All Phenotypes t<w73> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

t^w73
t, wild 73
MGI:1856571

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	t^w73/t^w73	involves: M. m. musculus	MGI:5288479
ht2	t^w73/t^wPas1	involves: M. m. brevirostris * M. m. musculus	MGI:4820970
cx3	t^w73 +/t⁺ Del(17D17Jcs40-D17Mit198)7Jcs	involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J	MGI:5428468
cx4	T/t^w73	involves: M. m. musculus	MGI:5288480

Allelic Composition	t^w73/t^w73
Genetic Background	involves: M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w73 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:14869 )

embryonic lethality between implantation and placentation, complete penetrance ( J:175675 )

• embryos develop only to the two-layered egg cylinder stage, dying within 5 days after implantation

embryo

decreased embryonic epiblast cell proliferation ( J:175675 )

• post-implantation growth of the embryo is markedly reduced

abnormal trophectoderm morphology ( J:175675 )

• the expected association of trophectoderm with the uterine decidua fails to form

• an abnormal trophectoderm does not inhibit embryonic growth to the two-layered egg cylinder stage

• growth abnormalities seen in the embryo can be attributed to a defective trophectoderm

abnormal ectoplacental cone morphology ( J:175675 )

• the expected association of ectoplacental cone with the uterine decidua does not occur

cellular

decreased embryonic epiblast cell proliferation ( J:175675 )

• post-implantation growth of the embryo is markedly reduced

Allelic Composition	t^w73/t^wPas1
Genetic Background	involves: M. m. brevirostris * M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
t^w73 mutation (0 available); any t mutation (19 available)
t^wPas1 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:6461 )

Allelic Composition	t^w73 +/t⁺ Del(17D17Jcs40-D17Mit198)7Jcs
Genetic Background	involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(17D17Jcs40-D17Mit198)7Jcs mutation (0 available); any Del(17D17Jcs40-D17Mit198)7Jcs mutation (0 available)
t^w73 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:99488 )

• the deletion in this genotype identifies a locus on haplotype t^w73 that causes lethality at birth, t^w73lab

Allelic Composition	T/t^w73
Genetic Background	involves: M. m. musculus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
T mutation (22 available); any T mutation (59 available)
t^w73 mutation (0 available); any t mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

transmission ratio distortion ( J:175677 )

• males of this genotype transmit t^w73 to 88.6 per cent of offspring

limbs/digits/tail

absent tail ( J:175677 )

• all mice of this genotype are tailless

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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