to either single mutant, lacking the posterior part of the blade

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tbx15^de-H/Tbx15⁺
Genetic Background	involves: C3H * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal scapula morphology ( J:101708 )

• scapular blade is broader

scapular bone foramen ( J:101708 )

• scapular foramen is enlarged in comparison with single Tbx15 mutants

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tulp3^hhkr/Tulp3⁺
Genetic Background	involves: C3H/HeH * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Tulp3^hhkr mutation (1 available); any Tulp3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polysyndactyly ( J:147584 )

• with seven to nine digits

Allelic Composition	Gli3^Xt-J/Gli3⁺ Tulp3^hhkr/Tulp3^hhkr
Genetic Background	involves: C3H/HeH * C3H/HeJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:147584 )

• mice exhibit more severe polydactyly than in Tulp3^hhkr homozygotes with seven or eight digits

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tulp3^hhkr/Tulp3^hhkr
Genetic Background	involves: C3H/HeH * C3H/HeJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:147584 )

• mice do not survive to E15.5

Allelic Composition	Gli3^Xt-J/Gli3⁺ Tulp3^hhkr/Tulp3⁺
Genetic Background	involves: C3H/HeH * C3H/HeJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:147584 )

• mice exhibit a single extra digit on most limbs

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: C3H/HeJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• dorsal expansion of motor neuron progenitors and V2 interneuron progenitors observed in Tmem107^schlei homozygotes is exacerbated

nervous system

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• dorsal expansion of motor neuron progenitors and V2 interneuron progenitors observed in Tmem107^schlei homozygotes is exacerbated

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Tg(TCF/Lef1-lacZ)34Efu mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland embryonic development ( J:112460 )

abnormal mammary placode morphology ( J:112460 )

• placode 3 formation is compromised by E11

integument

abnormal mammary gland embryonic development ( J:112460 )

abnormal mammary placode morphology ( J:112460 )

• placode 3 formation is compromised by E11

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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