All Phenotypes Qki<qk-v> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Qki^qk-v
quaking viable
MGI:1856539

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qki^qk-v/Qki^qk-v	B6C3Fe a/a-Qki^qk-v/J	MGI:3698852
hm2	Qki^qk-v/Qki^qk-v	involves: C3H/Di * DBA/2J	MGI:3758073
hm3	Qki^qk-v/Qki^qk-v	involves: DBA/2	MGI:6459893
hm4	Qki^qk-v/Qki^qk-v	involves: DBA/2J	MGI:2674329
cx5	Qki^qk-v/Qki^qk-v Tg(PGK2-Pacrg)#Jus/?	involves: BTBR * C57BL/6J * DBA/2	MGI:5286587
cx6	Del(17)T^Orl/+ Qki^qk-v/Qki⁺	involves: C57BL/6J * Orl:Swiss	MGI:3798959

Allelic Composition	Qki^qk-v/Qki^qk-v
Genetic Background	B6C3Fe a/a-Qki^qk-v/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qki^qk-v mutation (2 available); any Qki mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Brain morphology in Qki^e5/Qki^e5 and Qki^qk-v/Qki^qk-v mice

hearing/vestibular/ear

reduced linear vestibular evoked potential ( J:116914 )

• prolonged latency for all peaks and larger amplitudes for P1/N1

nervous system

seizures ( J:102038 )

• onset of seizures begins at 6-8 weeks of age; seizures occur less frequently than in homozygous Qk^e5 mice

Purkinje cell degeneration ( J:102038 )

• aging mutants exhibit Purkinje cell axonal swellings, indicating neurodegeneration

abnormal myelination ( J:102038 , J:160743 )

• decrease in myelination, however more axons are surrounded by thin myelin sheaths than seen in Qk^e5 homozygotes (J:102038)

• microsomes prepared from brains of 18 day old homozygotes show a reduction in fatty acid chain elongation activity with arachidoyl CoA, behenoyl CoA, and palmitoyl CoA substrates (J:160743)

behavior/neurological

seizures ( J:102038 )

• onset of seizures begins at 6-8 weeks of age; seizures occur less frequently than in homozygous Qk^e5 mice

reproductive system

abnormal spermatogenesis ( J:88151 )

• the testis contain many spermatogenic cells, but few spermatozoa and the spermatozoa collected from the cauda epididymis all have abnormal heads and/or tails and less than 0.5% are barely motile, and although in vitro fertilization is not successful, intracytoplasmic sperm injection and round spermatid injection are successful in production of offspring from homozygous males

abnormal sperm flagellum morphology ( J:88151 )

necrospermia ( J:88151 )

oligozoospermia ( J:88151 )

abnormal sperm head morphology ( J:88151 )

abnormal spermiogenesis ( J:88151 )

cellular

abnormal sperm flagellum morphology ( J:88151 )

necrospermia ( J:88151 )

oligozoospermia ( J:88151 )

abnormal sperm head morphology ( J:88151 )

Allelic Composition	Qki^qk-v/Qki^qk-v
Genetic Background	involves: C3H/Di * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qki^qk-v mutation (2 available); any Qki mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

tonic seizures ( J:13141 )

• following swimming, some mice become motionless and then display a tonic extension of hindlimbs for several minutes

• some mice exhibit adduction of limbs under a flexed trunk and then become stiff and motionless for several seconds

abnormal myelination ( J:13141 )

• region from olfactory bulb to sacral spinal cord is deficient in myelin at all ages studied (12 days to 4 months)

• loss of myelination begins at the junction of peripheral and central nervous systems

• cranial and spinal nerves (except optic nerve) are myelinated

• some fragments of myelin are seen in almost all fiber tracts

• cells in white matter and grey matter tracts appear normal

behavior/neurological

tremors ( J:13141 )

• tremors are most evident in the caudal part of the trunk and proximal portions of hind extremities

• visually, the rate of tremors are 2 to 3 per second

• tremors are first observed at 10-12 days of age and reach full expression by 3 weeks

• in some animals, tremors diminish at 3 months

• physical contact with the mouse reduces or stops tremors

paraparesis ( J:13141 )

• some animals exhibit hindlimb weakness at 3 months of age

tonic seizures ( J:13141 )

• following swimming, some mice become motionless and then display a tonic extension of hindlimbs for several minutes

• some mice exhibit adduction of limbs under a flexed trunk and then become stiff and motionless for several seconds

reproductive system

reduced male fertility ( J:13141 )

• male homozygotes rarely sire offspring

Allelic Composition	Qki^qk-v/Qki^qk-v
Genetic Background	involves: DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qki^qk-v mutation (2 available); any Qki mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermiogenesis ( J:90667 )

• impaired

male infertility ( J:90667 )

Allelic Composition	Qki^qk-v/Qki^qk-v
Genetic Background	involves: DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qki^qk-v mutation (2 available); any Qki mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal response to novel object ( J:133042 )

• decrease in the frequency of exploratory sniffing (at wire mesh or a novel object) and leans against the novel object in males

increased grooming behavior ( J:133042 )

• increase in the frequency of hair fluffing in males

abnormal stationary movement ( J:133042 )

• decrease in the frequency of leaning against the wall or a novel object and single forepaw lifts in males

abnormal locomotor behavior ( J:133042 )

• decrease in the frequency of wire mesh climbing in males

abnormal gait ( J:133042 )

• walk slowly with a trembling gait

decreased locomotor activity ( J:133042 )

Allelic Composition	Qki^qk-v/Qki^qk-v Tg(PGK2-Pacrg)#Jus/?
Genetic Background	involves: BTBR * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qki^qk-v mutation (2 available); any Qki mutation (28 available)
Tg(PGK2-Pacrg)#Jus mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:90667 )

N	• all males are fertile and sire a normal number of litters • average litter size is similar to wild type controls

oligozoospermia ( J:90667 )

• sperm titers are reduced about 30% relative to wild type controls but are considerably higher than in the absence of the transgene

cellular

oligozoospermia ( J:90667 )

• sperm titers are reduced about 30% relative to wild type controls but are considerably higher than in the absence of the transgene

Allelic Composition	Del(17)T^Orl/+ Qki^qk-v/Qki⁺
Genetic Background	involves: C57BL/6J * Orl:Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17)T^Orl mutation (1 available); any Del(17)T^Orl mutation (1 available)
Qki^qk-v mutation (2 available); any Qki mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:15078 )

abnormal involuntary movement ( J:15078 )

tremors ( J:15078 )

• mice heterozygous for T and Qk display tremors characteristic of the recessive mutation QK, demonstrating that T comprises a deletion

limbs/digits/tail

abnormal tail morphology ( J:15078 )

short tail ( J:15078 )

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