Phenotypes associated with this allele

• Allele Symbol: Wnt1^sw
• Allele Name: swaying
• Allele ID: MGI:1856382
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt1^sw/Wnt1^sw	B6C3Fe a/a-Wnt1^sw/J	MGI:3698851
hm2	Wnt1^sw/Wnt1^sw	involves: B6C3Fe * C57BL/6J	MGI:5441595
hm3	Wnt1^sw/Wnt1^sw	Not Specified	MGI:4365745

Genotype
MGI:3698851

hm1

• Allelic Composition: Wnt1^sw/Wnt1^sw
• Genetic Background: B6C3Fe a/a-Wnt1^sw/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

reduced linear vestibular evoked potential ( J:116914 )

• elevated threshold and absent central response peaks

Genotype
MGI:5441595

hm2

• Allelic Composition: Wnt1^sw/Wnt1^sw
• Genetic Background: involves: B6C3Fe * C57BL/6J

nervous system

absent midbrain-hindbrain boundary ( J:29060 )

• the boundary between mesencephalon and metencephalon does not form

Genotype
MGI:4365745

hm3

• Allelic Composition: Wnt1^sw/Wnt1^sw
• Genetic Background: Not Specified

behavior/neurological

abnormal posture ( J:15063 )

• affecte mice never stand normally

abnormal locomotor coordination ( J:15063 )

ataxia ( J:30722 )

impaired swimming ( J:15063 )

abnormal gait ( J:15063 )

• affected mice never walk directly forward

• affected mice sway from side-to-side whenever attempting to move forward and lean against the side of the pen for support

• change of direction involves a clockwise or counterclockwise pivot around the rear legs and mice may roll

weaving ( J:15063 )

muscle

muscle hypertonia ( J:30722 )

• of limbs

nervous system

abnormal cerebellum development ( J:1970 , J:30722 )

• affected mice retain the sagittal grooves that separate the hemispheres before 15-16 days of embryonic development (J:1970)

• there is failure of cerebellar hemisphere midline fusion (J:1970)

• affects the midline parts of the cerebellum (J:30722)

abnormal brain white matter morphology ( J:30722 )

• white matter is fused directly with the superior colliculi; no meningeal tissue separates them

abnormal inferior colliculus morphology ( J:30722 )

• lateral displacement of this structure

abnormal cerebellar cortex morphology ( J:30722 )

• at least by birth cortical tissue is broken into irregular islands of cells crossed by aberrant fascicles of white matter

• despite gross morphology individual cell types are relatively normal

abnormal cerebellum anterior vermis morphology ( J:30722 )

• loss of the most anterior parts