Phenotypes associated with this allele

• Allele Symbol: Pmp22^Tr-Ncnp
• Allele Name: trembler National Center of Neurology and Psychiatry
• Allele ID: MGI:1856420
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmp22^Tr-Ncnp/Pmp22^Tr-Ncnp	GAD/Ncnp-Pmp22^Tr-Ncnp	MGI:3794532
ht2	Pmp22^Tr-Ncnp/Pmp22^+	GAD/Ncnp-Pmp22^Tr-Ncnp	MGI:3794531

Genotype
MGI:3794532

hm1

• Allelic Composition: Pmp22^Tr-Ncnp/Pmp22^Tr-Ncnp
• Genetic Background: GAD/Ncnp-Pmp22^Tr-Ncnp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Schwann cell morphology ( J:43874 )

• some pyknotic Schwann cells are observed

abnormal myelination ( J:43874 )

• at P9, 1 month and 5 months of age, no myelination is observed on the sciatic nerves unlike in wild-type mice

• axonal development is stalled at the promyelin stage

behavior/neurological

abnormal gait ( J:43874 )

• gait abnormalities progress slightly with age

Genotype
MGI:3794531

ht2

• Allelic Composition: Pmp22^Tr-Ncnp/Pmp22⁺
• Genetic Background: GAD/Ncnp-Pmp22^Tr-Ncnp

nervous system

demyelination ( J:43874 )

• peripheral nerves in the hind- and forelimbs are hypomyelination

behavior/neurological

abnormal gait ( J:43874 )

• gait abnormalities progress slightly with age