All Phenotypes Yaa MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Yaa
accelerated autoimmunity and lymphoproliferation
MGI:1856277

Summary

33 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Bxs6^BXSB/MpJ/Bxs6^BXSB/MpJ X/Yaa	B10.BXSB-(D13Mit3-D13Mit78) Yaa	MGI:3836730
cx2	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tlr7^tm1Flv/Y X/Yaa	B6.Cg-Fcgr2b^tm1Ttk Tlr7^tm1Flv Yaa	MGI:5488508
cx3	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk X/Yaa	B6.Cg-Fcgr2b^tm1Ttk Yaa	MGI:5488509
cx4	Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa	B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa	MGI:3804683
cx5	Tlr7^tm1Flv/Y X/Yaa	B6.Cg-Tlr7^tm1Flv Yaa	MGI:5488500
cx6	Il21r^tm1Wjl/Il21r^tm1Wjl X/Yaa	BXSB.129(Cg)-Il21r^tm1Wjl/Dcr	MGI:3835838
cx7	B2m^tm1Unc/B2m^tm1Unc X/Yaa	BXSB.129P2(B6)-B2m^tm1Unc/Dcr	MGI:6094201
cx8	H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe X/Yaa	BXSB.129P2(B6)-H2-K1^b-tm1Bpe H2-D1^b-tm1Bpe/Dcr	MGI:6094247
cx9	Tcra^tm1Mjo/Tcra^tm1Mjo X/Yaa	BXSB.129P2(Cg)-Tcra^tm1Mjo/Theo	MGI:6154363
cx10	Cd8a^tm1Mak/Cd8a^tm1Mak X/Yaa	BXSB.129S2(B6)-Cd8a^tm1Mak/4Dcr	MGI:6104236
cx11	Ighm^tm1Cgn/Ighm^tm1Cgn X/Yaa	BXSB.129S2(B6)-Ighm^tm1Cgn/Dcr	MGI:6107168
cx12	Tap1^tm1Arp/Tap1^tm1Arp X/Yaa	BXSB.129S2(B6)-Tap1^tm1Arp/Dcr	MGI:6094248
cx13	Cd1d1^tm1Luc/Cd1d1^tm1Luc X/Yaa	BXSB.129S6(B6)-Cd1d1^tm1Luc/Dcr	MGI:6094191
cx14	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr X/Yaa	BXSB.129X1-Fcgrt^tm1Dcr/Dcr	MGI:6094246
cx15	Il15^tm1Imx/Il15^tm1Imx X/Yaa	BXSB.B6-Il15^tm1Imx/Dcr	MGI:6105930
cx16	Prf1^tm1Sdz/Prf1^tm1Sdz X/Yaa	BXSB.B6-Prf1^tm1Sdz/Dcr	MGI:6105950
cx17	Cd8a^tm1Mak/Cd8a^tm1Mak Il15^tm1Imx/Il15^tm1Imx X/Yaa	BXSB.Cg-Cd8a^tm1Mak Il15^tm1Imx/Dcr	MGI:6105946
cx18	ll/ll X/Yaa	BXSB/MpJScr-ll	MGI:3624981
cx19	Nba10^NZB/Nba10^NZB X/Yaa	C57BL/6-Nba2 Yaa	MGI:3529942
cx20	Dsg4^hage/Dsg4^hage Fas^lpr/Fas^lpr X/Yaa	EOD-Dsg4^hage	MGI:3812133
cx21	Fcgr2b^tm1Ttk/Fcgr2b⁺ X/Yaa	involves: 129S4/SvJae * C57BL/6 * SB/Le	MGI:4360218
cx22	Btk^m1Anu/Btk^m1Anu X/Yaa	involves: BXSB/MpJ * C57BL/6JAnu * SB/Le	MGI:5564926
cx23	Fcgr2b^tm1.2Jsv/Fcgr2b⁺ X/Yaa	involves: C57BL/6 * FVB/N * SB/Le	MGI:5427950
ot24	X/Yaa	B6.SB-Yaa/J	MGI:5488504
ot25	X/Yaa	BXSB/MpJ	MGI:3624973
ot26	X/Yaa	BXSB/MpJScr	MGI:3624982
ot27	X/Yaa	(C57BL/6J x BXSB)F1	MGI:3624944
ot28	X/Yaa	involves: BXSB * NZB	MGI:3624970
ot29	X/Yaa	(NZB x B6.SB/Le-Yaa)F1	MGI:4360217
ot30	X/Yaa	(NZB x BXSB)F1	MGI:3624942
ot31	X/Yaa	(NZW x BXSB)F1	MGI:3624975
ot32	X/Yaa	(NZW x SB)F1	MGI:3624974
ot33	X/Yaa	(SJL/J x BXSB)F1	MGI:3624943

Allelic Composition	Bxs6^BXSB/MpJ/Bxs6^BXSB/MpJ X/Yaa
Genetic Background	B10.BXSB-(D13Mit3-D13Mit78) Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bxs6^BXSB/MpJ mutation (0 available); any Bxs6 mutation (0 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:145049 )

autoimmune response ( J:145049 )

• increased levels of gp70 immune complex formation

increased autoantibody level ( J:145049 )

• increased gp70 autoantibody titers

increased anti-double stranded DNA antibody level ( J:145049 )

increased anti-single stranded DNA antibody level ( J:145049 )

glomerulonephritis ( J:145049 )

• increased glomerulonephritis incidence and severity

• decreased survival

hematopoietic system

enlarged spleen ( J:145049 )

renal/urinary system

glomerulonephritis ( J:145049 )

• increased glomerulonephritis incidence and severity

• decreased survival

growth/size/body

enlarged spleen ( J:145049 )

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tlr7^tm1Flv/Y X/Yaa
Genetic Background	B6.Cg-Fcgr2b^tm1Ttk Tlr7^tm1Flv Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:127600 )

• survival is prolonged compared to mutant mice wild-type for Tlr7

immune system

enlarged spleen ( J:127600 )

• less severe at 5 months of age compared to mutant mice wild-type for Tlr7

abnormal splenocyte physiology ( J:127600 )

• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7

autoimmune response ( J:127600 )

• autoantibodies show a homogeneous nuclear pattern

increased susceptibility to systemic lupus erythematosus ( J:127600 )

• develop a lupus like syndrome at a later age and in lower numbers compared to mutant mice wild-type for Tlr7

increased anti-nuclear antigen antibody level ( J:127600 )

• increase in anti-RNA IgG levels in the serum at 4 - 6 months of age is less severe than in mutant mice wild-type for Tlr7 and is similar to mice homozygous for Fcgr2b^tm1Ttk alone

renal/urinary system

abnormal kidney morphology ( J:127600 )

• kidney disease is less severe at 5 months of age compared to mutant mice wild-type for Tlr7

hematopoietic system

enlarged spleen ( J:127600 )

• less severe at 5 months of age compared to mutant mice wild-type for Tlr7

abnormal splenocyte physiology ( J:127600 )

• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7

growth/size/body

enlarged spleen ( J:127600 )

• less severe at 5 months of age compared to mutant mice wild-type for Tlr7

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk X/Yaa
Genetic Background	B6.Cg-Fcgr2b^tm1Ttk Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:127600 )

• moribund at 5 months of age

immune system

enlarged spleen ( J:127600 )

autoimmune response ( J:127600 )

• autoantibodies show a nucleolar pattern

increased susceptibility to systemic lupus erythematosus ( J:127600 )

increased anti-nuclear antigen antibody level ( J:127600 )

• marked increase in anti-RNA IgG levels in the serum at 4 - 6 months of age

renal/urinary system

abnormal kidney morphology ( J:127600 )

• kidney disease

hematopoietic system

enlarged spleen ( J:127600 )

growth/size/body

enlarged spleen ( J:127600 )

Allelic Composition	Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa
Genetic Background	B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:137656 )

• 20% monocytosis incidence in males

• monocytosis incidence is decreased compared to C57BL/6-Nba2^NZB Yaa males (71% incidence)

abnormal immune serum protein physiology ( J:137656 )

• increased production of retroviral gp70 immune complex compared to wild-type males

increased anti-chromatin antibody level ( J:137656 )

glomerulonephritis ( J:137656 )

• 25% incidence of lethal lupus nephritis in males by 14 months of age

• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males

• increased glomerular lesion score compared to wild-type males

renal/urinary system

glomerulonephritis ( J:137656 )

• 25% incidence of lethal lupus nephritis in males by 14 months of age

• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males

• increased glomerular lesion score compared to wild-type males

hematopoietic system

increased monocyte cell number ( J:137656 )

• 20% monocytosis incidence in males

• monocytosis incidence is decreased compared to C57BL/6-Nba2^NZB Yaa males (71% incidence)

Allelic Composition	Tlr7^tm1Flv/Y X/Yaa
Genetic Background	B6.Cg-Tlr7^tm1Flv Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Flv mutation (1 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:127600 )

N	• spleen marginal zone B cell numbers are similar to wild-type controls • splenocyte proliferation in response to imiquimod is similar to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	systemic lupus erythematosus	DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:127600

Allelic Composition	Il21r^tm1Wjl/Il21r^tm1Wjl X/Yaa
Genetic Background	BXSB.129(Cg)-Il21r^tm1Wjl/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21r^tm1Wjl mutation (6 available); any Il21r mutation (42 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to systemic lupus erythematosus ( J:144484 )

mortality/aging

mortality/aging ( J:144484 , J:179430 )

• the hypergammaglobulinemia, autoantibody production, reduced frequencies of marginal zone B cells and monocytosis, renal disease, and premature morbidity that are found in Yaa bearing mice with at least one wildtype copy of the interleukin 21 receptor are ameliorated or prevented by the disruption of the interleukin 21 receptor (J:144484)

• unlike IL21R heterozygous B2M null controls, these double homozygotes do not develop the Lupus-like autoimmune syndrome caused by Yaa and generally survive beyond 40 weeks of age (J:179430)

Allelic Composition	B2m^tm1Unc/B2m^tm1Unc X/Yaa
Genetic Background	BXSB.129P2(B6)-B2m^tm1Unc/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Unc mutation (38 available); any B2m mutation (122 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only 18 weeks

increased anti-nuclear antigen antibody level ( J:179430 )

• despite the inability to generate serum IgG, there is increased anti-nuclear antibodies in the serum at 14 weeks of age, that is higher than that of BXSB/MpJ males with normal B2M expression

mortality/aging

premature death ( J:179430 )

Allelic Composition	H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe X/Yaa
Genetic Background	BXSB.129P2(B6)-H2-K1^b-tm1Bpe H2-D1^b-tm1Bpe/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1^b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1^b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of MHC class I molecules intensifies the severity to a mean survival of only 25 weeks of age

mortality/aging

premature death ( J:179430 )

Allelic Composition	Tcra^tm1Mjo/Tcra^tm1Mjo X/Yaa
Genetic Background	BXSB.129P2(Cg)-Tcra^tm1Mjo/Theo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mjo mutation (7 available); any Tcra mutation (101 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:120153 )

• due to the absense of alpha/beta T cells these Yaa-bearing males do not develop hypergammaglobulinemia, anti-chromatin auto-antibodies, enlarged lymph nodes or spleen, hemolytic anemia, immune complex glomerulonephritis, monocytosis, or the lupus-like autoimmune disease that normally causes premature death in Yaa-bearing males on the BXSB background, but instead these males are reported to live beyond 300 days

Allelic Composition	Cd8a^tm1Mak/Cd8a^tm1Mak X/Yaa
Genetic Background	BXSB.129S2(B6)-Cd8a^tm1Mak/4Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8a^tm1Mak mutation (7 available); any Cd8a mutation (39 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• compared with BXSB/MpJ males that carry Yaa, the additional ablation of CD8A accelerates the mortality from the spontaneous lupus erythematosus-like syndrome such that mortality occurs as early as 12 to 15 weeks of age and mean survival is only 20 weeks of age

mortality/aging

premature death ( J:179430 )

Allelic Composition	Ighm^tm1Cgn/Ighm^tm1Cgn X/Yaa
Genetic Background	BXSB.129S2(B6)-Ighm^tm1Cgn/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (17 available); any Ighm mutation (56 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to systemic lupus erythematosus ( J:206236 )

• this null allele diminishes the B cells essential for the Yaa-induced development of Lupus-like autoimmune disease such that these males survive beyond 40 weeks, and do not have the increased splenic populations of CD4+ T cells or CD11b+ monocytes, nor is there elevated ICOS expression in splenic T cells

Allelic Composition	Tap1^tm1Arp/Tap1^tm1Arp X/Yaa
Genetic Background	BXSB.129S2(B6)-Tap1^tm1Arp/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (51 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of Tap1 intensifies the severity to a mean survival of only 23 weeks of ag

Allelic Composition	Cd1d1^tm1Luc/Cd1d1^tm1Luc X/Yaa
Genetic Background	BXSB.129S6(B6)-Cd1d1^tm1Luc/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179430 )

• disruption of Cd1d1 does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males

Allelic Composition	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr X/Yaa
Genetic Background	BXSB.129X1-Fcgrt^tm1Dcr/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrt^tm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179430 )

• disruption of Fcgrt does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males

Allelic Composition	Il15^tm1Imx/Il15^tm1Imx X/Yaa
Genetic Background	BXSB.B6-Il15^tm1Imx/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15^tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:179430 )

mortality/aging

premature death ( J:179430 )

Allelic Composition	Prf1^tm1Sdz/Prf1^tm1Sdz X/Yaa
Genetic Background	BXSB.B6-Prf1^tm1Sdz/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1^tm1Sdz mutation (13 available); any Prf1 mutation (51 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

autoimmune response ( J:179430 )

• death as a result of the Yaa-induced SLE-like autoimmunity is slightly increased in the early segment of the mortality curve relative to Yaa-bearing controls without the null allele

mortality/aging

premature death ( J:179430 )

Allelic Composition	Cd8a^tm1Mak/Cd8a^tm1Mak Il15^tm1Imx/Il15^tm1Imx X/Yaa
Genetic Background	BXSB.Cg-Cd8a^tm1Mak Il15^tm1Imx/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8a^tm1Mak mutation (7 available); any Cd8a mutation (39 available)
Il15^tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179430 )

renal/urinary system

renal glomerular immunoglobulin deposits ( J:179430 )

• glomerular deposition of IgG at 14 weeks of age is more severe than that of BXSB/MpJ males

immune system

increased monocyte cell number ( J:179430 )

• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males

abnormal spleen B cell follicle morphology ( J:179430 )

• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age

increased splenocyte number ( J:179430 )

• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells

increased IgG1 level ( J:179430 )

• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

increased IgG2a level ( J:179430 )

• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

increased IgG2b level ( J:179430 )

• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

increased susceptibility to systemic lupus erythematosus ( J:179430 )

• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males homozygous for both null alleles die earlier than those with just one null allele and with a survival curve essentially the same as that of beta 2 microglobulin null Yaa carrying males, with a mean survival of only 18 weeks

increased anti-nuclear antigen antibody level ( J:179430 )

• elevated over BXSB/MpJ males at 6 and 14 weeks of age

hematopoietic system

increased monocyte cell number ( J:179430 )

• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males

abnormal spleen B cell follicle morphology ( J:179430 )

• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age

increased splenocyte number ( J:179430 )

• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells

increased IgG1 level ( J:179430 )

• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

increased IgG2a level ( J:179430 )

• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

increased IgG2b level ( J:179430 )

• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

Allelic Composition	ll/ll X/Yaa
Genetic Background	BXSB/MpJScr-ll

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ll mutation (0 available); any ll mutation (0 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:10973 )

• homozygous males have a mean life span of greater than 21 months, 3 to 4 time longer than non-homozygous males

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:10973 )

• seen in about 20% of mice

immune system

increased T cell derived lymphoma incidence ( J:10973 )

• seen in about 20% of mice

decreased CD4-positive, alpha-beta T cell number ( J:10973 )

• decrease in CD4+ T cells with age is less pronounced than in non-homozygous males

abnormal monocyte morphology ( J:10973 )

• do not develop severe monocytosis, unlike non-homozygous males

decreased IgG level ( J:10973 )

• at 3 to 5 months of age relative to non-homozygous males; however by 2 years of age IgG levels are similar to those in 2 to 3 month old early dying males

decreased susceptibility to autoimmune disorder ( J:10973 )

• minimal signs of autoimmune disease are seen at 8 months of age unlike non-homozygous males

decreased anti-nuclear antigen antibody level ( J:10973 )

• anti-nuclear antibodies are decreased relative to non-homozygous males

cardiovascular system

cardiovascular system phenotype ( J:10973 )

N	• no arteritic or degenerative vascular disease or myocardial infarctions are detected

neoplasm

increased lymphoma incidence ( J:10973 )

• seen in about 20% of mice

increased T cell derived lymphoma incidence ( J:10973 )

• seen in about 20% of mice

renal/urinary system

renal/urinary system phenotype ( J:10973 )

N	• glomerular lesions characteristic of aging are seen at 28 months of age but homozygotes do not develop proliferative glomerulonephritis

hematopoietic system

increased T cell derived lymphoma incidence ( J:10973 )

• seen in about 20% of mice

decreased CD4-positive, alpha-beta T cell number ( J:10973 )

• decrease in CD4+ T cells with age is less pronounced than in non-homozygous males

abnormal monocyte morphology ( J:10973 )

• do not develop severe monocytosis, unlike non-homozygous males

decreased IgG level ( J:10973 )

• at 3 to 5 months of age relative to non-homozygous males; however by 2 years of age IgG levels are similar to those in 2 to 3 month old early dying males

Allelic Composition	Nba10^NZB/Nba10^NZB X/Yaa
Genetic Background	C57BL/6-Nba2 Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:129409 , J:137656 )

• CD11b⁺ monocyte numbers increase as mice age (J:129409)

• a Gr-1^- monocyte subset is the dominant subset by 10 months of age (J:129409)

• increased susceptibility to monocytosis in males (J:137656)

• 71% monocytosis incidence in males (J:137656)

increased susceptibility to type III hypersensitivity reaction ( J:95829 )

• increased serum gp70 immune complex levels

abnormal immune serum protein physiology ( J:137656 )

• increased production of serum gp70 immune complex in males

increased susceptibility to autoimmune disorder ( J:95829 )

increased autoantibody level ( J:137656 )

• increased anti-ribonucleoprotein production in males

increased anti-nuclear antigen antibody level ( J:95829 )

• increased anti-chromatin and anti-DNA antibodies

increased anti-chromatin antibody level ( J:137656 )

glomerulonephritis ( J:95829 , J:137656 )

• susceptibility to severe glomerulonephritis (J:95829)

• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)

• increased lupus nephritis score (severity) in males (J:137656)

renal/urinary system

glomerulonephritis ( J:95829 , J:137656 )

• susceptibility to severe glomerulonephritis (J:95829)

• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)

• increased lupus nephritis score (severity) in males (J:137656)

hematopoietic system

increased monocyte cell number ( J:129409 , J:137656 )

• CD11b⁺ monocyte numbers increase as mice age (J:129409)

• a Gr-1^- monocyte subset is the dominant subset by 10 months of age (J:129409)

• 71% monocytosis incidence in males (J:137656)

• increased susceptibility to monocytosis in males (J:137656)

Allelic Composition	Dsg4^hage/Dsg4^hage Fas^lpr/Fas^lpr X/Yaa
Genetic Background	EOD-Dsg4^hage

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg4^hage mutation (0 available); any Dsg4 mutation (86 available)
Fas^lpr mutation (39 available); any Fas mutation (82 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:140028 )

• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live

growth/size/body

decreased body size ( J:140028 )

• mice are generally smaller than controls

immune system

abnormal mast cell morphology ( J:140028 )

• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls

abnormal effector T cell morphology ( J:140028 )

• the characteristic B220⁺Thy1⁺ T cells population found in the spleen of mice carrying the Fas^lps allele is reduced by more than 5-fold in these mice

hematopoietic system

abnormal mast cell morphology ( J:140028 )

• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls

abnormal effector T cell morphology ( J:140028 )

• the characteristic B220⁺Thy1⁺ T cells population found in the spleen of mice carrying the Fas^lps allele is reduced by more than 5-fold in these mice

integument

sparse hair ( J:140028 )

• pups have scanty growth of short hair on the head and back

abnormal hair follicle morphology ( J:140028 )

• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles

abnormal hair follicle orientation ( J:140028 )

• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer

absent vibrissae ( J:140028 )

• mice fail to grow vibrissae hairs

thick epidermis ( J:140028 )

• mice have thick skin with hyperplasia of the epidermis that is prone to injury

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypotrichosis 6		DOID:0110703	OMIM:607903	J:140028

Allelic Composition	Fcgr2b^tm1Ttk/Fcgr2b⁺ X/Yaa
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SB/Le

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:129409 )

• 58% of mice display monocytosis by 10 months of age with a Gr-1^- subset predominating

hematopoietic system

increased monocyte cell number ( J:129409 )

• 58% of mice display monocytosis by 10 months of age with a Gr-1^- subset predominating

Allelic Composition	Btk^m1Anu/Btk^m1Anu X/Yaa
Genetic Background	involves: BXSB/MpJ * C57BL/6JAnu * SB/Le

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btk^m1Anu mutation (1 available); any Btk mutation (21 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:104190 )

• in peripheral blood

immune system

decreased B cell number ( J:104190 )

• in peripheral blood

Allelic Composition	Fcgr2b^tm1.2Jsv/Fcgr2b⁺ X/Yaa
Genetic Background	involves: C57BL/6 * FVB/N * SB/Le

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2b^tm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179175 )

• mice exhibit greater cumulative death compared with Fcgr2b^tm1.2Sjv homozygotes

immune system

enlarged spleen ( J:179175 )

• compared with Fcgr2b^tm1.2Sjv homozygotes

increased monocyte cell number ( J:179175 )

• compared with single homozygotes

increased susceptibility to systemic lupus erythematosus ( J:179175 )

• mice develop moderate lupus unlike Fcgr2b^tm1.2Sjv homozygotes

• however, mice do not develop fatal lupus

increased anti-chromatin antibody level ( J:179175 )

• compared with single homozygotes

increased anti-double stranded DNA antibody level ( J:179175 )

• compared with single homozygotes

renal/urinary system

abnormal kidney morphology ( J:179175 )

• kidney pathology is increased compared to in Fcgr2b^tm1.2Sjv homozygotes

hematopoietic system

enlarged spleen ( J:179175 )

• compared with Fcgr2b^tm1.2Sjv homozygotes

increased monocyte cell number ( J:179175 )

• compared with single homozygotes

growth/size/body

enlarged spleen ( J:179175 )

• compared with Fcgr2b^tm1.2Sjv homozygotes

Allelic Composition	X/Yaa
Genetic Background	B6.SB-Yaa/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased splenocyte proliferation ( J:127600 )

• hyperresponsive to imiquimod induced splenocyte proliferation

decreased marginal zone B cell number ( J:127600 )

hematopoietic system

increased splenocyte proliferation ( J:127600 )

• hyperresponsive to imiquimod induced splenocyte proliferation

decreased marginal zone B cell number ( J:127600 )

cellular

increased splenocyte proliferation ( J:127600 )

• hyperresponsive to imiquimod induced splenocyte proliferation

Allelic Composition	X/Yaa
Genetic Background	BXSB/MpJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:6235 , J:7308 )

• mean longevity for males is 155 +/- 13 days compared to 442 +/- 29 days for littermate females (J:6235)

• castration does not significantly alter longevity (J:6235)

• median survival is 8 months (J:7308)

immune system

increased spleen weight ( J:6235 )

• 4-fold increase in spleen weight

abnormal B cell differentiation ( J:108760 )

• frequency of C3d receptor bearing cells is increased in young mice but declines with age

increased plasma cell number ( J:108760 )

• increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females

• frequency of Ig-bearing cells is increased in the thymus

abnormal T cell subpopulation ratio ( J:179430 )

• at 14 weeks of age, more than normal splenic CD4+ Foxp3+ CD25+ T cells and very few splenic CD8+ Foxp3+ CD25+ T cells and higher than normal expression of CD122 on CD8+ splenic T cells

increased monocyte cell number ( J:7308 )

• increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age

• at 8 months of age a 16-fold increase in monocytes is seen in males compared to females

abnormal spleen B cell follicle morphology ( J:179430 )

• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age

increased splenocyte number ( J:179430 )

• relative to BXSB.B6-Yaa+ at 14 weeks of age but not at 6 weeks of age

increased IgG1 level ( J:93740 , J:179430 )

(J:93740)

(J:179430)

increased IgG2a level ( J:179430 )

• relative to BXSB.B6-Yaa+ controls

increased IgG2b level ( J:179430 )

• relative to BXSB.B6-Yaa+ controls

increased IgG3 level ( J:93740 )

increased circulating interleukin-21 level ( J:93740 )

abnormal lymph node morphology ( J:6235 )

• infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node

enlarged lymph nodes ( J:6235 )

• moderately enlarged

• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males

increased susceptibility to autoimmune disorder ( J:6235 , J:108760 )

• accelerated autoimmune syndrome relative to females of the same strain (J:6235)

(J:108760)

increased anti-erythrocyte antigen antibody level ( J:6235 )

• erythrocyte autoantibodies were found in 7 of 13 males between 16 and 25 weeks of age

increased anti-nuclear antigen antibody level ( J:179430 )

• serum anti-nuclear antibodies are found at 6 weeks of age and increased levels at 14 weeks of age

glomerulonephritis ( J:6235 )

• acute to subacute exudative and proliferative glomerulonephritis

hematopoietic system

increased spleen weight ( J:6235 )

• 4-fold increase in spleen weight

abnormal B cell differentiation ( J:108760 )

• frequency of C3d receptor bearing cells is increased in young mice but declines with age

decreased erythrocyte cell number ( J:6235 )

• decreased at 16 weeks of age compared to C57BL/6J males

increased plasma cell number ( J:108760 )

• increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females

• frequency of Ig-bearing cells is increased in the thymus

abnormal T cell subpopulation ratio ( J:179430 )

• at 14 weeks of age, more than normal splenic CD4+ Foxp3+ CD25+ T cells and very few splenic CD8+ Foxp3+ CD25+ T cells and higher than normal expression of CD122 on CD8+ splenic T cells

increased monocyte cell number ( J:7308 )

• increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age

• at 8 months of age a 16-fold increase in monocytes is seen in males compared to females

abnormal spleen B cell follicle morphology ( J:179430 )

• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age

increased splenocyte number ( J:179430 )

• relative to BXSB.B6-Yaa+ at 14 weeks of age but not at 6 weeks of age

increased IgG1 level ( J:93740 , J:179430 )

(J:93740)

(J:179430)

increased IgG2a level ( J:179430 )

• relative to BXSB.B6-Yaa+ controls

increased IgG2b level ( J:179430 )

• relative to BXSB.B6-Yaa+ controls

increased IgG3 level ( J:93740 )

renal/urinary system

increased urine protein level ( J:7308 )

• seen at 4 months of age

glomerulonephritis ( J:6235 )

• acute to subacute exudative and proliferative glomerulonephritis

renal glomerular immunoglobulin deposits ( J:179430 )

• glomerular depositions of IgG are found at 14 weeks of age

homeostasis/metabolism

increased circulating interleukin-21 level ( J:93740 )

increased urine protein level ( J:7308 )

• seen at 4 months of age

growth/size/body

increased spleen weight ( J:6235 )

• 4-fold increase in spleen weight

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:6235 , J:7308 , J:108760

Allelic Composition	X/Yaa
Genetic Background	BXSB/MpJScr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:10973 )

immune system

decreased CD4-positive, alpha-beta T cell number ( J:10973 )

• pronounced decrease in CD4+ T cells with age

increased monocyte cell number ( J:10973 )

• monocytosis

increased IgG level ( J:10973 )

increased susceptibility to autoimmune disorder ( J:10973 )

• accelerated autoimmune syndrome

increased anti-nuclear antigen antibody level ( J:10973 )

• anti-nuclear antibody levels are elevated at 3 to 5 months of age

glomerulonephritis ( J:10973 )

• develop severe proliferative glomerulonephritis by 3 to 5 months of age

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:10973 )

• pronounced decrease in CD4+ T cells with age

increased monocyte cell number ( J:10973 )

• monocytosis

increased IgG level ( J:10973 )

renal/urinary system

glomerulonephritis ( J:10973 )

• develop severe proliferative glomerulonephritis by 3 to 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:10973

Allelic Composition	X/Yaa
Genetic Background	(C57BL/6J x BXSB)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:6235 )

• mean longevity for males is 332 +/- 14 days compared to 716 +/- 28 days for littermate females

immune system

enlarged lymph nodes ( J:6235 )

• moderately enlarged

• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males

increased susceptibility to autoimmune disorder ( J:6235 )

• accelerated autoimmune syndrome relative to reciprocal hybrid males

Allelic Composition	X/Yaa
Genetic Background	involves: BXSB * NZB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:6235 )

• mean longevity for males is 352 +/- 35 days while males with a wild-type Yaa allele survive 2.5 times longer

immune system

enlarged lymph nodes ( J:6235 )

• moderately enlarged

• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males

increased susceptibility to autoimmune disorder ( J:6235 )

• accelerated autoimmune syndrome relative to males with a wild-type Yaa allele

Allelic Composition	X/Yaa
Genetic Background	(NZB x B6.SB/Le-Yaa)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:129409 )

• CD11b⁺ monocyte numbers increase as mice age with a 3-fold increase by 10 months of age

hematopoietic system

increased monocyte cell number ( J:129409 )

• CD11b⁺ monocyte numbers increase as mice age with a 3-fold increase by 10 months of age

Allelic Composition	X/Yaa
Genetic Background	(NZB x BXSB)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:6235 )

• mean longevity for males is 166 +/- 6 days compared to 545 +/- 37 days for reciprocal hybrid males

immune system

increased spleen weight ( J:6235 )

• 20-fold increase in spleen weight by 20 weeks of age

abnormal lymph node morphology ( J:6235 )

• infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node

enlarged lymph nodes ( J:6235 )

• enlarged 13-fold at 18 to 20 weeks of age compared to reciprocal hybrid males and 6 fold compared to BXSB males

abnormal immune cell physiology ( J:6235 )

• spleen cell responses to phytohemagglutinin and concanavalin A are reduced and response to E. coli lipopolysaccharide is increased

• however, lymph node cell response to concanavalin A is similar to reciprocal hybrid males

• at 4 weeks of age, in vitro proliferation of spleen cells is increased 3-fold compared to cells from reciprocal hybrid males

increased susceptibility to autoimmune disorder ( J:6235 )

• accelerated autoimmune syndrome relative to reciprocal hybrid males

increased autoantibody level ( J:6235 )

• high titers of thymotoxic autoantibodies were found between 16 and 20 weeks of age in 15 of 16 males

increased anti-erythrocyte antigen antibody level ( J:6235 )

• erythrocyte autoantibodies were found in 16 of 17 males between 16 and 20 weeks of age

increased anti-nuclear antigen antibody level ( J:6235 )

• high titers of antinuclear antibody were found between 16 and 20 weeks of age in 14 of 16 males

homeostasis/metabolism

porphyria ( J:6235 )

• at 23 weeks of age protoporphyrin levels are 543 +/- 368 mg/100 ml packed erythrocytes compared to 39 +/- 1 mg in reciprocal hybrid males

hematopoietic system

increased spleen weight ( J:6235 )

• 20-fold increase in spleen weight by 20 weeks of age

decreased erythrocyte cell number ( J:6235 )

growth/size/body

increased spleen weight ( J:6235 )

• 20-fold increase in spleen weight by 20 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:6235

Allelic Composition	X/Yaa
Genetic Background	(NZW x BXSB)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:7276 )

• 50% mortality is seen at 4.5 months of age compared to 16 months in reciprocal hybrid males

immune system

abnormal immune serum protein physiology ( J:7276 )

• gp70 immune complexes are detectable earlier and reach higher concentrations compared to reciprocal hybrid males; however, the total concentration of free and complexed gp70 is similar

increased susceptibility to autoimmune disorder ( J:7276 )

• accelerated autoimmune syndrome relative to reciprocal hybrid males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:7276

Allelic Composition	X/Yaa
Genetic Background	(NZW x SB)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:7276 )

• 50% and 90% mortality are seen at 4.5 and 8 months of age, respectively, compared to 50% mortality at 15 months in reciprocal hybrid males

immune system

abnormal immune serum protein physiology ( J:7276 )

• gp70 immune complexes are detectable earlier and reach higher concentrations compared to reciprocal hybrid males

increased susceptibility to autoimmune disorder ( J:7276 )

• accelerated autoimmune syndrome relative to reciprocal hybrid males

glomerulonephritis ( J:7276 )

renal/urinary system

glomerulonephritis ( J:7276 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:7276

Allelic Composition	X/Yaa
Genetic Background	(SJL/J x BXSB)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:6235 )

• mean longevity for males is 308 +/- 26 days while only 8 of 16 reciprocal hybrid males died between 270 and 684 days

immune system

enlarged lymph nodes ( J:6235 )

• moderately enlarged

• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males

increased susceptibility to autoimmune disorder ( J:6235 )

• accelerated autoimmune syndrome relative to reciprocal hybrid males

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