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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		A
wild-type agouti
MGI:1856464
Summary 45 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		A/A Not Specified MGI:5460857
ht2
 		Ahvy/A B6.C3-Bpifa2a Ahvy MGI:4453172
ht3
 		Aiy/A C3H/HeJ-Aiy MGI:3821616
ht4
 		Aw-47J/A C57BL/6J-Aw-47J MGI:2181396
ht5
 		A/atl involves: 101/H * C3H/HeH MGI:5471527
ht6
 		Ay/A involves: C3H/HeJ * C57BL/6J-Ay/a MGI:5086113
ht7
 		Ay/A involves: C57BL/6 MGI:3773447
ht8
 		Ay-Jkn/A involves: C57BL/6N MGI:3805937
ht9
 		A/atwp Not Specified MGI:4367212
cx10
 		A/a
In(11Trp53;11Wnt3)8Brd/+ 		either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J) MGI:5766498
cx11
 		As/As
A/A 		involves: 101/H * C3H/HeH MGI:4418456
cx12
 		a/A
Pomctm1Sora/Pomctm1Sora 		involves: 129S6/SvEvTac MGI:3805940
cx13
 		a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/? 		involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805942
cx14
 		A/?
DctSlt-lt/DctSlt-lt 		involves: C3H/HeJ MGI:3027715
cx15
 		A/?
DctSlt-lt/Dct+ 		involves: C3H/HeJ MGI:3576263
cx16
 		Ay/A
Pepddal/Pepddal 		involves: C3H/HeJ * CBA/J MGI:5605663
cx17
 		Ay/A
Prkar2btm2Gsm/Prkar2btm2Gsm 		involves: C57BL/6 MGI:3773448
cx18
 		Ay/A
Prkar2btm2Gsm/Prkar2b+ 		involves: C57BL/6 MGI:3773449
cx19
 		A/?
Tyrc/Tyrem12Ove 		involves: C57BL/6 * FVB MGI:5822839
cx20
 		A/?
Tyrem1Ove/Tyrem1Ove 		involves: C57BL/6 * FVB MGI:5817495
cx21
 		A/?
Tyrc/Tyrem1Ove 		involves: C57BL/6 * FVB MGI:5817496
cx22
 		A/?
Tyrc/Tyrem6Ove 		involves: C57BL/6 * FVB MGI:5817691
cx23
 		A/?
Tyrem7Ove/Tyrem7Ove 		involves: C57BL/6 * FVB MGI:5818811
cx24
 		A/?
Tyrc/Tyrem7Ove 		involves: C57BL/6 * FVB MGI:5818819
cx25
 		A/?
Tyrem8Ove/Tyrem8Ove 		involves: C57BL/6 * FVB MGI:5818861
cx26
 		A/?
Tyrem9Ove/Tyrem9Ove 		involves: C57BL/6 * FVB MGI:5818876
cx27
 		A/?
Tyrem12Ove/Tyrem12Ove 		involves: C57BL/6 * FVB MGI:5818890
cx28
 		A/?
Tyrem13Ove/Tyrem13Ove 		involves: C57BL/6 * FVB MGI:5818900
cx29
 		A/?
Tyrc/Tyrem13Ove 		involves: C57BL/6 * FVB MGI:5818901
cx30
 		A/a
Tyrem15Ove/Tyrem15Ove 		involves: C57BL/6 * FVB MGI:5819209
cx31
 		Ay-Jkn/A
Mc1re/Mc1re
Tg(MC1R)1Jkn/0 		involves: C57BL/6Ha * C57BL/6N MGI:3805939
cx32
 		Ay-Jkn/A
Mc1re/Mc1re 		involves: C57BL/6Ha * C57BL/6N MGI:3805938
cx33
 		Avy/A
Smchd1MommeD1/Smchd1+ 		involves: C57BL/6J * FVB/NJ MGI:3607153
cx34
 		Avy/A
Smarca5MommeD4/Smarca5+ 		involves: C57BL/6J * FVB/NJ MGI:3607160
cx35
 		Avy/A
Dnmt1MommeD2/Dnmt1+ 		involves: C57BL/6J * FVB/NJ MGI:3607157
cx36
 		A/A
Dkd/Dkd 		LPT;C3-Dkd/GrsrJ MGI:3803320
cx37
 		A/A
Mc1rE-tob/Mc1r+ 		M. m. domesticus poschiavinus MGI:5629972
cx38
 		A/A
Mc1rE-tob/Mc1rE-tob 		M. m. domesticus poschiavinus MGI:3687979
cx39
 		A/A
Hps6ru/Hps6ru 		Not Specified MGI:5466746
cx40
 		A/?
Lystbg/Lystbg
Tyrp1b/Tyrp1b 		Not Specified MGI:2654822
cx41
 		A/a
Tyrp1B-lt/Tyrp1B-lt 		Not Specified MGI:3795188
cx42
 		A/A
U/U 		Not Specified MGI:3844566
cx43
 		at/A
As/As+ 		Not Specified MGI:4418457
cx44
 		A/?
Lystbg/Lystbg
Tyrp1+/? 		Not Specified MGI:4453314
cx45
 		A/A
Tyrc-ch/Tyrc-ch 		Not Specified MGI:5460836


Genotype
MGI:5460857
hm1
Allelic
Composition		 A/A
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype

pigmentation
pigmentation phenotype ( J:36414 )
N
• wild-type coat color created by hairs with a black base, yellow subterminal band, and black tip




Genotype
MGI:4453172
ht2
Allelic
Composition		 Ahvy/A
Genetic
Background		 B6.C3-Bpifa2a Ahvy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ahvy mutation (1 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:24247 )
• Background Sensitivity: amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from creamy yellow to black
darkened coat color ( J:24247 )
• this coat pigmentation is seen when yellow pigment (phaeomelanin) is minimal; the coat resembles non-agouti black
yellow coat color ( J:24247 )
• a creamy yellow coat color predominates but black striping or patches are seen on the back and/or belly
irregular coat pigmentation ( J:24247 )
• black striping or patches are frequently seen on the back and/or belly; the remainder of the coat is creamy yellow

integument
abnormal coat/hair pigmentation ( J:24247 )
• Background Sensitivity: amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from creamy yellow to black
darkened coat color ( J:24247 )
• this coat pigmentation is seen when yellow pigment (phaeomelanin) is minimal; the coat resembles non-agouti black
yellow coat color ( J:24247 )
• a creamy yellow coat color predominates but black striping or patches are seen on the back and/or belly
irregular coat pigmentation ( J:24247 )
• black striping or patches are frequently seen on the back and/or belly; the remainder of the coat is creamy yellow




Genotype
MGI:3821616
ht3
Allelic
Composition		 Aiy/A
Genetic
Background		 C3H/HeJ-Aiy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Aiy mutation (1 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:30922 )
• heterozygotes and homozygotes are indistinguishable
yellow coat color ( J:30922 )
• color ranges from very sooty yellow to indistinguishable from wild-type agouti
• ventrum is slightly lighter than dorsal pigmentation
mottled coat ( J:30922 )
• mottling is variable

growth/size/body
obese ( J:30922 )
• become obese as adults

integument
abnormal coat/hair pigmentation ( J:30922 )
• heterozygotes and homozygotes are indistinguishable
yellow coat color ( J:30922 )
• color ranges from very sooty yellow to indistinguishable from wild-type agouti
• ventrum is slightly lighter than dorsal pigmentation
mottled coat ( J:30922 )
• mottling is variable

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
 J:30922




Genotype
MGI:2181396
ht4
Allelic
Composition		 Aw-47J/A
Genetic
Background		 C57BL/6J-Aw-47J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Aw-47J mutation (0 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation

integument




Genotype
MGI:5471527
ht5
Allelic
Composition		 A/atl
Genetic
Background		 involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
atl mutation (0 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat/hair pigmentation ( J:169366 )
• pale colored belly fur

pigmentation
abnormal coat/hair pigmentation ( J:169366 )
• pale colored belly fur




Genotype
MGI:5086113
ht6
Allelic
Composition		 Ay/A
Genetic
Background		 involves: C3H/HeJ * C57BL/6J-Ay/a
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay mutation (14 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:3773447
ht7
Allelic
Composition		 Ay/A
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay mutation (14 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased brown adipose tissue amount ( J:131039 )
• female mice have a 6-fold gain in weight of BAT compared to littermate controls
increased gonadal fat pad weight ( J:131039 )
• female mice have almost a 7-fold gain in weight of fat pad
increased inguinal fat pad weight ( J:131039 )
• female mice have a greater than 6-fold gain in weight of fat pad
increased retroperitoneal fat pad weight ( J:131039 )
• female mice have almost a 6-fold gain in weight of fat pad
increased percent body fat/body weight ( J:131039 )
• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls
• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
increased food intake ( J:131039 )
• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls
decreased locomotor activity ( J:131039 )
• the locomotor activity of mice is about half that of wild-type mice

growth/size/body
obese ( J:131039 )
• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls
increased body length ( J:131039 )
• female but not male mice have a significant 5% increase in their body length
increased susceptibility to weight gain ( J:131039 )
• mice gain weight at a greater rate than littermate controls starting at six weeks of age
increased liver weight ( J:131039 )
• female mice have almost a 2-fold gain in weight of the liver

homeostasis/metabolism
increased circulating leptin level ( J:131039 )
• circulating levels of leptin are over 12-fold higher compared to littermate controls

liver/biliary system
increased liver weight ( J:131039 )
• female mice have almost a 2-fold gain in weight of the liver

pigmentation
yellow coat color ( J:131039 )
• mice have a yellow coat color

integument
yellow coat color ( J:131039 )
• mice have a yellow coat color

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
obesity DOID:9970 OMIM:601665
 J:131039




Genotype
MGI:3805937
ht8
Allelic
Composition		 Ay-Jkn/A
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay-Jkn mutation (0 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the color is paler than observed in Mc1re homozygotes

integument
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the color is paler than observed in Mc1re homozygotes




Genotype
MGI:4367212
ht9
Allelic
Composition		 A/atwp
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
atwp mutation (0 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:16568 )
• dorsum is agouti, ventrum white
• this allele is recessive on the dorsum, dominant on the ventrum
abnormal ventral coat pigmentation ( J:16568 )
• ventral coat color is white, identical to the color and pattern of a Aw/- mouse
• this allele is dominant to A on the ventrum

integument
abnormal coat/hair pigmentation ( J:16568 )
• dorsum is agouti, ventrum white
• this allele is recessive on the dorsum, dominant on the ventrum
abnormal ventral coat pigmentation ( J:16568 )
• ventral coat color is white, identical to the color and pattern of a Aw/- mouse
• this allele is dominant to A on the ventrum




Genotype
MGI:5766498
cx10
Allelic
Composition		 A/a
In(11Trp53;11Wnt3)8Brd/+
Genetic
Background		 either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (228 available); any a mutation (466 available)
A mutation (20 available); any a mutation (466 available)
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

growth/size/body
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

hearing/vestibular/ear
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

integument
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation
decreased ear pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
abnormal tail pigmentation ( J:56548 )
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.




Genotype
MGI:4418456
cx11
Allelic
Composition		 As/As
A/A
Genetic
Background		 involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
As mutation (0 available); any As mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:5027 )
• amount of yellow pigment produced by an agouti genotype is reduced and coat is darker than expected
• the normally yellow pinna hairs for all agouti alleles except ae are black (or brown on a homozygous brown background)

integument
darkened coat color ( J:5027 )
• amount of yellow pigment produced by an agouti genotype is reduced and coat is darker than expected
• the normally yellow pinna hairs for all agouti alleles except ae are black (or brown on a homozygous brown background)




Genotype
MGI:3805940
cx12
Allelic
Composition		 a/A
Pomctm1Sora/Pomctm1Sora
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (228 available); any a mutation (466 available)
A mutation (20 available); any a mutation (466 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a slightly more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a slightly more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)




Genotype
MGI:3805942
cx13
Allelic
Composition		 a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (228 available); any a mutation (466 available)
A mutation (20 available); any a mutation (466 available)
Mc1re mutation (4 available); any Mc1r mutation (44 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (22 available)
Tg(MC1R)1Jkn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

integument
yellow coat color ( J:129904 )
• mice have a much more yellow coat than agouti controls
abnormal hair follicle pheomelanosome pheomelanin content ( J:129904 )
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)




Genotype
MGI:3027715
cx14
Allelic
Composition		 A/?
DctSlt-lt/DctSlt-lt
Genetic
Background		 involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
DctSlt-lt mutation (1 available); any Dct mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:27515 )
• on an agouti background, the fur of homozygous DctSlt-lt mice appears yellowish brown.

integument
diluted coat color ( J:27515 )
• on an agouti background, the fur of homozygous DctSlt-lt mice appears yellowish brown.




Genotype
MGI:3576263
cx15
Allelic
Composition		 A/?
DctSlt-lt/Dct+
Genetic
Background		 involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
DctSlt-lt mutation (1 available); any Dct mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:27515 )
• on an agouti background, the coat color of mice heterozygous for DctSlt-lt is light agouti.

integument
diluted coat color ( J:27515 )
• on an agouti background, the coat color of mice heterozygous for DctSlt-lt is light agouti.




Genotype
MGI:5605663
cx16
Allelic
Composition		 Ay/A
Pepddal/Pepddal
Genetic
Background		 involves: C3H/HeJ * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay mutation (14 available); any a mutation (466 available)
Pepddal mutation (1 available); any Pepd mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
darkened coat color ( J:143333 )
• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

pigmentation
darkened coat color ( J:143333 )
• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

growth/size/body
obese ( J:143333 )
• mice heterozygous for yellow are obese and longer than normal to the same degree regardless of being wild-type or homozygous for dark-like




Genotype
MGI:3773448
cx17
Allelic
Composition		 Ay/A
Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay mutation (14 available); any a mutation (466 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased brown adipose tissue amount ( J:131039 )
• female mice have a 2-fold gain in mg of BAT compared to littermate controls
increased gonadal fat pad weight ( J:131039 )
• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls
increased inguinal fat pad weight ( J:131039 )
• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
increased retroperitoneal fat pad weight ( J:131039 )
• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
increased percent body fat/body weight ( J:131039 )
• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
behavior/neurological phenotype ( J:131039 )
N
• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the Ay mutant allele
increased locomotor activity ( J:131039 )
• locomotor activity is about 1.5-fold higher compared to wild-type control mice

growth/size/body
growth/size/body region phenotype ( J:131039 )
N
• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the Ay mutant allele
• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the Ay mutant allele
increased susceptibility to weight gain ( J:131039 )
• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age
• rate of weight gain in male mice is significantly less than in Ay heterozygotes

pigmentation
yellow coat color ( J:131039 )
• mice have a yellow coat color

integument
yellow coat color ( J:131039 )
• mice have a yellow coat color




Genotype
MGI:3773449
cx18
Allelic
Composition		 Ay/A
Prkar2btm2Gsm/Prkar2b+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay mutation (14 available); any a mutation (466 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased percent body fat/body weight ( J:131039 )
• mice have increased percentage of body fat but is 10% less than what is observed in Ay heterozygotes

behavior/neurological
polyphagia ( J:131039 )
• mice have a higher food consumption but is about 10% less than the amount Ay heterozygotes consume

growth/size/body
increased susceptibility to weight gain ( J:131039 )
• mice have increased rate of weight growth compared to wild-type mice but significantly less than in Ay heterozygotes




Genotype
MGI:5822839
cx19
Allelic
Composition		 A/?
Tyrc/Tyrem12Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrc mutation (80 available); any Tyr mutation (381 available)
Tyrem12Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice on an agouti background appears very light brown

pigmentation
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice on an agouti background appears very light brown




Genotype
MGI:5817495
cx20
Allelic
Composition		 A/?
Tyrem1Ove/Tyrem1Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrem1Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• mice homozygous for this endonuclease-mediated tyrosinase allele on an agouti background appear light agouti.

pigmentation
diluted coat color ( J:94077 )
• mice homozygous for this endonuclease-mediated tyrosinase allele on an agouti background appear light agouti.




Genotype
MGI:5817496
cx21
Allelic
Composition		 A/?
Tyrc/Tyrem1Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrc mutation (80 available); any Tyr mutation (381 available)
Tyrem1Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.

pigmentation
diluted coat color ( J:94077 )
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.
decreased eye pigmentation ( J:94077 )
• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.

vision/eye
decreased eye pigmentation ( J:94077 )
• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.




Genotype
MGI:5817691
cx22
Allelic
Composition		 A/?
Tyrc/Tyrem6Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrc mutation (80 available); any Tyr mutation (381 available)
Tyrem6Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.

pigmentation
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.
variegated eye pigmentation pattern ( J:94077 )
• eyes are dark with mosaic pigmentation

vision/eye
variegated eye pigmentation pattern ( J:94077 )
• eyes are dark with mosaic pigmentation




Genotype
MGI:5818811
cx23
Allelic
Composition		 A/?
Tyrem7Ove/Tyrem7Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrem7Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of these mice exhibits nearly normal agouti coloration

pigmentation
diluted coat color ( J:94077 )
• the fur of these mice exhibits nearly normal agouti coloration
abnormal eye pigmentation ( J:94077 )
• mice homozygous for this Tyr promoter mutation exhibit nearly normal ocular pigmentation

vision/eye
abnormal eye pigmentation ( J:94077 )
• mice homozygous for this Tyr promoter mutation exhibit nearly normal ocular pigmentation




Genotype
MGI:5818819
cx24
Allelic
Composition		 A/?
Tyrc/Tyrem7Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrc mutation (80 available); any Tyr mutation (381 available)
Tyrem7Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of these compound Tyr mutant mice appears light agouti

pigmentation
diluted coat color ( J:94077 )
• the fur of these compound Tyr mutant mice appears light agouti




Genotype
MGI:5818861
cx25
Allelic
Composition		 A/?
Tyrem8Ove/Tyrem8Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrem8Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray
diluted coat color ( J:94077 )
• the fur of these mice appears light tan
decreased tail pigmentation ( J:94077 )
• tails of these mice exhibit minimal pigmentation

craniofacial
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray

limbs/digits/tail
decreased tail pigmentation ( J:94077 )
• tails of these mice exhibit minimal pigmentation

growth/size/body
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray

hearing/vestibular/ear
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray

pigmentation
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray
diluted coat color ( J:94077 )
• the fur of these mice appears light tan
decreased tail pigmentation ( J:94077 )
• tails of these mice exhibit minimal pigmentation

vision/eye




Genotype
MGI:5818876
cx26
Allelic
Composition		 A/?
Tyrem9Ove/Tyrem9Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrem9Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of mice homozygous for this Tyr promoter mutation on an agouti background have nearly normal agouti pigmentation

pigmentation
diluted coat color ( J:94077 )
• the fur of mice homozygous for this Tyr promoter mutation on an agouti background have nearly normal agouti pigmentation
decreased eye pigmentation ( J:94077 )
• homozygous mutant mice have nearly normal ocular pigmentation

vision/eye
decreased eye pigmentation ( J:94077 )
• homozygous mutant mice have nearly normal ocular pigmentation




Genotype
MGI:5818890
cx27
Allelic
Composition		 A/?
Tyrem12Ove/Tyrem12Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrem12Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of mice homozygous for this Tyr mutation on an agouti background appears light brown

pigmentation
diluted coat color ( J:94077 )
• the fur of mice homozygous for this Tyr mutation on an agouti background appears light brown
decreased eye pigmentation ( J:94077 )
• the ocular pigmentation of these mice appears altered compared to that of wild-type mice

vision/eye
decreased eye pigmentation ( J:94077 )
• the ocular pigmentation of these mice appears altered compared to that of wild-type mice




Genotype
MGI:5818900
cx28
Allelic
Composition		 A/?
Tyrem13Ove/Tyrem13Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrem13Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:94077 )
N
• normal agouti pigmentatioon




Genotype
MGI:5818901
cx29
Allelic
Composition		 A/?
Tyrc/Tyrem13Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrc mutation (80 available); any Tyr mutation (381 available)
Tyrem13Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:94077 )
N
• normal agouti pigmentation




Genotype
MGI:5819209
cx30
Allelic
Composition		 A/a
Tyrem15Ove/Tyrem15Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (228 available); any a mutation (466 available)
A mutation (20 available); any a mutation (466 available)
Tyrem15Ove mutation (1 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
decreased tail pigmentation ( J:94077 )
• the tails of these mice exhibit slightly lighter pigmentation than tails of wild-type agouti mice

integument
diluted coat color ( J:94077 )
• these mice exhibit nearly normal agouti pigmentation
decreased tail pigmentation ( J:94077 )
• the tails of these mice exhibit slightly lighter pigmentation than tails of wild-type agouti mice

pigmentation
diluted coat color ( J:94077 )
• these mice exhibit nearly normal agouti pigmentation
decreased tail pigmentation ( J:94077 )
• the tails of these mice exhibit slightly lighter pigmentation than tails of wild-type agouti mice




Genotype
MGI:3805939
cx31
Allelic
Composition		 Ay-Jkn/A
Mc1re/Mc1re
Tg(MC1R)1Jkn/0
Genetic
Background		 involves: C57BL/6Ha * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay-Jkn mutation (0 available); any a mutation (466 available)
Mc1re mutation (4 available); any Mc1r mutation (44 available)
Tg(MC1R)1Jkn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jkn heterozygotes

integument
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jkn heterozygotes




Genotype
MGI:3805938
cx32
Allelic
Composition		 Ay-Jkn/A
Mc1re/Mc1re
Genetic
Background		 involves: C57BL/6Ha * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Ay-Jkn mutation (0 available); any a mutation (466 available)
Mc1re mutation (4 available); any Mc1r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jknheterozygotes

integument
yellow coat color ( J:129904 )
• mice have a pale yellow coat color
• the yellow color is darker than what is observed in Ay-Jknheterozygotes




Genotype
MGI:3607153
cx33
Allelic
Composition		 Avy/A
Smchd1MommeD1/Smchd1+
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Avy mutation (4 available); any a mutation (466 available)
Smchd1MommeD1 mutation (0 available); any Smchd1 mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:99816 )
• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

integument
yellow coat color ( J:99816 )
• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made




Genotype
MGI:3607160
cx34
Allelic
Composition		 Avy/A
Smarca5MommeD4/Smarca5+
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Avy mutation (4 available); any a mutation (466 available)
Smarca5MommeD4 mutation (1 available); any Smarca5 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
mottled coat ( J:99816 )
• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled

integument
mottled coat ( J:99816 )
• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled




Genotype
MGI:3607157
cx35
Allelic
Composition		 Avy/A
Dnmt1MommeD2/Dnmt1+
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Avy mutation (4 available); any a mutation (466 available)
Dnmt1MommeD2 mutation (0 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:99816 )
• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

integument
yellow coat color ( J:99816 )
• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made




Genotype
MGI:3803320
cx36
Allelic
Composition		 A/A
Dkd/Dkd
Genetic
Background		 LPT;C3-Dkd/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Dkd mutation (1 available); any Dkd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Phenotype of Dkd/Dkd mouse

pigmentation
abnormal dorsoventral coat patterning ( J:137334 )
• a darkened dorsal stripe if seen when the first coat comes in

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:137334 )
N
• ABR assessment at 4 weeks of age is normal

vision/eye
vision/eye phenotype ( J:137334 )
N
• eyes are normal by ophthalmoscopic examination at 4 weeks of age

integument
abnormal dorsoventral coat patterning ( J:137334 )
• a darkened dorsal stripe if seen when the first coat comes in




Genotype
MGI:5629972
cx37
Allelic
Composition		 A/A
Mc1rE-tob/Mc1r+
Genetic
Background		 M. m. domesticus poschiavinus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Mc1rE-tob mutation (4 available); any Mc1r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat/hair pigmentation ( J:22593 )
• Mc1rE-tob influences the expression of agouti
darkened coat color ( J:22593 )
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when some agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re A/a mice have a darkened back

pigmentation
abnormal coat/hair pigmentation ( J:22593 )
• Mc1rE-tob influences the expression of agouti
darkened coat color ( J:22593 )
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when some agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re A/a mice have a darkened back




Genotype
MGI:3687979
cx38
Allelic
Composition		 A/A
Mc1rE-tob/Mc1rE-tob
Genetic
Background		 M. m. domesticus poschiavinus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Mc1rE-tob mutation (4 available); any Mc1r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:22593 )
• Mc1rE-tob influences the expression of agouti
darkened coat color ( J:22593 )
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re mice that are also homozygous non-agouti are black because Mc1rE-tob only affects the expression of agouti

integument
abnormal coat/hair pigmentation ( J:22593 )
• Mc1rE-tob influences the expression of agouti
darkened coat color ( J:22593 )
• the color is difficult to distinguish from non-agouti black before 8 weeks of age when agouti hairs appear on the flanks; the back remains darkened
• Mc1rE-tob/Mc1re mice that are also homozygous non-agouti are black because Mc1rE-tob only affects the expression of agouti




Genotype
MGI:5466746
cx39
Allelic
Composition		 A/A
Hps6ru/Hps6ru
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Hps6ru mutation (3 available); any Hps6 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:13122 )
• the black pigment in the coat is reduced on this background to dark slate color but the yellow pigmented agouti band at the hair tips is barely reduced in intensity so mice of this genotype are a slightly lighter agouti

pigmentation
diluted coat color ( J:13122 )
• the black pigment in the coat is reduced on this background to dark slate color but the yellow pigmented agouti band at the hair tips is barely reduced in intensity so mice of this genotype are a slightly lighter agouti




Genotype
MGI:2654822
cx40
Allelic
Composition		 A/?
Lystbg/Lystbg
Tyrp1b/Tyrp1b
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Lystbg mutation (6 available); any Lyst mutation (227 available)
Tyrp1b mutation (29 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:29744 )
• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color
• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice
decreased eye pigmentation ( J:29744 )
• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

vision/eye
decreased eye pigmentation ( J:29744 )
• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

integument
diluted coat color ( J:29744 )
• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color
• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice




Genotype
MGI:3795188
cx41
Allelic
Composition		 A/a
Tyrp1B-lt/Tyrp1B-lt
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (228 available); any a mutation (466 available)
A mutation (20 available); any a mutation (466 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (162 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:13094 )
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft

integument
diluted coat color ( J:13094 )
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft




Genotype
MGI:3844566
cx42
Allelic
Composition		 A/A
U/U
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
U mutation (2 available); any U mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:280 , J:78801 )
• U modifies agouti dominance: when U is homozygous there is a marked darkening in A/A mice; when U is heterozygotes the darkening is somewhat less (J:280)
• the coat is darkened relative to the number of copies of U and a as follows: A/a; U/U > A/a; U/u = A/A; U/U > A/A; U/u = A/a; u/u > A/A; u/u (J:78801)

integument
darkened coat color ( J:280 , J:78801 )
• U modifies agouti dominance: when U is homozygous there is a marked darkening in A/A mice; when U is heterozygotes the darkening is somewhat less (J:280)
• the coat is darkened relative to the number of copies of U and a as follows: A/a; U/U > A/a; U/u = A/A; U/U > A/A; U/u = A/a; u/u > A/A; u/u (J:78801)




Genotype
MGI:4418457
cx43
Allelic
Composition		 at/A
As/As+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
As mutation (0 available); any As mutation (0 available)
at mutation (9 available); any a mutation (466 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:5027 )
• only the agouti allele on the same chromosome as the As allele is affected
• the expected cream belly is not seen for this genotype; the mouse looks normal agouti

integument
abnormal coat/hair pigmentation ( J:5027 )
• only the agouti allele on the same chromosome as the As allele is affected
• the expected cream belly is not seen for this genotype; the mouse looks normal agouti




Genotype
MGI:4453314
cx44
Allelic
Composition		 A/?
Lystbg/Lystbg
Tyrp1+/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Lystbg mutation (6 available); any Lyst mutation (227 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
decreased ear pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
diluted coat color ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
irregular coat pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
decreased tail pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls
abnormal eye pigmentation ( J:29744 )
• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

vision/eye
abnormal eye pigmentation ( J:29744 )
• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

limbs/digits/tail
decreased tail pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

craniofacial
decreased ear pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

hearing/vestibular/ear
decreased ear pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

integument
decreased ear pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls
diluted coat color ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
irregular coat pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base
• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice
decreased tail pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

growth/size/body
decreased ear pigmentation ( J:29744 )
• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls




Genotype
MGI:5460836
cx45
Allelic
Composition		 A/A
Tyrc-ch/Tyrc-ch
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (20 available); any a mutation (466 available)
Tyrc-ch mutation (79 available); any Tyr mutation (381 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat appearance ( J:36414 )
• the contrasted effects of this genotype on eumelanin and phaeomelanin produces a grizzled color pattern or chinchilla effect
abnormal coat/hair pigmentation ( J:36414 )
• reduced melanin content alters the wild-type agouti color to gray
abnormal hair follicle pheomelanosome pheomelanin content ( J:36414 )
• in this genotype yellow pigment in the hair shaft is reduced or absent

pigmentation
abnormal coat/hair pigmentation ( J:36414 )
• reduced melanin content alters the wild-type agouti color to gray
abnormal hair follicle pheomelanosome pheomelanin content ( J:36414 )
• in this genotype yellow pigment in the hair shaft is reduced or absent




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory