All Phenotypes t<w5> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	t^w5/t^wPas1	involves: M. m. brevirostris	MGI:4820966
cx2	t^w5/t^w5 Vps52^t-w5/Vps52^t-w5	B6.Cg-t^w5	MGI:5464109
cx3	Vps52^tm1.2Kab/t^w5 Vps52^t-w5	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA	MGI:5464110
cx4	T^c/T^c t^w5/t^w5	mixed	MGI:3619237

Allelic Composition	t^w5/t^wPas1
Genetic Background	involves: M. m. brevirostris

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
t^wPas1 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:6461 )

Allelic Composition	t^w5/t^w5 Vps52^t-w5/Vps52^t-w5
Genetic Background	B6.Cg-t^w5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
Vps52^t-w5 mutation (0 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal ectoderm development ( J:190873 )

• the epithelial layer of the embryonic ectoderm fails to form by E6.5

• cell proliferation is very low in the embryonic ectoderm

• however, formation of extraembryonic tissues is similar to controls

decreased embryo size ( J:190873 )

• at E6.5

abnormal blastocyst morphology ( J:190873 )

• absence of cavitation in embryonic tissues; however, cavitation is seen in extraembryonic tissues

growth/size/body

decreased embryo size ( J:190873 )

• at E6.5

Allelic Composition	Vps52^tm1.2Kab/t^w5 Vps52^t-w5
Genetic Background	involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w5 mutation (3 available); any t mutation (19 available)
Vps52^tm1.2Kab mutation (1 available); any Vps52 mutation (42 available)
Vps52^t-w5 mutation (0 available); any Vps52 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal ectoderm development ( J:190873 )

• at E6.5 all embryos show embryonic ectoderm defects typical of mice homozygous for t^w5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:106412 )

• all embryos survive past birth, but most die within two weeks

embryo

meningocele ( J:106412 )

• embryos have lumbosacral spina bifida with meningocele

abnormal roof plate morphology ( J:106412 )

• roof plate is attenuated and necrotic starting at E13.5; at E17.5 it is ruptured so that the central canal is continuous with the CSF space; blood vessels adjacent to the neural tube rupture resulting in hemorrhage into the CSF space

abnormal notochord morphology ( J:106412 )

• notochord is flattened out against the neural tube as it approaches the hind limb level

split notochord ( J:106412 )

• ome embryos show duplication or intermittent absence of the notochord

nervous system

meningocele ( J:106412 )

• embryos have lumbosacral spina bifida with meningocele

abnormal roof plate morphology ( J:106412 )

abnormal spinal cord morphology ( J:106412 )

• from E13.5, an externally visible dorsal blister which is cystic and fluid-containing is present in the lumbosacral area of the embryo

• as development continues and accessory neural tube disappear including the posterior one which merges with the spinal cord, the spinal cord is disfigured and the original spinal canal is shifted dorsally

• at the posterior end, the spinal cord spreads out and is intermingled with connective tissue, muscle fibers and immature neural tissue

behavior/neurological

hindlimb paralysis ( J:106412 )

• at birth, almost all pups display various degrees of hindlimb paralysis

skeleton

abnormal vertebral body morphology ( J:106412 )

• at E13. precartilaginous vertebral bodies just anterior to the level where accessory cords start forming have a midline furrow such that posteriorly the vertebral body is divided bilaterally

• in later embryos, bilateral ossification centers are observed anterior to the level where the vertebral body defects appear; posteriorly there is no trace of vertebral body formation

abnormal vertebral body development ( J:106412 )

• at the level of accessory cord formation, neural arch development is disturbed, causing midline defects

renal/urinary system

distended urinary bladder ( J:106412 )

• pups frequently show distended bladders at birth

digestive/alimentary system

abnormal colon morphology ( J:106412 )

• at autopsy, all mice are found to have a ruptured or very distended colon

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