integument
• mice have white "macular" or spots
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pigmentation
• mice have white "macular" or spots
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Allele Symbol Allele Name Allele ID |
Atp7aMo-ml mottled macular MGI:1856466 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice have white "macular" or spots
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• mice have white "macular" or spots
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• copper content in the cerebrum is decreased
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• copper content in the small intestine and kidney is increased
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• mice exhibit curly/straight whiskers
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• macular fur color
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• copper content in the cerebrum is decreased
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• macular fur color
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 90% die by 15 days of age, none survive to weaning
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• the coat is white and contrasts strikingly with (normal) black eyes
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• the coat is white and contrasts strikingly with (normal) black eyes
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• noticeable by 3 days of age
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• after 10 days of age
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• after 10 days of age
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• growth rate, as measured by weight, is reduced compared with normal littermates
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• males exhibit decreased body weight at 10 and 14 days of age but not at 10 days indicating decreased postnatal growth
• treatment with copper does not affect body weight
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• white fur
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N |
• urate oxidase activity in the liver is normal
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• copper content in the small and large intestine is increased
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• copper content in the heart is decreased
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• copper content in the cerebrum, cerebellum and brain stem is decreased
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• liver copper content is decreased in 7 to 14 day old males
(J:1132)
• treatment with copper increases liver copper content
(J:1132)
(J:12745)
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• cytochrome c oxidase activity in the brain (cerebrum, cerebellum, brain stem) and heart is decreased
• however, cytochrome c oxidase activity in the lung, spleen, thymus, intestine, kidney and liver is not affected
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• large intestine weight is lower in 10 day old mice
• copper treatment increases large intestine weight
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• spleen weight is lower in 10 day old mice
• copper treatment increases spleen weight
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• liver copper content is decreased in 7 to 14 day old males
(J:1132)
• treatment with copper increases liver copper content
(J:1132)
(J:12745)
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• spleen weight is lower in 10 day old mice
• copper treatment increases spleen weight
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• white fur
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• copper content in the cerebrum, cerebellum and brain stem is decreased
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Menkes disease | DOID:1838 |
OMIM:309400 |
J:1132 , J:12745 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Background Sensitivity: a mixed background can extend the life span of some mice but still none are successfully weaned
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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