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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mafbkr
kreisler
MGI:1856419
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mafbkr/Mafbkr CBA.Cg-Mafbkr MGI:4830456
hm2
 		Mafbkr/Mafbkr involves: C3H/HeJ * C57BL/6J * CBA/CaJ MGI:4830348
hm3
 		Mafbkr/Mafbkr Not Specified MGI:2169746


Genotype
MGI:4830456
hm1
Allelic
Composition		 Mafbkr/Mafbkr
Genetic
Background		 CBA.Cg-Mafbkr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbkr mutation (2 available); any Mafb mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
inner ear cyst ( J:5392 )
• mice with cysts also have have rudimentary semicircular canals
abnormal otic vesicle development ( J:5392 )
• the expected flattening of the caudolateral wall is not seen at E11
abnormal semicircular canal morphology ( J:5392 )
• the majority of mutant mice have rudimentary canals and also cysts although the condition may not be bilateral
abnormal endolymphatic duct morphology ( J:5392 )
• a large endolymphatic space unassociated with a stria vascularis or an endolymphatic duct and sac is seen in mature mutant mice
absent endolymphatic duct ( J:5392 )
• at E12 otic vesicles of mutant mice lacked an endolymphatic duct

cellular
abnormal cell cycle ( J:5392 )
• at E11 the cell cycle time of a developing otocyst is shorter than that seen in a heterozygous littermate or a CBA/J mouse
abnormal cell cycle checkpoint function ( J:5392 )
• at E11 the premitotic phase of a developing otocyst is longer than seen in a heterozygous littermate or CBA/J mouse

growth/size/body
inner ear cyst ( J:5392 )
• mice with cysts also have have rudimentary semicircular canals




Genotype
MGI:4830348
hm2
Allelic
Composition		 Mafbkr/Mafbkr
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbkr mutation (2 available); any Mafb mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal hyoid bone greater horn morphology ( J:4596 )
• ectopic development of a second arch structure, a hyoid lesser horn, in an area normally derived from the third arch results in an accessory process
ectopic bone ( J:4596 )
• an accessory process is seen on the greater horn of the hyoid bone

craniofacial
abnormal hyoid bone greater horn morphology ( J:4596 )
• ectopic development of a second arch structure, a hyoid lesser horn, in an area normally derived from the third arch results in an accessory process
ectopic pharyngeal arch ( J:4596 )
• a second arch anlange develops in an area normally derived from a third arch resulting in an accessory process on the greater horn of the hyoid bone

embryo
ectopic pharyngeal arch ( J:4596 )
• a second arch anlange develops in an area normally derived from a third arch resulting in an accessory process on the greater horn of the hyoid bone
abnormal pharyngeal arch development ( J:4596 )
• the third arch structure does not develop
abnormal rhombomere morphology ( J:4596 )
• segmentation does not occur caudally from the boundary between rhombomeres 3 and 4
• two rhombomeres do not develop resulting in ectopic structure development

nervous system
abnormal rhombomere morphology ( J:4596 )
• segmentation does not occur caudally from the boundary between rhombomeres 3 and 4
• two rhombomeres do not develop resulting in ectopic structure development




Genotype
MGI:2169746
hm3
Allelic
Composition		 Mafbkr/Mafbkr
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbkr mutation (2 available); any Mafb mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
abnormal otic vesicle development ( J:13001 , J:15032 )
• at E9 the otic vesicle is in an abnormal position, likely due to abnormal neural tube development (J:13001)
• an imperfect capsule forms around the vesicle (J:13001)
abnormal inner ear morphology ( J:13001 )
• the adult ear mainly comprises a large sac containing endolymphatic and perilymphatic spaces
inner ear cyst ( J:15032 )
• extracapsular cysts grow through gaps in the otic capsule become quite large and locate under the brain
abnormal otic capsule development ( J:13001 )
• the capsule is not continuous allowing extracapsular cysts to grow into the otic vesicle
abnormal cochlear sensory epithelium morphology ( J:13001 )
• only occasional areas of sensory epithelium are noted

reproductive system
reduced male fertility ( J:15032 )
• males are more likely to breed than females

embryo
abnormal neural tube morphology ( J:1490 , J:13001 )
• at E9.5 the neural tube posterior to the boundary between rhombomeres 3 and 4 appears unsegmented (J:1490)
• abnormal segmentation of the neural tube in the region of the rhombencephalon is seen in E8.75 embryos (J:13001)
abnormal rhombomere 4 morphology ( J:1490 , J:13001 )
• at E9.5 the region normally corresponding to rhombomere 4 is unusually thick-walled and contains many dying cells (J:1490)
• extensive cell degeneration occurs in the fourth rhombomere after E8 (J:13001)
abnormal rhombomere 5 morphology ( J:1490 )
• at E9.5 the region normally corresponding to rhombomere 5 is unusually thick-walled and contains many dying cells

nervous system
abnormal neural tube morphology ( J:1490 , J:13001 )
• at E9.5 the neural tube posterior to the boundary between rhombomeres 3 and 4 appears unsegmented (J:1490)
• abnormal segmentation of the neural tube in the region of the rhombencephalon is seen in E8.75 embryos (J:13001)
abnormal rhombomere 4 morphology ( J:1490 , J:13001 )
• at E9.5 the region normally corresponding to rhombomere 4 is unusually thick-walled and contains many dying cells (J:1490)
• extensive cell degeneration occurs in the fourth rhombomere after E8 (J:13001)
abnormal rhombomere 5 morphology ( J:1490 )
• at E9.5 the region normally corresponding to rhombomere 5 is unusually thick-walled and contains many dying cells

craniofacial

growth/size/body
inner ear cyst ( J:15032 )
• extracapsular cysts grow through gaps in the otic capsule become quite large and locate under the brain

skeleton




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory