Phenotypes associated with this allele

• Allele Symbol: Hephl1^cw
• Allele Name: curly whiskers
• Allele ID: MGI:1856476
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hephl1^cw/Hephl1^cw	CWD/LeJ	MGI:3590075
hm2	Hephl1^cw/Hephl1^cw	involves: CBA/Cbi	MGI:3590067
ht3	Hephl1^cw/Hephl1^+	involves: CBA/Cbi	MGI:3590068
ht4	Hephl1^cw/Hephl1^cw-2J	(CWD/LeJ x B10.SM-H2^v H2-T18^b/(70NS)SnJ)F1	MGI:6315329

Genotype
MGI:3590075

hm1

• Allelic Composition: Hephl1^cw/Hephl1^cw
• Genetic Background: CWD/LeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Curly whiskers in Hephl1^cw/Hephl1^cw mice

mortality/aging

premature death ( J:24875 )

• mean survival time is 500 days

neoplasm

increased lymphoma incidence ( J:24875 )

increased B cell derived lymphoma incidence ( J:24875 )

• this mutation is an experimental model for B-cell lymphoma

• 85% of mice develop lymphoma

• histology indicates follicular germinal center-cell lymphoma

• immunofluoresence assays demonstrate absence of thymus cell antigens

• immunofluoresence assays reveal 100% of cells are positive for surface immuoglobulin

• a leukemic blood profile is not usually associated with this lymphoma

hematopoietic system

enlarged thymus ( J:24875 )

• less than 20% of mice develop enlarged lymphoma

abnormal spleen morphology ( J:24875 )

enlarged spleen ( J:24875 )

immune system

abnormal immune system morphology ( J:24875 )

enlarged thymus ( J:24875 )

• less than 20% of mice develop enlarged lymphoma

abnormal spleen morphology ( J:24875 )

enlarged spleen ( J:24875 )

abnormal lymph node morphology ( J:24875 )

integument

curly vibrissae ( J:24875 , J:276072 )

• easliy observed soon after birth (J:24875)

endocrine/exocrine glands

enlarged thymus ( J:24875 )

• less than 20% of mice develop enlarged lymphoma

growth/size/body

enlarged spleen ( J:24875 )

Genotype
MGI:3590067

hm2

• Allelic Composition: Hephl1^cw/Hephl1^cw
• Genetic Background: involves: CBA/Cbi

pigmentation

darkened coat color ( J:5006 )

• described for a CBA background

integument

abnormal coat/ hair morphology ( J:5006 )

darkened coat color ( J:5006 )

• described for a CBA background

abnormal hair texture ( J:5006 )

• coat hair types are not waved

abnormal vibrissa morphology ( J:5006 )

curly vibrissae ( J:5006 )

• curled vibrissae are obvious soon after birth

Genotype
MGI:3590068

ht3

• Allelic Composition: Hephl1^cw/Hephl1⁺
• Genetic Background: involves: CBA/Cbi

integument

abnormal vibrissa morphology ( J:5006 )

curly vibrissae ( J:5006 )

• slightly curled vibrissae are not reliably observed

Genotype
MGI:6315329

ht4

• Allelic Composition: Hephl1^cw/Hephl1^cw-2J
• Genetic Background: (CWD/LeJ x B10.SM-H2^v H2-T18^b/(70NS)SnJ)F1

integument

curly vibrissae ( J:276072 )

• compound heterozygotes have curly vibrissae similar to the phenotype of the individual homozygotes