Phenotypes associated with this allele

• Allele Symbol: Hmga2^pg
• Allele Name: pygmy
• Allele ID: MGI:1856426
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmga2^pg/Hmga2^pg	involves: A/St * C57BL * MacArthur's small stock	MGI:3805686
hm2	Hmga2^pg/Hmga2^pg	involves: MacArthur's small stock	MGI:3805681

Genotype
MGI:3805686

hm1

• Allelic Composition: Hmga2^pg/Hmga2^pg
• Genetic Background: involves: A/St * C57BL * MacArthur's small stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

small ears ( J:13064 )

• at 4 days of age the pinna of pygmy mice are smaller compared to normal mice

• by 12 days of age the ear size differential is pronounced

abnormal postnatal growth/weight/body size ( J:13064 )

decreased body size ( J:13064 )

• markedly smaller than normal at birth

decreased body weight ( J:13064 )

• adults weigh about one-third as much as normal mice

slow postnatal weight gain ( J:13064 )

• negligible increase in weight from 12-21 days due to competition with normal siblings for milk

postnatal growth retardation ( J:13064 )

• the course of growth is normal but growth rate is reduced

craniofacial

small ears ( J:13064 )

• at 4 days of age the pinna of pygmy mice are smaller compared to normal mice

• by 12 days of age the ear size differential is pronounced

reproductive system

small ovary ( J:13064 )

♀ • ovaries are small in proportion to body size

♀ • follicle development is evident

small testis ( J:13064 )

♂

cryptorchism ( J:13064 )

♂ • common among males

small uterus ( J:13064 )

♀ • the uterus is small in proportion to body size

priapism ( J:13064 )

♂ • develops in the majority of males by six weeks of age

♂ • not correlated with testes descent

abnormal estrous cycle ( J:13064 )

♀ • females have an irregular estrous cycle

female infertility ( J:13064 )

♀

male infertility ( J:13064 )

♂

endocrine/exocrine glands

small ovary ( J:13064 )

♀ • ovaries are small in proportion to body size

♀ • follicle development is evident

small testis ( J:13064 )

♂

cryptorchism ( J:13064 )

♂ • common among males

limbs/digits/tail

brachypodia ( J:13064 )

• feet are short relative to body length

long tail ( J:13064 )

• the tail is long in proportion to body length

homeostasis/metabolism

abnormal energy homeostasis ( J:13064 )

• lower than normal activity is not seen if normal siblings are removed from litters to increase milk available to mutant mice

behavior/neurological

abnormal sexual interaction ( J:13064 )

♂ • sexual activity of males with normal genitalia does not extend beyond interest in oestral females

hearing/vestibular/ear

small ears ( J:13064 )

• at 4 days of age the pinna of pygmy mice are smaller compared to normal mice

• by 12 days of age the ear size differential is pronounced

integument

long hair ( J:13064 )

• the coat appears long in proportion to body length

Genotype
MGI:3805681

hm2

• Allelic Composition: Hmga2^pg/Hmga2^pg
• Genetic Background: involves: MacArthur's small stock

growth/size/body

small ears ( J:10325 , J:25351 )

decreased body size ( J:25351 )

slow postnatal weight gain ( J:25351 )

• growth virtually ceases at 7-9 grams

proportional dwarf ( J:10325 , J:13047 , J:25351 )

• proportionally small at 10 to 14 weeks (J:10325)

• no histological evidence of pituitary involvement (J:13047)

homeostasis/metabolism

abnormal energy homeostasis ( J:25351 )

• low vitality

reproductive system

infertility ( J:13047 , J:25351 )

• Background Sensitivity: fertility in both sexes is variable depending on genetic background (J:13047)

craniofacial

small ears ( J:10325 , J:25351 )

hearing/vestibular/ear

small ears ( J:10325 , J:25351 )