Analysis Tools
mortality/aging
|
• high frequency of still-born young
|
|
• a substantial number die within 48 hours
• most die before weaning
|
limbs/digits/tail
short tail
(
J:83862
)
growth/size/body
|
• mice that survive to weaning weigh 8 grams compared with the 15-20 gram weight of controls
|
reproductive system
 |
• only 3 % to 23% of seminiferous tubules in mutant mice contain spermatozoa compared with 51-62% in normal males
|
|
|
• even when present in normal numbers spermatids frequently failed to differentiate contributing to loss of fertility
|
|
• matings of homozygous mice produce half the number of expected young
|
immune system
|
• histological analyses show disintegration of lymphocytes in both female and male neonates however the thymus of mice 1 to 4 months of age are normal
|
|
• after 6 months of age the cortex region is smaller and totally absent in some mice
|
|
• after 6 months of age the incidence of mast cells in the spleen increases
and the population becomes larger than seen on control mice
|
|
• noticeable in histological analyses after 2 months of age
|
|
• seen after 2 months of age along with a decline in activation
|
hematopoietic system
|
• histological analyses show disintegration of lymphocytes in both female and male neonates however the thymus of mice 1 to 4 months of age are normal
|
|
• after 6 months of age the cortex region is smaller and totally absent in some mice
|
|
• seen in the spleen after 2 months of age
|
|
• after 6 months of age the incidence of mast cells in the spleen increases
and the population becomes larger than seen on control mice
|
|
• noticeable in histological analyses after 2 months of age
|
|
• seen after 2 months of age along with a decline in activation
|
endocrine/exocrine glands
|
• histological analyses show disintegration of lymphocytes in both female and male neonates however the thymus of mice 1 to 4 months of age are normal
|
|
• after 6 months of age the cortex region is smaller and totally absent in some mice
|
