Phenotypes associated with this allele

• Allele Symbol: Qki^qk-l1
• Allele Name: quaking lethal 1
• Allele ID: MGI:1856538
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qki^qk-l1/Qki^qk-l1	involves: BTBR	MGI:3790089

Genotype
MGI:3790089

hm1

• Allelic Composition: Qki^qk-l1/Qki^qk-l1
• Genetic Background: involves: BTBR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation and impaired vascular development in Qki^qk-l1/Qki^qk-l1 and Qki^qk-k2/Qki^qk-k2 embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:106770 )

• homozygotes die at midgestation due to lack of vascular remodeling

embryo

abnormal vitelline vasculature morphology ( J:106770 )

• at E10.5, large vitelline vessels have not formed and capillary plexus is dilated and unremodeled

embryonic growth retardation ( J:106770 )

• at E10.5, embryos are growth-retarded

abnormal anterior visceral endoderm morphology ( J:106770 )

growth/size/body

embryonic growth retardation ( J:106770 )

• at E10.5, embryos are growth-retarded

cardiovascular system

abnormal angiogenesis ( J:106770 )

• at E10.5, embryos lack mature vasculature formation in the head and between somites

• vessel structures are disorganized and do not form a remodeled capillary network

abnormal vitelline vasculature morphology ( J:106770 )

• at E10.5, large vitelline vessels have not formed and capillary plexus is dilated and unremodeled

abnormal heart development ( J:106770 )

abnormal heart looping ( J:106770 )

• hearts are less tightly looped than wild-type at E10.5

pericardial effusion ( J:106770 )

• seen at E10.5

limbs/digits/tail

abnormal tail development ( J:106770 )

• tail formation and growth is blunted, observed at E10.5

homeostasis/metabolism

pericardial effusion ( J:106770 )

• seen at E10.5