All Phenotypes Egfr<tm1Mag> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egfr^tm1Mag/Egfr^tm1Mag	involves: 129S2/SvPas * CD-1	MGI:2175844
hm2	Egfr^tm1Mag/Egfr^tm1Mag	involves: 129S2/SvPas * CF-1	MGI:2175842
hm3	Egfr^tm1Mag/Egfr^tm1Mag	involves: 129/Sv * 129S2/SvPas	MGI:2175843
ht4	Egfr^tm1Dwt/Egfr^tm1Mag	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J	MGI:3834094
ht5	Egfr^tm1Mag/Egfr^wa2	involves: 129S2/SvPas * B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt * CD-1	MGI:2176562
cn6	Chuk^tm1Yhu/Chuk^tm1Yhu Egfr^tm1Mag/Egfr^tm1Mag Tg(KRT5-cre)5132Jlj/0	involves: 129 * C57BL/6 * CD-1	MGI:3817622
cn7	Chuk^tm1Yhu/Chuk^tm1Yhu Egfr^tm1Mag/Egfr⁺ Tg(KRT5-cre)5132Jlj/0	involves: 129 * C57BL/6 * CD-1	MGI:3817623

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:26833 )

• on a CD-1-enriched genetic background, homozygotes die perinatally; however, survival can be extended up to P18 upon removal of wild-type littermates

growth/size/body

abnormal tongue morphology ( J:26833 )

• mutant tongues contain reduced interspersed adipose tissue

abnormal filiform papillae morphology ( J:26833 )

• homozygotes display abnormal filiform papillae with reduced connective tissue

abnormal fungiform papillae morphology ( J:26833 )

• homozygotes show a reduction in the number of fungiform papillae

• those present at P12 appear disorganized and lack identifiable taste buds

cachexia ( J:26833 )

• homozygous mutant pups exhibit progressive wasting; postnatal survivors are only 30-35% the weight of wild-type littermates

postnatal growth retardation ( J:26833 )

• homozygous mutant pups exhibit a 15% reduction in postnatal growth, despite normal birth weights

vision/eye

absent eyelids ( J:26833 )

• at E14.5-E18.5, homozygotes fail to form eyelids

eyelids open at birth ( J:26833 )

• homozygotes have open eyes at birth

digestive/alimentary system

abnormal tongue morphology ( J:26833 )

• mutant tongues contain reduced interspersed adipose tissue

abnormal filiform papillae morphology ( J:26833 )

• homozygotes display abnormal filiform papillae with reduced connective tissue

abnormal fungiform papillae morphology ( J:26833 )

• homozygotes show a reduction in the number of fungiform papillae

• those present at P12 appear disorganized and lack identifiable taste buds

abnormal esophageal epithelium morphology ( J:26833 )

• at P12 and P18, homozygotes display decreased BrdU labeling in the basal layer of the esophagus

abnormal colon morphology ( J:26833 )

• although normal through P12, the mutant colonic epithelium displays an aberrant glandular architecture by P18

• at P18, tall disorganized branching crypt columns are occasionally found close to short rudimentary crypt columns

liver/biliary system

abnormal liver morphology ( J:26833 )

• although normal at E17.5, mutant livers show aberrant sinusoidal anatomy and abnormal vacuolizatized nuclei by P8

abnormal hepatocyte morphology ( J:26833 )

• by P8, mutant livers display thickened hepatocyte cords

renal/urinary system

dilated kidney collecting duct ( J:26833 )

• homozygotes exhibit cystic dilation of collecting tubules, with a flattened instead of a cuboidal epithelial lining

homeostasis/metabolism

increased circulating creatinine level ( J:26833 )

• at P18, homozygotes display increased serum creatinine levels relative to wild-type littermates (2.4 mg/dl vs 0.1 mg/dl, respectively)

increased blood urea nitrogen level ( J:26833 )

• at P12, homozygotes display 75 mg/dl BUN vs 26 mg/dl in wild-type littermates; BUN reaches 288 mg/dl at P18

nervous system

abnormal cerebellum external granule cell layer morphology ( J:26833 )

• after birth, homozygotes exhibit delayed migration of the EGC layer

decreased brain size ( J:26833 )

• at E18.5, homozygotes display a reduction in overall brain size; cortical regions are most affected

abnormal cerebral cortex morphology ( J:26833 )

• at E18.5, the mutant cerebral cortex appears relatively normal; however, neuroblast migration and cortical plate formation is impaired

• at E18.5, the mutant ventricular zone is thickened while the intermediate zone is markedly thinned in some mutants

thin cerebral cortex ( J:26833 )

• by P18, homozygotes display atrophy of the anterior cerebral cortex, which is reduced to a thin sheet of cells

abnormal olfactory bulb morphology ( J:26833 )

• at E18.5, mutant olfactory bulbs appear normal in size and cell composition; however, by P14, mitral and tufted cells are nearly absent

• at P18, homozygotes show a shorter or absent molecular layer; in contrast, glomerular structures remain unaffected

decreased Purkinje cell number ( J:26833 )

• at E18.5 and postnatally, the mutant cerebellar plate contains fewer Purkinje cells

small cerebellum ( J:26833 )

respiratory system

abnormal lung development ( J:26833 )

• at E18.5, 2 of 8 homozygotes show slightly immature lung histology and weaker surfactant staining possibly due to overall growth retardation

craniofacial

abnormal tongue morphology ( J:26833 )

• mutant tongues contain reduced interspersed adipose tissue

abnormal filiform papillae morphology ( J:26833 )

• homozygotes display abnormal filiform papillae with reduced connective tissue

abnormal fungiform papillae morphology ( J:26833 )

• homozygotes show a reduction in the number of fungiform papillae

• those present at P12 appear disorganized and lack identifiable taste buds

integument

abnormal coat appearance ( J:26833 )

• homozygotes have a fuzzy coat

delayed hair appearance ( J:26833 )

• homozygotes exhibit a delay in the appearance of emerging hair

abnormal hair shaft morphology ( J:26833 )

• by P5, the mutant hair shaft shows premature separation from the inner root sheath

abnormal hair follicle development ( J:26833 )

• by P2, homozygotes show a decline in interfollicular epidermal proliferation, reaching only 38% of the wild-type labeling index at P8

abnormal hair follicle inner root sheath morphology ( J:26833 )

• by P5, the mutant inner root sheath display premature hair keratinization and maturation

abnormal hair follicle orientation ( J:26833 )

• by P5, mutant hair follicles appear disoriented

distorted hair follicle pattern ( J:26833 )

• by P5, mutant hair follicles are abnormally placed

curly vibrissae ( J:26833 )

• mutant whiskers are fragile and appear to curl anteriorly

wavy vibrissae ( J:26833 )

• homozygous mutant pups display rudimentary waved whiskers

Allelic Composition	Egfr^tm1Mag/Egfr^tm1Mag
Genetic Background	involves: 129S2/SvPas * CF-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Mag mutation (1 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:26833 )

• on a CF1-enriched genetic background, homozygotes die before E7.5; only 2% of homozygotes are obtained at E6.5

embryo

abnormal inner cell mass morphology ( J:26833 )

• at E4.5-E4.8, 6 of 32 homozygotes exhibit small, loosely arranged inner cell masses with no distinct endoderm

• at E5.1-E5.5, 13 of 61 mutant embryos are collapsed; by E6.5, 8 of 31 decidua lack an embryo and are filled with maternal blood

Allelic Composition	Egfr^tm1Mag/Egfr^tm1Mag
Genetic Background	involves: 129/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Mag mutation (1 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:26833 )

• Background Sensitivity: homozygotes exhibit perinatal lethality on a CD-1 background

embryonic lethality during organogenesis, complete penetrance ( J:26833 )

• on a 129/Sv-enriched genetic background, homozygotes die at midgestation with resorbing embryos evident at E12.5-E13.5

embryonic lethality at implantation, complete penetrance ( J:26833 )

• Background Sensitivity: homozygotes exhibit peri-implantation lethality on a CF1 background

embryo

decreased trophoblast giant cell number ( J:26833 )

• at E12.5-E13.5, the labyrinthine trophoblast cell number is reduced

decreased spongiotrophoblast size ( J:26833 )

• at E12.5-E13.5, the mutant spongiotrophoblast is significantly reduced

abnormal placenta labyrinth morphology ( J:26833 )

• at E12.5-E13.5, the labyrinthine trophoblast appears disorganized and hypoplastic

• in contrast, the organization and cell number of the trophoblast giant-cell layer is unremarkable

small placenta ( J:26833 )

• at E12.5-E13.5, mutant placentas are smaller than wild-type

Allelic Composition	Egfr^tm1Dwt/Egfr^tm1Mag
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Dwt mutation (1 available); any Egfr mutation (87 available)
Egfr^tm1Mag mutation (1 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:145161 )

N	• mice are fertile

growth/size/body

growth/size/body region phenotype ( J:145161 )

N	• mice exhibit normal body weight

integument

integument phenotype ( J:145161 )

N	• mice exhibit normal coat color

Allelic Composition	Egfr^tm1Mag/Egfr^wa2
Genetic Background	involves: 129S2/SvPas * B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^tm1Mag mutation (1 available); any Egfr mutation (87 available)
Egfr^wa2 mutation (3 available); any Egfr mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thick aortic valve ( J:60750 )

• thickened aortic valves

Allelic Composition	Chuk^tm1Yhu/Chuk^tm1Yhu Egfr^tm1Mag/Egfr^tm1Mag Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129 * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Yhu mutation (0 available); any Chuk mutation (51 available)
Egfr^tm1Mag mutation (1 available); any Egfr mutation (87 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:141162 )

• mice die 3 days after birth

Allelic Composition	Chuk^tm1Yhu/Chuk^tm1Yhu Egfr^tm1Mag/Egfr⁺ Tg(KRT5-cre)5132Jlj/0
Genetic Background	involves: 129 * C57BL/6 * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:141162 )

• most mice die but some survive

premature death ( J:141162 )

• most mice die but some survive

vision/eye

abnormal eye morphology ( J:141162 )

• mice exhibit eye defects

integument

abnormal coat/ hair morphology ( J:141162 )

• mice exhibit hair defects

thick epidermis ( J:141162 )

• slightly

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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