All Phenotypes Dmd<mdx-2Cv> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dmd^mdx-2Cv
X linked muscular dystrophy 2, Verne Chapman
MGI:1856329

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmd^mdx-2Cv/Dmd^mdx-2Cv	B6Ros.Cg-Dmd^mdx-2Cv	MGI:3798614
ot2	Dmd^mdx-2Cv/Y	B6Ros.Cg-Dmd^mdx-2Cv	MGI:3798615
ot3	Dmd^mdx-2Cv/Y	B6Ros.Cg-Dmd^mdx-2Cv/J	MGI:3798630
ot4	Dmd^mdx-2Cv/Y	involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m. musculus	MGI:3798605

Allelic Composition	Dmd^mdx-2Cv/Dmd^mdx-2Cv
Genetic Background	B6Ros.Cg-Dmd^mdx-2Cv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-2Cv mutation (1 available); any Dmd mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal diaphragm morphology ( J:23502 )

• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age

skeletal muscle fibrosis ( J:23502 )

• mice exhibit progressive fibrosis of the diaphragm with age, unlike in wild-type mice

Allelic Composition	Dmd^mdx-2Cv/Y
Genetic Background	B6Ros.Cg-Dmd^mdx-2Cv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-2Cv mutation (1 available); any Dmd mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal diaphragm morphology ( J:23502 )

• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age

skeletal muscle fibrosis ( J:23502 )

• mice exhibit progressive fibrosis of the diaphragm with age, unlike in wild-type mice

Allelic Composition	Dmd^mdx-2Cv/Y
Genetic Background	B6Ros.Cg-Dmd^mdx-2Cv/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-2Cv mutation (1 available); any Dmd mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:53822 )

• derived positive (P2) responses are delayed compared to in wild-type mice

Allelic Composition	Dmd^mdx-2Cv/Y
Genetic Background	involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx-2Cv mutation (1 available); any Dmd mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

• mice exhibit skeletal muscle fiber degeneration, regeneration and sometimes fibrosis

skeletal muscle fiber degeneration ( J:9638 )

• mice exhibit skeletal muscle fiber degeneration, regeneration and sometimes fibrosis

impaired muscle relaxation ( J:9638 )

• electromyograms reveal peudomyotonia unlike in wild-type mice

cardiovascular system

cardiac fibrosis ( J:9638 )

• unlike wild-type, minimal to focal cardiac fibrosis is observed

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