Analysis Tools
mortality/aging
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• mice do not survive longer than 24 days of age
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behavior/neurological
nervous system
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• cells have pycnotic nuclei and may be vacuolated
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astrocytosis
(
J:36181
)
|
|
|
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• there is a sharp reduction in oligodendrocyte number
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• the few myelin sheaths are in early myelinating areas, formed in clusters of thin loosely wrapped membranes
(J:36181)
• the hypomyelination is the most severe of any of the spontaneously occurring myelin mutations
(J:41569)
• virtual absence of associated proteolipid protein
(J:41569)
|
