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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Yaa
accelerated autoimmunity and lymphoproliferation
MGI:1856277
Summary 33 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Bxs6BXSB/MpJ/Bxs6BXSB/MpJ
X/Yaa
B10.BXSB-(D13Mit3-D13Mit78) Yaa MGI:3836730
cx2
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tlr7tm1Flv/Y
X/Yaa
B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa MGI:5488508
cx3
Fcgr2btm1Ttk/Fcgr2btm1Ttk
X/Yaa
B6.Cg-Fcgr2btm1Ttk Yaa MGI:5488509
cx4
Nba10NZB/Nba10NZB
Tlr7tm1Aki/Y
X/Yaa
B6.Cg-Nba10NZB Tlr7tm1Aki Yaa MGI:3804683
cx5
Tlr7tm1Flv/Y
X/Yaa
B6.Cg-Tlr7tm1Flv Yaa MGI:5488500
cx6
Il21rtm1Wjl/Il21rtm1Wjl
X/Yaa
BXSB.129(Cg)-Il21rtm1Wjl/Dcr MGI:3835838
cx7
B2mtm1Unc/B2mtm1Unc
X/Yaa
BXSB.129P2(B6)-B2mtm1Unc/Dcr MGI:6094201
cx8
H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
X/Yaa
BXSB.129P2(B6)-H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Dcr MGI:6094247
cx9
Tcratm1Mjo/Tcratm1Mjo
X/Yaa
BXSB.129P2(Cg)-Tcratm1Mjo/Theo MGI:6154363
cx10
Cd8atm1Mak/Cd8atm1Mak
X/Yaa
BXSB.129S2(B6)-Cd8atm1Mak/4Dcr MGI:6104236
cx11
Ighmtm1Cgn/Ighmtm1Cgn
X/Yaa
BXSB.129S2(B6)-Ighmtm1Cgn/Dcr MGI:6107168
cx12
Tap1tm1Arp/Tap1tm1Arp
X/Yaa
BXSB.129S2(B6)-Tap1tm1Arp/Dcr MGI:6094248
cx13
Cd1d1tm1Luc/Cd1d1tm1Luc
X/Yaa
BXSB.129S6(B6)-Cd1d1tm1Luc/Dcr MGI:6094191
cx14
Fcgrttm1Dcr/Fcgrttm1Dcr
X/Yaa
BXSB.129X1-Fcgrttm1Dcr/Dcr MGI:6094246
cx15
Il15tm1Imx/Il15tm1Imx
X/Yaa
BXSB.B6-Il15tm1Imx/Dcr MGI:6105930
cx16
Prf1tm1Sdz/Prf1tm1Sdz
X/Yaa
BXSB.B6-Prf1tm1Sdz/Dcr MGI:6105950
cx17
Cd8atm1Mak/Cd8atm1Mak
Il15tm1Imx/Il15tm1Imx
X/Yaa
BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr MGI:6105946
cx18
ll/ll
X/Yaa
BXSB/MpJScr-ll MGI:3624981
cx19
Nba10NZB/Nba10NZB
X/Yaa
C57BL/6-Nba2 Yaa MGI:3529942
cx20
Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa
EOD-Dsg4hage MGI:3812133
cx21
Fcgr2btm1Ttk/Fcgr2b+
X/Yaa
involves: 129S4/SvJae * C57BL/6 * SB/Le MGI:4360218
cx22
Btkm1Anu/Btkm1Anu
X/Yaa
involves: BXSB/MpJ * C57BL/6JAnu * SB/Le MGI:5564926
cx23
Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
involves: C57BL/6 * FVB/N * SB/Le MGI:5427950
ot24
X/Yaa B6.SB-Yaa/J MGI:5488504
ot25
X/Yaa BXSB/MpJ MGI:3624973
ot26
X/Yaa BXSB/MpJScr MGI:3624982
ot27
X/Yaa (C57BL/6J x BXSB)F1 MGI:3624944
ot28
X/Yaa involves: BXSB * NZB MGI:3624970
ot29
X/Yaa (NZB x B6.SB/Le-Yaa)F1 MGI:4360217
ot30
X/Yaa (NZB x BXSB)F1 MGI:3624942
ot31
X/Yaa (NZW x BXSB)F1 MGI:3624975
ot32
X/Yaa (NZW x SB)F1 MGI:3624974
ot33
X/Yaa (SJL/J x BXSB)F1 MGI:3624943


Genotype
MGI:3836730
cx1
Allelic
Composition
Bxs6BXSB/MpJ/Bxs6BXSB/MpJ
X/Yaa
Genetic
Background
B10.BXSB-(D13Mit3-D13Mit78) Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bxs6BXSB/MpJ mutation (0 available); any Bxs6 mutation (0 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased levels of gp70 immune complex formation
• increased gp70 autoantibody titers
• increased glomerulonephritis incidence and severity
• decreased survival

hematopoietic system

renal/urinary system
• increased glomerulonephritis incidence and severity
• decreased survival

growth/size/body




Genotype
MGI:5488508
cx2
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tlr7tm1Flv/Y
X/Yaa
Genetic
Background
B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Tlr7tm1Flv mutation (1 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival is prolonged compared to mutant mice wild-type for Tlr7

immune system
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7
• autoantibodies show a homogeneous nuclear pattern
• develop a lupus like syndrome at a later age and in lower numbers compared to mutant mice wild-type for Tlr7
• increase in anti-RNA IgG levels in the serum at 4 - 6 months of age is less severe than in mutant mice wild-type for Tlr7 and is similar to mice homozygous for Fcgr2btm1Ttk alone

renal/urinary system
• kidney disease is less severe at 5 months of age compared to mutant mice wild-type for Tlr7

hematopoietic system
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7
• activation of splenocytes is reduced compared to mutant mice wild-type for Tlr7

growth/size/body
• less severe at 5 months of age compared to mutant mice wild-type for Tlr7




Genotype
MGI:5488509
cx3
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2btm1Ttk
X/Yaa
Genetic
Background
B6.Cg-Fcgr2btm1Ttk Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• moribund at 5 months of age

immune system
• autoantibodies show a nucleolar pattern
• marked increase in anti-RNA IgG levels in the serum at 4 - 6 months of age

renal/urinary system
• kidney disease

hematopoietic system

growth/size/body




Genotype
MGI:3804683
cx4
Allelic
Composition
Nba10NZB/Nba10NZB
Tlr7tm1Aki/Y
X/Yaa
Genetic
Background
B6.Cg-Nba10NZB Tlr7tm1Aki Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10NZB mutation (1 available); any Nba10 mutation (1 available)
Tlr7tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 20% monocytosis incidence in males
• monocytosis incidence is decreased compared to C57BL/6-Nba2NZB Yaa males (71% incidence)
• increased production of retroviral gp70 immune complex compared to wild-type males
• 25% incidence of lethal lupus nephritis in males by 14 months of age
• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males
• increased glomerular lesion score compared to wild-type males

renal/urinary system
• 25% incidence of lethal lupus nephritis in males by 14 months of age
• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males
• increased glomerular lesion score compared to wild-type males

hematopoietic system
• 20% monocytosis incidence in males
• monocytosis incidence is decreased compared to C57BL/6-Nba2NZB Yaa males (71% incidence)




Genotype
MGI:5488500
cx5
Allelic
Composition
Tlr7tm1Flv/Y
X/Yaa
Genetic
Background
B6.Cg-Tlr7tm1Flv Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7tm1Flv mutation (1 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• spleen marginal zone B cell numbers are similar to wild-type controls
• splenocyte proliferation in response to imiquimod is similar to controls




Genotype
MGI:3835838
cx6
Allelic
Composition
Il21rtm1Wjl/Il21rtm1Wjl
X/Yaa
Genetic
Background
BXSB.129(Cg)-Il21rtm1Wjl/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Wjl mutation (6 available); any Il21r mutation (42 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

mortality/aging
N
• the hypergammaglobulinemia, autoantibody production, reduced frequencies of marginal zone B cells and monocytosis, renal disease, and premature morbidity that are found in Yaa bearing mice with at least one wildtype copy of the interleukin 21 receptor are ameliorated or prevented by the disruption of the interleukin 21 receptor (J:144484)
• unlike IL21R heterozygous B2M null controls, these double homozygotes do not develop the Lupus-like autoimmune syndrome caused by Yaa and generally survive beyond 40 weeks of age (J:179430)




Genotype
MGI:6094201
cx7
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
X/Yaa
Genetic
Background
BXSB.129P2(B6)-B2mtm1Unc/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only 18 weeks
• despite the inability to generate serum IgG, there is increased anti-nuclear antibodies in the serum at 14 weeks of age, that is higher than that of BXSB/MpJ males with normal B2M expression

mortality/aging




Genotype
MGI:6094247
cx8
Allelic
Composition
H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
X/Yaa
Genetic
Background
BXSB.129P2(B6)-H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of MHC class I molecules intensifies the severity to a mean survival of only 25 weeks of age

mortality/aging




Genotype
MGI:6154363
cx9
Allelic
Composition
Tcratm1Mjo/Tcratm1Mjo
X/Yaa
Genetic
Background
BXSB.129P2(Cg)-Tcratm1Mjo/Theo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (101 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• due to the absense of alpha/beta T cells these Yaa-bearing males do not develop hypergammaglobulinemia, anti-chromatin auto-antibodies, enlarged lymph nodes or spleen, hemolytic anemia, immune complex glomerulonephritis, monocytosis, or the lupus-like autoimmune disease that normally causes premature death in Yaa-bearing males on the BXSB background, but instead these males are reported to live beyond 300 days




Genotype
MGI:6104236
cx10
Allelic
Composition
Cd8atm1Mak/Cd8atm1Mak
X/Yaa
Genetic
Background
BXSB.129S2(B6)-Cd8atm1Mak/4Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (39 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• compared with BXSB/MpJ males that carry Yaa, the additional ablation of CD8A accelerates the mortality from the spontaneous lupus erythematosus-like syndrome such that mortality occurs as early as 12 to 15 weeks of age and mean survival is only 20 weeks of age

mortality/aging




Genotype
MGI:6107168
cx11
Allelic
Composition
Ighmtm1Cgn/Ighmtm1Cgn
X/Yaa
Genetic
Background
BXSB.129S2(B6)-Ighmtm1Cgn/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• this null allele diminishes the B cells essential for the Yaa-induced development of Lupus-like autoimmune disease such that these males survive beyond 40 weeks, and do not have the increased splenic populations of CD4+ T cells or CD11b+ monocytes, nor is there elevated ICOS expression in splenic T cells




Genotype
MGI:6094248
cx12
Allelic
Composition
Tap1tm1Arp/Tap1tm1Arp
X/Yaa
Genetic
Background
BXSB.129S2(B6)-Tap1tm1Arp/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1tm1Arp mutation (4 available); any Tap1 mutation (51 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of Tap1 intensifies the severity to a mean survival of only 23 weeks of ag




Genotype
MGI:6094191
cx13
Allelic
Composition
Cd1d1tm1Luc/Cd1d1tm1Luc
X/Yaa
Genetic
Background
BXSB.129S6(B6)-Cd1d1tm1Luc/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation (2 available); any Cd1d1 mutation (35 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• disruption of Cd1d1 does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males




Genotype
MGI:6094246
cx14
Allelic
Composition
Fcgrttm1Dcr/Fcgrttm1Dcr
X/Yaa
Genetic
Background
BXSB.129X1-Fcgrttm1Dcr/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (23 available); any Fcgrt mutation (61 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• disruption of Fcgrt does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males




Genotype
MGI:6105930
cx15
Allelic
Composition
Il15tm1Imx/Il15tm1Imx
X/Yaa
Genetic
Background
BXSB.B6-Il15tm1Imx/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males also homozygous for this null allele of beta-2 microglobulin die much earlier, with a mean survival of only approximately 20 weeks

mortality/aging




Genotype
MGI:6105950
cx16
Allelic
Composition
Prf1tm1Sdz/Prf1tm1Sdz
X/Yaa
Genetic
Background
BXSB.B6-Prf1tm1Sdz/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prf1tm1Sdz mutation (13 available); any Prf1 mutation (52 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• death as a result of the Yaa-induced SLE-like autoimmunity is slightly increased in the early segment of the mortality curve relative to Yaa-bearing controls without the null allele

mortality/aging




Genotype
MGI:6105946
cx17
Allelic
Composition
Cd8atm1Mak/Cd8atm1Mak
Il15tm1Imx/Il15tm1Imx
X/Yaa
Genetic
Background
BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (39 available)
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• glomerular deposition of IgG at 14 weeks of age is more severe than that of BXSB/MpJ males

immune system
• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males homozygous for both null alleles die earlier than those with just one null allele and with a survival curve essentially the same as that of beta 2 microglobulin null Yaa carrying males, with a mean survival of only 18 weeks
• elevated over BXSB/MpJ males at 6 and 14 weeks of age

hematopoietic system
• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed




Genotype
MGI:3624981
cx18
Allelic
Composition
ll/ll
X/Yaa
Genetic
Background
BXSB/MpJScr-ll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ll mutation (0 available); any ll mutation (0 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous males have a mean life span of greater than 21 months, 3 to 4 time longer than non-homozygous males

endocrine/exocrine glands
• seen in about 20% of mice

immune system
• seen in about 20% of mice
• decrease in CD4+ T cells with age is less pronounced than in non-homozygous males
• do not develop severe monocytosis, unlike non-homozygous males
• at 3 to 5 months of age relative to non-homozygous males; however by 2 years of age IgG levels are similar to those in 2 to 3 month old early dying males
• minimal signs of autoimmune disease are seen at 8 months of age unlike non-homozygous males
• anti-nuclear antibodies are decreased relative to non-homozygous males

cardiovascular system
N
• no arteritic or degenerative vascular disease or myocardial infarctions are detected

neoplasm
• seen in about 20% of mice
• seen in about 20% of mice

renal/urinary system
N
• glomerular lesions characteristic of aging are seen at 28 months of age but homozygotes do not develop proliferative glomerulonephritis

hematopoietic system
• seen in about 20% of mice
• decrease in CD4+ T cells with age is less pronounced than in non-homozygous males
• do not develop severe monocytosis, unlike non-homozygous males
• at 3 to 5 months of age relative to non-homozygous males; however by 2 years of age IgG levels are similar to those in 2 to 3 month old early dying males




Genotype
MGI:3529942
cx19
Allelic
Composition
Nba10NZB/Nba10NZB
X/Yaa
Genetic
Background
C57BL/6-Nba2 Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10NZB mutation (1 available); any Nba10 mutation (1 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD11b+ monocyte numbers increase as mice age (J:129409)
• a Gr-1- monocyte subset is the dominant subset by 10 months of age (J:129409)
• increased susceptibility to monocytosis in males (J:137656)
• 71% monocytosis incidence in males (J:137656)
• increased serum gp70 immune complex levels
• increased production of serum gp70 immune complex in males
• increased anti-ribonucleoprotein production in males
• increased anti-chromatin and anti-DNA antibodies
• susceptibility to severe glomerulonephritis (J:95829)
• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)
• increased lupus nephritis score (severity) in males (J:137656)

renal/urinary system
• susceptibility to severe glomerulonephritis (J:95829)
• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)
• increased lupus nephritis score (severity) in males (J:137656)

hematopoietic system
• CD11b+ monocyte numbers increase as mice age (J:129409)
• a Gr-1- monocyte subset is the dominant subset by 10 months of age (J:129409)
• increased susceptibility to monocytosis in males (J:137656)
• 71% monocytosis incidence in males (J:137656)




Genotype
MGI:3812133
cx20
Allelic
Composition
Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa
Genetic
Background
EOD-Dsg4hage
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg4hage mutation (0 available); any Dsg4 mutation (86 available)
Faslpr mutation (39 available); any Fas mutation (82 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the mean life span of these male mice is 99 days, which is significantly longer than the 88 day mean lifespan that males from this strain normally live

growth/size/body
• mice are generally smaller than controls

immune system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice

hematopoietic system
• increased mast cell numbers are found in the superficial layer of the epidermis, with about a 3-fold increase over controls
• the characteristic B220+Thy1+ T cells population found in the spleen of mice carrying the Faslps allele is reduced by more than 5-fold in these mice

integument
• pups have scanty growth of short hair on the head and back
• the number of hair follicles in a given patch of skin appears to be higher than controls but counting is difficult because of the unusual orientation of the follicles
• axes of hair shafts are randomly oriented, with some being horizontal to the skin layer
• mice fail to grow vibrissae hairs
• mice have thick skin with hyperplasia of the epidermis that is prone to injury

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypotrichosis 6 DOID:0110703 OMIM:607903
J:140028




Genotype
MGI:4360218
cx21
Allelic
Composition
Fcgr2btm1Ttk/Fcgr2b+
X/Yaa
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 58% of mice display monocytosis by 10 months of age with a Gr-1- subset predominating

hematopoietic system
• 58% of mice display monocytosis by 10 months of age with a Gr-1- subset predominating




Genotype
MGI:5564926
cx22
Allelic
Composition
Btkm1Anu/Btkm1Anu
X/Yaa
Genetic
Background
involves: BXSB/MpJ * C57BL/6JAnu * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkm1Anu mutation (1 available); any Btk mutation (21 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in peripheral blood

immune system
• in peripheral blood




Genotype
MGI:5427950
cx23
Allelic
Composition
Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
Genetic
Background
involves: C57BL/6 * FVB/N * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (49 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit greater cumulative death compared with Fcgr2btm1.2Sjv homozygotes

immune system
• compared with Fcgr2btm1.2Sjv homozygotes
• compared with single homozygotes
• mice develop moderate lupus unlike Fcgr2btm1.2Sjv homozygotes
• however, mice do not develop fatal lupus
• compared with single homozygotes
• compared with single homozygotes

renal/urinary system
• kidney pathology is increased compared to in Fcgr2btm1.2Sjv homozygotes

hematopoietic system
• compared with Fcgr2btm1.2Sjv homozygotes
• compared with single homozygotes

growth/size/body
• compared with Fcgr2btm1.2Sjv homozygotes




Genotype
MGI:5488504
ot24
Allelic
Composition
X/Yaa
Genetic
Background
B6.SB-Yaa/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• hyperresponsive to imiquimod induced splenocyte proliferation

hematopoietic system
• hyperresponsive to imiquimod induced splenocyte proliferation

cellular
• hyperresponsive to imiquimod induced splenocyte proliferation




Genotype
MGI:3624973
ot25
Allelic
Composition
X/Yaa
Genetic
Background
BXSB/MpJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean longevity for males is 155 +/- 13 days compared to 442 +/- 29 days for littermate females (J:6235)
• castration does not significantly alter longevity (J:6235)
• median survival is 8 months (J:7308)

immune system
• 4-fold increase in spleen weight
• frequency of C3d receptor bearing cells is increased in young mice but declines with age
• increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females
• frequency of Ig-bearing cells is increased in the thymus
• at 14 weeks of age, more than normal splenic CD4+ Foxp3+ CD25+ T cells and very few splenic CD8+ Foxp3+ CD25+ T cells and higher than normal expression of CD122 on CD8+ splenic T cells
• increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age
• at 8 months of age a 16-fold increase in monocytes is seen in males compared to females
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
• relative to BXSB.B6-Yaa+ at 14 weeks of age but not at 6 weeks of age
(J:93740)
(J:179430)
• relative to BXSB.B6-Yaa+ controls
• relative to BXSB.B6-Yaa+ controls
• infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node
• moderately enlarged
• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• accelerated autoimmune syndrome relative to females of the same strain (J:6235)
(J:108760)
• erythrocyte autoantibodies were found in 7 of 13 males between 16 and 25 weeks of age
• serum anti-nuclear antibodies are found at 6 weeks of age and increased levels at 14 weeks of age
• acute to subacute exudative and proliferative glomerulonephritis

hematopoietic system
• 4-fold increase in spleen weight
• frequency of C3d receptor bearing cells is increased in young mice but declines with age
• decreased at 16 weeks of age compared to C57BL/6J males
• increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females
• frequency of Ig-bearing cells is increased in the thymus
• at 14 weeks of age, more than normal splenic CD4+ Foxp3+ CD25+ T cells and very few splenic CD8+ Foxp3+ CD25+ T cells and higher than normal expression of CD122 on CD8+ splenic T cells
• increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age
• at 8 months of age a 16-fold increase in monocytes is seen in males compared to females
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
• relative to BXSB.B6-Yaa+ at 14 weeks of age but not at 6 weeks of age
(J:93740)
(J:179430)
• relative to BXSB.B6-Yaa+ controls
• relative to BXSB.B6-Yaa+ controls

renal/urinary system
• seen at 4 months of age
• acute to subacute exudative and proliferative glomerulonephritis
• glomerular depositions of IgG are found at 14 weeks of age

homeostasis/metabolism
• seen at 4 months of age

growth/size/body
• 4-fold increase in spleen weight




Genotype
MGI:3624982
ot26
Allelic
Composition
X/Yaa
Genetic
Background
BXSB/MpJScr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
• pronounced decrease in CD4+ T cells with age
• accelerated autoimmune syndrome
• anti-nuclear antibody levels are elevated at 3 to 5 months of age
• develop severe proliferative glomerulonephritis by 3 to 5 months of age

hematopoietic system
• pronounced decrease in CD4+ T cells with age

renal/urinary system
• develop severe proliferative glomerulonephritis by 3 to 5 months of age




Genotype
MGI:3624944
ot27
Allelic
Composition
X/Yaa
Genetic
Background
(C57BL/6J x BXSB)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean longevity for males is 332 +/- 14 days compared to 716 +/- 28 days for littermate females

immune system
• moderately enlarged
• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• accelerated autoimmune syndrome relative to reciprocal hybrid males




Genotype
MGI:3624970
ot28
Allelic
Composition
X/Yaa
Genetic
Background
involves: BXSB * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean longevity for males is 352 +/- 35 days while males with a wild-type Yaa allele survive 2.5 times longer

immune system
• moderately enlarged
• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• accelerated autoimmune syndrome relative to males with a wild-type Yaa allele




Genotype
MGI:4360217
ot29
Allelic
Composition
X/Yaa
Genetic
Background
(NZB x B6.SB/Le-Yaa)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD11b+ monocyte numbers increase as mice age with a 3-fold increase by 10 months of age

hematopoietic system
• CD11b+ monocyte numbers increase as mice age with a 3-fold increase by 10 months of age




Genotype
MGI:3624942
ot30
Allelic
Composition
X/Yaa
Genetic
Background
(NZB x BXSB)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean longevity for males is 166 +/- 6 days compared to 545 +/- 37 days for reciprocal hybrid males

immune system
• 20-fold increase in spleen weight by 20 weeks of age
• infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node
• enlarged 13-fold at 18 to 20 weeks of age compared to reciprocal hybrid males and 6 fold compared to BXSB males
• spleen cell responses to phytohemagglutinin and concanavalin A are reduced and response to E. coli lipopolysaccharide is increased
• however, lymph node cell response to concanavalin A is similar to reciprocal hybrid males
• at 4 weeks of age, in vitro proliferation of spleen cells is increased 3-fold compared to cells from reciprocal hybrid males
• accelerated autoimmune syndrome relative to reciprocal hybrid males
• high titers of thymotoxic autoantibodies were found between 16 and 20 weeks of age in 15 of 16 males
• erythrocyte autoantibodies were found in 16 of 17 males between 16 and 20 weeks of age
• high titers of antinuclear antibody were found between 16 and 20 weeks of age in 14 of 16 males

homeostasis/metabolism
• at 23 weeks of age protoporphyrin levels are 543 +/- 368 mg/100 ml packed erythrocytes compared to 39 +/- 1 mg in reciprocal hybrid males

hematopoietic system
• 20-fold increase in spleen weight by 20 weeks of age

growth/size/body
• 20-fold increase in spleen weight by 20 weeks of age




Genotype
MGI:3624975
ot31
Allelic
Composition
X/Yaa
Genetic
Background
(NZW x BXSB)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% mortality is seen at 4.5 months of age compared to 16 months in reciprocal hybrid males

immune system
• gp70 immune complexes are detectable earlier and reach higher concentrations compared to reciprocal hybrid males; however, the total concentration of free and complexed gp70 is similar
• accelerated autoimmune syndrome relative to reciprocal hybrid males




Genotype
MGI:3624974
ot32
Allelic
Composition
X/Yaa
Genetic
Background
(NZW x SB)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% and 90% mortality are seen at 4.5 and 8 months of age, respectively, compared to 50% mortality at 15 months in reciprocal hybrid males

immune system
• gp70 immune complexes are detectable earlier and reach higher concentrations compared to reciprocal hybrid males
• accelerated autoimmune syndrome relative to reciprocal hybrid males

renal/urinary system




Genotype
MGI:3624943
ot33
Allelic
Composition
X/Yaa
Genetic
Background
(SJL/J x BXSB)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yaa mutation (24 available); any Yaa mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean longevity for males is 308 +/- 26 days while only 8 of 16 reciprocal hybrid males died between 270 and 684 days

immune system
• moderately enlarged
• at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• accelerated autoimmune syndrome relative to reciprocal hybrid males





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory