Phenotypes associated with this allele

• Allele Symbol: Del(7)Tyr^c-6H
• Allele Name: deletion, Chr 7, albino 6 Harwell
• Allele ID: MGI:1856305
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7)Tyr^c-6H/Del(7)Tyr^c-6H	involves: 101/H * C3H/HeH	MGI:4843146
cx2	Tyr^c-ch/Del(7)Tyr^c-6H	involves: 101/H * C3H/HeH	MGI:4843178
cx3	Del(7)Tyr^c-3H/Del(7)Tyr^c-6H	involves: 101/H * C3H/HeH	MGI:5638543

Genotype
MGI:4843146

hm1

• Allelic Composition: Del(7)Tyr^c-6H/Del(7)Tyr^c-6H
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:5741 )

• mutant embryos are first identified at E6.5-E7 by ectoplacental cone and parietal endoderm abnormalities

• at E7.5 embryos are severely retarded with obvious abnormalities seen in all germ layers

• all mice are dead and resorbed by E8

embryo

abnormal egg cylinder morphology ( J:5741 )

• normal differentiation of extra-embryonic ectoderm does not occur

Genotype
MGI:4843178

cx2

• Allelic Composition: Tyr^c-ch/Del(7)Tyr^c-6H
• Genetic Background: involves: 101/H * C3H/HeH

pigmentation

abnormal coat/hair pigmentation ( J:5741 )

diluted coat color ( J:5741 )

• these mice are noticeably lighter in color than mice that are homozygous chinchilla

integument

abnormal coat/hair pigmentation ( J:5741 )

diluted coat color ( J:5741 )

• these mice are noticeably lighter in color than mice that are homozygous chinchilla

Genotype
MGI:5638543

cx3

• Allelic Composition: Del(7)Tyr^c-3H/Del(7)Tyr^c-6H
• Genetic Background: involves: 101/H * C3H/HeH

cellular

abnormal male germ cell morphology ( J:6034 )

♂

abnormal sperm nucleus morphology ( J:6034 )

♂ • at stage 13 abnormalities of sperm head condensation are seen

maternal effect ( J:6034 )

♀ • females with this genotype are unable to produce live offspring

growth/size/body

decreased body size ( J:6034 )

• mice of this genotype are runted

reproductive system

abnormal gametogenesis ( J:6034 )

♂

abnormal male germ cell morphology ( J:6034 )

♂

abnormal sperm nucleus morphology ( J:6034 )

♂ • at stage 13 abnormalities of sperm head condensation are seen

abnormal spermiogenesis ( J:6034 )

♂ • abnormal head condensation at stage 13

female infertility ( J:6034 )

♀ • complete gestational failure due to mother's genotype

male infertility ( J:6034 )

♂ • due to abnormal spermiogenesis

mortality/aging

prenatal lethality, complete penetrance ( J:6034 )

• the majority of embryos are resorbed between E10-E14 and show no gross abnormalities

• complete gestational failure due to mother's genotype