reproductive system
• mature spermatids are misshapen appearing short and wide rather than elongated with abnormal nuclei
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• the majority of males are completely sterile
• backcrossing for 2 generations onto a FVB/N or SJL/J background increased the penetrance of this phenotype to 100%
• males resulting from backcrossing for 2 to 3 generations onto a C57BL/6 or BALB/cByJ background are fertile
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cellular
• mature spermatids are misshapen appearing short and wide rather than elongated with abnormal nuclei
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