Phenotypes associated with this allele

• Allele Symbol: Gli3^add
• Allele Name: anterior digit pattern deformity
• Allele ID: MGI:1856280
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli3^add/Gli3^add	involves: C57BL/6 * SJL	MGI:3823093
ht2	Gli3^add/Gli3^Xt	involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL	MGI:3823094

Genotype
MGI:3823093

hm1

• Allelic Composition: Gli3^add/Gli3^add
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit development ( J:11318 )

• thumb shows irregular growth on forepaw ranging from slight change in architecture to elongation of thumb by almost 100%

• when thumb is elongated to certain extent, digit 2 becomes bent and connected to thumb via soft tissue

• thumb phenotype is obvious at day 14 of development

• about 10% of forelimbs examined display an additional phalanx on digit 2

• bone fusion of thumb and digit 2 is never observed

Genotype
MGI:3823094

ht2

• Allelic Composition: Gli3^add/Gli3^Xt
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL

limbs/digits/tail

polydactyly ( J:11318 )

• on 50% of animals, seven digits are observed on fore- and hindlimbs

• when double mutants are backcrossed to wild-type (C57BL/6 x SJL)F1 animals, 50% of mice display only 1 extra toe per hindlimb

abnormal digit development ( J:11318 )

• in some animals 2 of the extra digits are fused