Analysis Tools|
Allele Symbol Allele Name Allele ID |
Aft abnormal feet and tail MGI:1856589 |
| Summary |
2 genotypes |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• syndactyly of digits 3 and 4 of the hindfeet, 50% penetrance
|
|
• 50% penetrance
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotypes of Aft mutation
|
• partial syndactyly of digits 3 and 4 on the hindlimbs, commonly unilateral
• several mutants are seen in which digits other than 3 and 4 are fused
|
|
• syndactyly is caused by the persistence of the skin web between the digits and not due to fused bony elements
|
|
• tail kinks are most likely caused by varying degrees of cartilage overgrowth and fusion and a dysmorphogenesis of bony elements attached to the fusion site
|
|
• incompletely penetrant progressive late-onset hair loss (around 6-8 months of age) that starts locally around the snout and back of ears
|
|
• at around 6-8 months of age, when local hair loss begins, the fur appears clumpy and unkempt
|
|
• skin shows focal areas of decreased hair follicle density with fibrous tracts, pigment incontinence and increased mast cells
|
|
• late-onset (6-8 months of age) of skin lesions following hair loss that progress into bleeding ulcerations
|
|
• fibrosis in the dermis
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
